Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity

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Abstract

9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC50 = 500 μM) and to have no significant effects on the growth of Mycobacterium tuberculosis.

About the authors

E. S. Matyugina

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Author for correspondence.
Email: khandazhinskaya@bk.ru
Россия

S. N. Andreevskaya

Central Tuberculosis Research Institute, Russian Academy of Medical Sciences

Email: khandazhinskaya@bk.ru
Россия

T. G. Smirnova

Central Tuberculosis Research Institute, Russian Academy of Medical Sciences

Email: khandazhinskaya@bk.ru
Россия

A. L. Khandazhinskaya

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Россия

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Copyright (c) 2012 Matyugina E.S., Andreevskaya S.N., Smirnova T.G., Khandazhinskaya A.L.

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