Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin

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The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat’s liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.

Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin

T. N. Popova

Voronezh State University

Author for correspondence.

Russian Federation

A. A. Agarkov

Voronezh State University


Russian Federation

A. N. Verevkin

Voronezh State University


Russian Federation

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Copyright (c) 2013 Popova T.N., Agarkov A.A., Verevkin A.N.

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