Email this article Acadesine Triggers Non-apoptotic Death in Tumor Cells
- Authors: Glazunova V.A.1, Lobanov K.V.2, Shakulov R.S.2, Mironov A.S.2, Shtil A.A.1
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Affiliations:
- Blokhin Cancer Center, Russian Academy of Medical Sciences
- State Research Institute of Genetics and Selection of Industrial Microorganisms
- Issue: Vol 5, No 3 (2013)
- Pages: 74-78
- Section: Research Articles
- URL: https://actanaturae.ru/2075-8251/article/view/10586
- DOI: https://doi.org/10.32607/20758251-2013-5-3-74-78
- ID: 10586
Cite item
Abstract
We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter Р-glycoprotein or lack of proapoptotic p53. Activity of adenosine receptors was required for acadesine-induced cell death, whereas functioning of АМР-dependent protein kinase was not required. A more pronounced cytotoxicity for tumor cells, as well as the non-canonical death mechanism(s), makes acadesine a promising candidate for antitumor therapy.
Keywords
About the authors
V. A. Glazunova
Blokhin Cancer Center, Russian Academy of Medical Sciences
Author for correspondence.
Email: gav-83@mail.ru
Russian Federation
K. V. Lobanov
State Research Institute of Genetics and Selection of Industrial Microorganisms
Email: gav-83@mail.ru
Russian Federation
R. S. Shakulov
State Research Institute of Genetics and Selection of Industrial Microorganisms
Email: gav-83@mail.ru
Russian Federation
A. S. Mironov
State Research Institute of Genetics and Selection of Industrial Microorganisms
Email: gav-83@mail.ru
Russian Federation
A. A. Shtil
Blokhin Cancer Center, Russian Academy of Medical Sciences
Email: gav-83@mail.ru
Russian Federation
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