Neolactoferrin As a Stimulator of Innate and Adaptive Immunity

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Abstract

The effect of the innovative product Neolactoferrin, a natural combination of recombinant human lactoferrin (90%) and goat lactoferrin (10%) isolated from the milk of transgenic goats carrying the full-length human lactoferrin gene, on human immune system cells was studied. Neolactoferrin enhanced the production of IL-1β. Neolactoferrin saturated with iron ions increased the synthesis of pro-inflammatory cytokine TNFα. It determined the direction of the differentiation of precursor dendrite cells. Under the action of T cells, Neolactoferrin amplified the expression of the transcription factors responsible for the differentiation of Th- and Treg-cells and stimulated the production of both IFNγ and IL-4. The results suggest that Neolactoferrin exhibits an immunotropic activity and hinders the development of immune inflammatory processes. Iron saturation of Neolactoferrin increases its pro-inflammatory activity.

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Neolactoferrin As a Stimulator of Innate and Adaptive Immunity

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About the authors

A. D. Chernousov

Institute of Immunology, Federal Medical and Biological Agency

Author for correspondence.
Email: e.r.sadchikova@gmail.com
Russian Federation

M. F. Nikonova

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

N. I. Sharova

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

А. N. Mitin

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

М. М. Litvina

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

P. E. Sadchikov

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

I. L. Goldman

Institute of Immunology, Federal Medical and Biological Agency; Institute of Gene Biology, Russian Academy of Sciences

Email: e.r.sadchikova@gmail.com
Russian Federation

А. А. Yarilin

Institute of Immunology, Federal Medical and Biological Agency

Email: e.r.sadchikova@gmail.com
Russian Federation

Е. R. Sadchikova

Institute of Gene Biology, Russian Academy of Sciences

Email: e.r.sadchikova@gmail.com
Russian Federation

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Copyright (c) 2013 Chernousov A.D., Nikonova M.F., Sharova N.I., Mitin А.N., Litvina М.М., Sadchikov P.E., Goldman I.L., Yarilin А.А., Sadchikova Е.R.

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