Regulation of Immunity via Multipotent Mesenchymal Stromal Cells

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Abstract

Immune cells responsible for inflammation development are involved in tissue damage caused by wounding and various pathologies. Control of immune cell activation could be of significant benefit for regenerative medicine and the treatment of patients with autoimmune and degenerative diseases. It is a proven fact that MCSs (multipotent mesenchymal stromal cells) are capable of suppressing immune responses via the inhibition of dendritic cell maturation and via the restraining of the T, B, and NK cell function in the course of autoimmune diseases and various forms of inflammation. MSCs can be isolated easily from almost every type of tissue or organ and subsequently expanded in vitro. These cells are self-renewable and can be differentiated into various cell types of mesenchymal lineage. The current review contains a collection and critical analysis of data regarding the molecular mechanisms responsible for cross-talk between immune cells and MSCs. Some of these mechanisms can be used for the development of new practical approaches for the treatment of autoimmune diseases.

About the authors

Yu. P. Rubtsov

Lomonosov Moscow State University

Author for correspondence.
Email: yrubtsov@gmail.com
Россия

Yu. G. Suzdaltseva

Institute of Experimental Cardiology

Email: yrubtsov@gmail.com
Россия

K. V. Goryunov

Lomonosov Moscow State University

Email: yrubtsov@gmail.com
Россия

N. I. Kalinina

Lomonosov Moscow State University

Email: yrubtsov@gmail.com
Россия

V. Yu. Sysoeva

Lomonosov Moscow State University

Email: yrubtsov@gmail.com
Россия

V. A. Tkachuk

Lomonosov Moscow State University

Email: yrubtsov@gmail.com
Россия

References

  1. Luria E.A., Panasyuk A.F., Friedenstein A.Y. // Transfusion. 1971. V. 11. P 345-349.
  2. Kassem M. // Cloning Stem Cells. 2004. V. 6. P 369-374.
  3. da Silva Meirelles L., Chagastelles P.C., Nardi N.B. // J. Cell Sci. 2006. V. 119. P 2204-2213.
  4. Kastrinaki M.C., Andreakou I., Charbord P., Papadaki H.A. // Tissue Eng. Part C Methods. 2008. V. 14. P. 333-339.
  5. Basciano L., Nemos C., Foliguet B., de Isla N., de Carvalho M., Tran N., Dalloul A. // BMC Cell Biol. 2011. V. 30. P. 12.
  6. Zimmermann S., Voss M., Kaiser S., Kapp U., Waller C.F., Martens U.M. // Leukemia. 2003. V. 17. P. 1146-1149.
  7. Tsai C.C., Chen C.L., Liu H.C., Lee Y.T., Wang H.W., Hou L.T., Hung S.C. // J. Biomed. Sci. 2010. V. 17. P 74.
  8. Haniffa M.A., Collin M.P., Buckley C.D., Dazzi F. // Haematologica. 2009. V. 94. P 258-263.
  9. Feng J., Mantesso A., De Bari C., Nishiyama A., Sharpe P.T. // Proc. Natl. Acad. Sci. USA. 2011. V. 108. P. 6503-6508.
  10. Augello A., Kurth T.B., De Bari C. // Eur. Cell Mater. 2010. V. 20. P 121-133.
  11. Jang K.S., Lee K.S., Yang S.H., Jeun S.S. // J. Korean Neurosurg. Soc. 2010. V. 48. P 391-398.
