Email this article STIM1 Protein Activates Store-Operated Calcium Channels in Cellular Model of Huntington’s Disease
- Authors: Vigont V.A.1, Zimina O.A.1, Glushankova L.N.1, Kolobkova J.A.1, Ryazantseva M.A.1, Mozhayeva G.N.1, Kaznacheyeva E.V.1
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Affiliations:
- Institute of Cytology, Russian Academy of Sciences
- Issue: Vol 6, No 4 (2014)
- Pages: 40-47
- Section: Research Articles
- Submitted: 17.01.2020
- Published: 15.12.2014
- URL: https://actanaturae.ru/2075-8251/article/view/10523
- DOI: https://doi.org/10.32607/20758251-2014-6-4-40-47
- ID: 10523
Cite item
Abstract
We have shown that the expression of full-length mutated huntingtin in human neuroblastoma cells (SK-N-SH) leads to an abnormal increase in calcium entry through store-operated channels. In this paper, the expression of the N-terminal fragment of mutated huntingtin (Htt138Q-1exon) is shown to be enough to provide an actual model for Huntington’s disease. We have shown that Htt138Q-1exon expression causes increased store-operated calcium entry, which is mediated by at least two types of channels in SK-N-SH cells with different reversal potentials. Calcium sensor, STIM1, is required for activation of store-operated calcium entry in these cells. The results provide grounds for considering the proteins responsible for the activation and maintenance of the store-operated calcium entry as promising targets for developing novel therapeutics for neurodegenerative diseases.
Keywords
About the authors
V. A. Vigont
Institute of Cytology, Russian Academy of Sciences
Author for correspondence.
Email: evkazn@incras.ru
Russian Federation
O. A. Zimina
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
L. N. Glushankova
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
J. A. Kolobkova
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
M. A. Ryazantseva
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
G. N. Mozhayeva
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
E. V. Kaznacheyeva
Institute of Cytology, Russian Academy of Sciences
Email: evkazn@incras.ru
Russian Federation
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