NAD+-dependent Formate Dehydrogenase from Plants

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Abstract

NAD +-dependent formate dehydrogenase (FDH, EC 1.2.1.2) widely occurs in nature. FDH consists of two identical subunits and contains neither prosthetic groups nor metal ions. This type of FDH was found in different microorganisms (including pathogenic ones), such as bacteria, yeasts, fungi, and plants. As opposed to microbiological FDHs functioning in cytoplasm, plant FDHs localize in mitochondria. Formate dehydrogenase activity was first discovered as early as in 1921 in plant; however, until the past decade FDHs from plants had been considerably less studied than the enzymes from microorganisms. This review summarizes the recent results on studying the physiological role, properties, structure, and protein engineering of plant formate dehydrogenases.

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NAD+-dependent Formate Dehydrogenase from Plants
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About the authors

A A Alekseeva

Lomonosov Moscow State University; Innovations and High Technologies MSU Ltd; Bach Institute of Biochemistry, Russian Academy of Sciences

Chemistry Department

S S Savin

Innovations and High Technologies MSU Ltd; Bach Institute of Biochemistry, Russian Academy of Sciences

V I Tishkov

Lomonosov Moscow State University; Innovations and High Technologies MSU Ltd; Bach Institute of Biochemistry, Russian Academy of Sciences

Email: vitishkov@gmail.com
Chemistry Department

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