  12. Zimmermann C.E., Gierloff M., Hedderich J., Acil Y., Wiltfang J., Terheyden H. // Tissue Eng. Part A. 2011. V. 17. P. 1147-1156.
  13. Wei N., Gong P., Liao D., Yang X., Li X., Liu Y., Yuan Q., Tan Z. // Cytotherapy. 2010. V. 12. P. 514-521.
  14. Westrich J., Yaeger P., He C., Stewart J., Chen R., Seleznik G., Larson S., Wentworth B., O'Callaghan M., Wadsworth S., et al. // Cell Transplant. 2010. V. 19. P. 937-948.
  15. Sordi V. // Transplantation. 2009. V. 15. (9 Suppl). P 42-45.
  16. Lau T.T., Wang D.A. // Expert. Opin. Biol. Ther. 2011. V. 11. P. 189-197.
  17. Ponte A.L., Marais E., Gallay N., Langonné A., Delorme B., Hérault O., Charbord P., Domenech J. // Stem Cells. 2007. V. 25. P 1737-1745.
  18. Dwyer R.M., Potter-Beirne S.M., Harrington K.A., Lowery A.J., Hennessy E., Murphy J.M., Barry F.P., O'Brien T., Kerin M.J. // Clin. Cancer Res. 2007. V. 13. P. 5020-5027.
  19. Wynn R.F., Hart C.A., Corradi-Perini C., O'Neill L., Evans C.A., Wraith J.E., Fairbairn L.J., Bellantuono I. // Blood. 2004. V. 104. P 2643-2645.
  20. Bhakta S., Hong P., Koc O. // Cardiovasc. Revasc. Med. 2006. V. 7. P 19-24.
  21. Theiss H.D., Vallaster M., Rischpler C., Krieg L., Zaruba M.M., Brunner S., Vanchev Y., Fischer R., Gröbner M., Huber B., et al. // Stem Cell Res. 2011. V. 7. P 244-255.
  22. Mohty M., Ho A.D. // Exp. Hematol. 2011. V. 39. Р 723-729.
  23. Meyerrose T., Olson S., Pontow S., Kalomoiris S., Jung Y., Annett G., Bauer G., Nolta J.A. // Adv. Drug Deliv. Rev. 2010. V. 62. P. 1167-1174.
  24. Schneider R.K., Anraths J., Kramann R., Bornemann J., Bovi M., Knüchel R., Neuss S. // Biomaterials. 2010. V. 31. P. 7948-7959.
  25. Kasper G., Glaeser J.D., Geissler S., Ode A., Tuischer J., Matziolis G., Perka C., Duda G.N. // Stem Cells. 2007. V. 25. P. 1985-1994.
  26. Tapp H., Deepe R., Ingram J.A., Hanley E.N. Jr., Gruber H.E. // Arthritis Res. Ther. 2008. V. 10. P. R89.
  27. Joo S.Y., Cho K.A., Jung Y.J., Kim H.S., Park S.Y., Choi Y.B., Hong K.M., Woo S.Y., Seoh J.Y., Cho S.J., et al. // Cytotherapy. 2010. V. 12. P 361-370.
  28. Breitbart E.A., Meade S., Azad V., Yeh S., Al-Zube L., Lee Y.S., Benevenia J., Arinzeh T.L., Lin S.S. // J. Orthop. Res. 2010. V. 28. P. 942-949.
  29. Battiwalla M., Hematti P // Cytotherapy. 2009. V. 11. P 503-515.
  30. Park K.S., Kim Y.S., Kim J.H., Choi B., Kim S.H., Tan A.H., Lee M.S., Lee M.K., Kwon C.H., Joh J.W., et al. // Transplantation. 2010. V. 89. P 509-517.
  31. Kumar S., Wan C., Ramaswamy G., Clemens T.L., Ponnazhagan S. // Mol. Ther. 2010. V. 18. P. 1026-1034.
  32. Tang J., Wang J., Zheng F., Kong X., Guo L., Yang J., Zhang L., Huang Y. // Mol. Cell. Biochem. 2010. V. 339. P 107-118.
  33. Trzaska K.A., King C.C., Li K.Y., Kuzhikandathil E.V., Nowycky M.C., Ye J.H., Rameshwar P. // J. Neurochem. 2009. V. 110. P 1058-1069.
  34. Yang J., Wu H., Hu N., Gu X., Ding F. // Neurochem. Res. 2009. V. 34. P 1685-1694.
  35. Neuhuber B., Timothy Himes B., Shumsky J.S., Gallo G., Fischer I. // Brain Res. 2005. V. 1035. P 73-85.
