Experimental Use of Common Marmosets ( Callithrix jacchus ) in Preclinical Trials of Antiviral Vaccines

I. V. Gordeychuk; Гордейчук И. В.; О. S. Gancharova; Ганчарова О. С.; S. A. Gulyaev; Гуляев С. А.; Т. V. Gulyaeva; Гуляева Т. В.; A. S. Zhitkevich; Житкевич А. С.; D. V. Avdoshina; Авдошина Д. В.; A. V. Moroz; Мороз А. В.; A. S. Lunin; Лунин А. С.; S. E. Sotskova; Соцкова С. Е.; E. A. Korduban; Кордубан Е. А.; A. I. Tukhvatulin; Тухватулин А. И.; E. O. Bayurova; Баюрова Е. О.; A. A. Ishmukhametov; Ишмухаметов А. А.

doi:10.32607/actanaturae.27372

Experimental Use of Common Marmosets (Callithrix jacchus) in Preclinical Trials of Antiviral Vaccines

Authors: Gordeychuk I.V.¹^,2, Gancharova О.S.¹^,3, Gulyaev S.A.¹, Gulyaeva Т.V.¹, Zhitkevich A.S.¹, Avdoshina D.V.¹, Moroz A.V.¹, Lunin A.S.¹, Sotskova S.E.¹, Korduban E.A.¹, Tukhvatulin A.I.⁴, Bayurova E.O.¹, Ishmukhametov A.A.¹^,2
Affiliations:
1. Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences
2. Sechenov University
3. M.V. Lomonosov Moscow State University
4. National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation
Issue: Vol 16, No 2 (2024)
Pages: 30-39
Section: Research Articles
Submitted: 22.01.2024
Accepted: 12.08.2024
Published: 21.08.2024
URL: https://actanaturae.ru/2075-8251/article/view/27372
DOI: https://doi.org/10.32607/actanaturae.27372
ID: 27372

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Abstract

Common marmoset (Callithrix jacchus, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials.

Keywords

laboratory primates, Callithrix jacchus, laboratory breeding of primates, antiviral vaccines, safety and immunogenicity of vaccines

About the authors

I. V. Gordeychuk

Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Sechenov University

Author for correspondence.
Email: gordeychuk_iv@chumakovs.su

Institute for Translational Medicine and Biotechnology

Russian Federation, Moscow, 108819; Moscow, 117418

О. S. Gancharova

Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; M.V. Lomonosov Moscow State University

Email: gordeychuk_iv@chumakovs.su

Belozersky Institute of Physico-Chemical Biology

Russian Federation, Moscow, 108819; Moscow, 119992

Institute for Translational Medicine and Biotechnology

Russian Federation, Moscow, 108819; Moscow, 117418

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