Experimental Use of Common Marmosets (Callithrix jacchus) in Preclinical Trials of Antiviral Vaccines
- Authors: Gordeychuk I.V.1,2, Gancharova О.S.1,3, Gulyaev S.A.1, Gulyaeva Т.V.1, Zhitkevich A.S.1, Avdoshina D.V.1, Moroz A.V.1, Lunin A.S.1, Sotskova S.E.1, Korduban E.A.1, Tukhvatulin A.I.4, Bayurova E.O.1, Ishmukhametov A.A.1,2
-
Affiliations:
- Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
- Sechenov University
- M.V. Lomonosov Moscow State University
- National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation
- Issue: Vol 16, No 2 (2024)
- Pages: 30-39
- Section: Research Articles
- Submitted: 22.01.2024
- Accepted: 12.08.2024
- Published: 21.08.2024
- URL: https://actanaturae.ru/2075-8251/article/view/27372
- DOI: https://doi.org/10.32607/actanaturae.27372
- ID: 27372
Cite item
Abstract
Common marmoset (Callithrix jacchus, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials.
About the authors
I. V. Gordeychuk
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov University
Author for correspondence.
Email: gordeychuk_iv@chumakovs.su
Institute for Translational Medicine and Biotechnology
Russian Federation, Moscow, 108819; Moscow, 117418О. S. Gancharova
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; M.V. Lomonosov Moscow State University
Email: gordeychuk_iv@chumakovs.su
Belozersky Institute of Physico-Chemical Biology
Russian Federation, Moscow, 108819; Moscow, 119992S. A. Gulyaev
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
Т. V. Gulyaeva
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
A. S. Zhitkevich
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
D. V. Avdoshina
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
A. V. Moroz
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
A. S. Lunin
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
S. E. Sotskova
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
E. A. Korduban
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
A. I. Tukhvatulin
National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 123098
E. O. Bayurova
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
Email: gordeychuk_iv@chumakovs.su
Russian Federation, Moscow, 108819
A. A. Ishmukhametov
Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov University
Email: gordeychuk_iv@chumakovs.su
Institute for Translational Medicine and Biotechnology
Russian Federation, Moscow, 108819; Moscow, 117418References
- Heijmans C.M.C., de Groot N.G., Bontrop R.E. // Int. J. Immunogenet. 2020. V. 47. № 3. P. 243–260.
- ‘t Hart B.A., Abbott D.H., Nakamura K., Fuchs E. // Drug Discov. Today. 2012. V. 17. № 21–22. P. 1160–1165.
- Bayurova E., Zhitkevich A., Avdoshina D., Kupriyanova N., Kolyako Y., Kostyushev D., Gordeychuk I. // Cells. 2023. V. 12. № 16. P. 2020.
- Tardif S.D., Smucny D.A., Abbott D.H., Mansfield K., Schultz-Darken N., Yamamoto M.E. // Comparative Medicine. 2003. V. 53. № 4. P. 364–368.
- Antunes S.G., de Groot N.G., Brok H., Doxiadis G., Menezes A.A., Otting N., Bontrop R.E. // Proc. Natl. Acad. Sci. USA. 1998. V. 95. № 20. P. 11745–11750.
- Cao Y.H., Fan J.W., Li A.X., Liu H.F., Li L.R., Zhang C.L., Zeng L., Sun Z.Z. // Am. J. Primatol. 2015. V. 77. № 5. P. 527–534.
- Carrion R., Patterson J.L. // Curr. Opin. Virol. 2012. V. 2. № 3. P. 357–362.
- Marmoset Genome Sequencing and Analysis Consortium // Nat. Genet. 2014. V. 46. № 8. P. 850–857.
- Sasaki E., Suemizu H., Shimada A., Hanazawa K., Oiwa R., Kamioka M., Tomioka I., Sotomaru Y., Hirakawa R., Eto T., et al. // Nature. 2009. V. 459. № 7246. P. 523–527.
- Tukhvatulin A.I., Gordeychuk I.V., Dolzhikova I.V., Dzharullaeva A.S., Krasina M.E., Bayurova E.O., Grousova D.M., Kovyrshina A.V., Kondrashova A.S., Avdoshina D.V., et al. // Emerg. Microbes Infect. 2022. V. 11. № 1. P. 2229–2247.
- Kozlovskaya L.I., Piniaeva A.N., Ignatyev G.M., Gordeychuk I.V., Volok V.P., Rogova Y.V., Shishova A.A., Kovpak A.A., Ivin Y.Y., Antonova L.P., et al. // Emerg. Microbes Infect. 2021. V. 10. № 1. P. 1790–1806.
- Kaspareit J., Friderichs-Gromoll S., Buse E., Habermann G. // Exp. Toxicol. Pathol. 2006. V. 57. № 5–6. P. 405–410.
- Pearse G. // Toxicol. Pathol. 2006. V. 34. № 5. P. 504–514.
- David J.M., Dick E.J., Hubbard G.B. // J. Med. Primatol. 2009. V. 38. № 5. P. 347–359.
- Gordeychuk I.V., Kozlovskaya L.I., Siniugina A.A., Yagovkina N.V., Kuzubov V.I., Zakharov K.A., Volok V.P., Dodina M.S., Gmyl L.V., Korotina N.A., et al. // Viruses. 2023. V. 15. № 9. P. 1828.
- Dolzhikova I.V., Grousova D.M., Zubkova O.V., Tukhvatulin A.I., Kovyrshina A.V., Lubenets N.L., Ozharovskaia T.A., Popova O., Esmagambetov I.B., Shcheblyakov D.V., et al. // Acta Naturae. 2020. V. 12. № 3. P. 114–123.
- Gordeychuk I., Kyuregyan K., Kondrashova A., Bayurova E., Gulyaev S., Gulyaeva T., Potemkin I., Karlsen A., Isaeva O., Belyakova A., et al. // Vaccine. 2022. V. 40. № 1. P. 89–99.
Supplementary files
![](/img/style/loading.gif)