  36. Burastero G., Scarfì S., Ferraris C., Fresia C., Sessarego N., Fruscione F., Monetti F., Scarfò F., Schupbach P., Podestà M., et al. // Bone. 2010. V. 47. P 117-126.
  37. Granero-Moltó F., Weis J.A., Miga M.I., Landis B., Myers T. J., O'Rear L., Longobardi L., Jansen E.D., Mortlock D.P., Spagnoli A. // Stem Cells. 2009. V. 27. P. 1887-1898.
  38. Osyczka A.M., Leboy P.S. // Endocrinology. 2005. V. 146. P. 3428-3437.
  39. Ioannou A., Dalle Lucca J., Tsokos G.C. // Clin. Immunol. 2011. V. 141. P 3-14.
  40. Maskrey B.H., Megson I.L., Whitfield P.D., Rossi A.G. // Arterioscler. Thromb. Vasc. Biol. 2011. V. 31. P. 1001-1006.
  41. Ratajczak M.Z., Kim C.H., Wojakowski W., Janowska-Wieczorek A., Kucia M., Ratajczak J. // Leukemia. 2010. V. 24. P 1667-1675.
  42. Iadecola C., Anrather J. // Nat. Med. 2011. V. 17. P. 796-808.
  43. Witte E., Witte K., Warszawska K., Sabat R., Wolk K. // Cytokine Growth Factor Rev. 2010. V. 21. P 365-379.
  44. Rouse B.T., Sehrawat S. // Nat. Rev. Immunol. 2010. V. 10. P. 514-526.
  45. Konkel J.E., Chen W. // Trends Mol. Med. 2011. V. 17. P. 668-676.
  46. Hoyne G.F. // Clin. Dev. Immunol. 2011. V. 2011. P. 2949-2968.
  47. Nurieva R.I., Liu X., Dong C. // Immunol. Rev. 2011. V. 241. P 133-144.
  48. Torchinsky M.B., Garaude J., Blander J.M. // Curr. Opin. Immunol. 2010. V. 22. P 55-62.
  49. Lei B., Hitomi H., Mori T., Nagai Y., Deguchi K., Mori H., Masaki T., Nakano D., Kobori H., Kitaura Y., et al. // J. Pharmacol. Sci. 2011. V. 117. P. 98-105.
  50. Gong K., Chen Y.F., Li P., Lucas J.A., Hage F.G., Yang Q., Nozell S.E., Oparil S., Xing D. // J. Hypertens. 2011. V. 29. P 1810-1819.
  51. Umemoto E., Hayasaka H., Bai Z., Cai L., Yonekura S., Peng X., Takeda A., Tohya K., Miyasaka M. // Crit. Rev. Immunol. 2011. V. 31. P 147-169.
  52. Marigo I., Dazzi F. // Semin. Immunopathol. 2011. V. 33. P. 593-602.
  53. Devine S.M., Cobbs C., Jennings M., Bartholomew A., Hoffman R. // Blood. 2003. V. 101. P 2999-3001.
  54. Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., Dazzi F. // Blood. 2003. V. 101. P 3722-3729.
  55. Liu H., Kemeny D.M., Heng B.C., Ouyang H.W., Melendez A.J., Cao T. // J. Immunol. 2006. V. 176. P. 2864-2871.
  56. Romieu-Mourez R., François M., Boivin M.N., Stagg J., Galipeau J. // J. Immunol. 2007. V. 179. P 1549-1558.
  57. Corcione A., Benvenuto F., Ferretti E., Giunti D., Cappiello V., Cazzanti F., Risso M., Gualandi F., Mancardi G.L., Pistoia V., et al. // Blood. 2006. V. 107. P. 367-372.
  58. Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P.D., Matteucci P., Grisanti S., Gianni A.M. // Blood. 2002. V. 99. P 3838-3843.
  59. Aggarwal S., Pittenger M.F. // Blood. 2005. V. 105. P 1815-1822.
  60. Zhang W., Ge W., Li C., You S., Liao L., Han Q., Deng W., Zhao R.C. // Stem Cells Dev. 2004. V. 13. P. 263-271.
  61. Le Blanc K., Rasmusson I., Götherstrom C., Seidel C., Sundberg B., Sundin M., Rosendahl K., Tammik C., Ringdén O. // Scand. J. Immunol. 2004. V. 60. P. 307-315.
