Deficient Response to Experimentally Induced Alkalosis in Mice with the Inactivated insrr Gene

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Abstract

Currently, the molecular mechanisms of the acid-base equilibrium maintenance in the body remain poorly understood. The development of alkalosis under various pathological conditions poses an immediate threat to human life. Understanding the physiological mechanisms of alkalosis compensation may stimulate the development of new therapeutic approaches and new drugs for treatment. It was previously shown that the orphan insulin receptor-related receptor (IRR) is activated by mildly alkaline media. In this study, we analyzed mutant mice with targeted inactivation of the insrr gene encoding IRR, and revealed their phenotype related to disorders of the acid-base equilibrium. Higher concentrations of bicarbonate and CO 2 were found in the blood of insrr knockout mice in response to metabolic alkalosis.

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Deficient Response to Experimentally Induced Alkalosis in Mice with the Inactivated insrr Gene
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About the authors

I E Deyev

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

D I Rzhevsky

Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry

Pushchino, Russian

A A Berchatova

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

O V Serova

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

N V Popova

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

A N Murashev

Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry

Pushchino, Russian

A G Petrenko

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: petrenkoag@gmail.com

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Copyright (c) 2011 Deyev I.E., Rzhevsky D.I., Berchatova A.A., Serova O.V., Popova N.V., Murashev A.N., Petrenko A.G.

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