  62. Nauta A.J., Kruisselbrink A.B., Lurvink E., Willemze R., Fibbe W.E. // J. Immunol. 2006. V. 177. P. 2080-2087.
  63. Jiang X.X., Zhang Y., Liu B., Zhang S.X., Wu Y., Yu X.D., Mao N. // Blood. 2005. V. 105. P. 4120-4126.
  64. Sotiropoulou P.A., Perez S.A., Gritzapis A.D., Baxevanis C.N., Papamichail M. // Stem Cells. 2006. V. 24. P 74-85.
  65. Selmani Z., Naji A., Zidi I., Favier B., Gaiffe E., Obert L., Borg C., Saas P., Tiberghien P., Rouas-Freiss N., et al. // Stem Cells. 2008. V. 26. P 212-222.
  66. Rasmusson I., Le Blanc K., Sundberg B., Ringdén O. // Scand. J. Immunol. 2007. V. 65. P. 336-343.
  67. Rafei M., Hsieh J., Fortier S., Li M., Yuan S., Birman E., Forner K., Boivin M.N., Doody K., Tremblay M., et al. // Blood. 2008. V. 112. P 4991-4998.
  68. Bartholomew A., Sturgeon C., Siatskas M., Ferrer K., McIntosh K., Patil S., Hardy W., Devine S., Ucker D., Deans R., et al. // Exp. Hematol. 2002. V. 30. P 42-48.
  69. Hemeda H., Jakob M., Ludwig A.K., Giebel B., Lang S., Brandau S. // Stem Cells Dev. 2010. V. 19. P 693-706.
  70. Ryan J.M., Barry F., Murphy J.M., Mahon B.P. // Clin. Exp. Immunol. 2007. V. 149. P 353-363.
  71. Du Y.Y., Zhou S.H., Zhou T., Su H., Pan H.W., Du W.H., Liu B., Liu Q.M. // Cytotherapy. 2008. V. 10. P. 469-478.
  72. Ortiz L.A., Dutreil M., Fattman C., Pandey A.C., Torres G., Go K., Phinney D.G. // Proc. Natl. Acad. Sci. USA. 2007. V. 104. P 11002-11007.
  73. Meisel R., Zibert A., Laryea M., Göbel U., Däubener W., Dilloo D. // Blood. 2004. V. 103. P. 4619-4621.
  74. Chen W. // Nat. Immunol. 2011. V. 12. P 809-811.
  75. Kang J.W., Kang K.S., Koo H.C., Park J.R., Choi E.W., Park Y.H. // Stem Cells Dev. 2008. V. 17. P. 681-693.
  76. Ren G., Zhang L., Zhao X., Xu G., Zhang Y., Roberts A.I., Zhao R.C., Shi Y. // Cell Stem Cell. 2008. V. 2. P. 141-150.
  77. Chen K., Wang D., Du W.T., Han Z.B., Ren H., Chi Y., Yang S.G., Zhu D., Bayard F., Han Z.C. // Clin. Immunol. 2010. V. 135. P. 448-458.
  78. Spaggiari G.M., Abdelrazik H., Becchetti F., Moretta L. // Blood. 2009. V. 113. P 6576-6583.
  79. Nasef A., Chapel A., Mazurier C., Bouchet S., Lopez M., Mathieu N., Sensebe L., Zhang Y., Gorin N.C., Thierry D., et al. // Gene Expr. 2007. V. 13. P. 217-226.
  80. Di Ianni M., Del Papa B., De Ioanni M., Moretti L., Bonifacio E., Cecchini D., Sportoletti P., Falzetti F., Tabilio A. // Exp. Hematol. 2008. V. 36. P. 309-318.
  81. Pevsner-Fischer M., Morad V., Cohen-Sfady M., Rousso-Noori L., Zanin-Zhorov A., Cohen S., Cohen I.R., Zipori D. // Blood. 2007. V. 109. P 1422-1432.
  82. Raicevic G., Najar M., Stamatopoulos B., De Bruyn C., Meuleman N., Bron D., Toungouz M., Lagneaux L. // Cell. Immunol. 2011. V. 270. P 207-216.
  83. Lei J., Wang Z., Hui D., Yu W., Zhou D., Xia W., Chen C., Zhang Q., Wang Z., Zhang Q., et al. // Cell. Immunol. 2011. V. 271. P 147-156.
  84. Raicevic G., Rouas R., Najar M., Stordeur P., Boufker H.I., Bron D., Martiat P., Goldman M., Nevessignsky M.T., Lagneaux L. // Hum. Immunol. 2010. V. 71. P. 235-244.
  85. Ren G., Zhao X., Zhang L., Zhang J., L'Huillier A., Ling W., Roberts A.I., Le A.D., Shi S., Shao C., et al. // J. Immunol. 2010. V. 184. P. 2321-2328.
  86. Najar M., Raicevic G., Id Boufker H., Stamatopoulos B., De Bruyn C., Meuleman N., Bron D., Toungouz M., Lagneaux L. // Exp. Hematol. 2010. V. 38. P 922-932.
  87. Le Blanc K., Rasmusson I., Sundberg B., Götherström C., Hassan M., Uzunel M., Ringdén O. // Lancet. 2004. V. 363. P 1439-1441.
  88. Le Blanc K., Frassoni F., Ball L., Locatelli F., Roelofs H., Lewis I., Lanino E., Sundberg B., Bernardo M.E., Remberger M., et al. // Lancet. 2008. V. 371. P. 1579-1586.
  89. Yañez R., Lamana M.L., García-Castro J., Colmenero I., Ramírez M., Bueren J.A. // Stem Cells. 2006. V. 24. P 2582-2591.
  90. Polchert D., Sobinsky J., Douglas G., Kidd M., Moadsiri A., Reina E., Genrich K., Mehrotra S., Setty S., Smith B., et al. // Eur. J. Immunol. 2008. V. 38. P. 1745-1755.
  91. Zappia E., Casazza S., Pedemonte E., Benvenuto F., Bonanni I., Gerdoni E., Giunti D., Ceravolo A., Cazzanti F., Frassoni F., et al. // Blood. 2005. V. 106. P 1755-1761.
  92. Rafei M., Campeau P.M., Aguilar-Mahecha A., Buchanan M., Williams P., Birman E., Yuan S., Young Y.K., Boivin M.N., Forner K., et al. // J. Immunol. 2009. V. 182. P. 5994-6002.
  93. Rafei M., Birman E., Forner K., Galipeau J. // Mol. Ther. 2009. V. 17. P 1799-1803.
  94. Gonzalez M.A., Gonzalez-Rey E., Rico L., Büscher D., Delgado M. // Arthritis Rheum. 2009. V. 60. P 1006-1019.
  95. Gonzalez-Rey E., Gonzalez M.A., Varela N., O'Valle F., Hernandez-Cortes P., Rico L., Büscher D., Delgado M. // Ann. Rheum. Dis. 2010. V. 69. P 241-248.
  96. Chen B., Hu J., Liao L., Sun Z., Han Q., Song Z., Zhao R.C. // Clin. Exp. Immunol. 2010. V. 159. P. 292-302.
  97. Semedo P., Palasio C.G., Oliveira C.D., Feitoza C.Q., Goncalves G.M., Cenedeze M.A., Wang P.M., Teixeira V.P., Reis M.A., Pacheco-Silva A., et al. // Int. Immunopharmacol. 2009. V. 9. P 677-682.
  98. Semedo P., Correa-Costa M., Antonio Cenedeze M., Maria Avancini Costa Malheiros D., Antonia dos Reis M., Shimizu M.H., Seguro A.C., Pacheco-Silva A., Saraiva Camara N.O. // Stem Cells. 2009. V. 27. P 3063-3073.
  99. Fiorina P., Jurewicz M., Augello A., Vergani A., Dada S., La Rosa S., Selig M., Godwin J., Law K., Placidi C., et al. // J. Immunol. 2009. V. 183. P 993-1004.
  100. Madec A.M., Mallone R., Afonso G., Abou Mrad E., Mesnier A., Eljaafari A., Thivolet C. // Diabetologia. 2009. V. 52. P 1391-1399.
  101. Boumaza I., Srinivasan S., Witt W.T., Feghali-Bostwick C., Dai Y., Garcia-Ocana A., Feili-Hariri M. // J. Autoimmun. 2009. V. 32. P 33-42.
  102. Tsukamoto S., Honoki K., Fujii H., Tohma Y., Kido A., Mori T., Tsujiuchi T., Tanaka Y. // Int. J. Oncol. 2012. V. 40.

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Copyright (c) 2012 Rubtsov Y.P., Suzdaltseva Y.G., Goryunov K.V., Kalinina N.I., Sysoeva V.Y., Tkachuk V.A.

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