Email this article Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
- Authors: Popova T.N.1, Agarkov A.A.1, Verevkin A.N.1
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Affiliations:
- Voronezh State University
- Issue: Vol 5, No 4 (2013)
- Pages: 118-122
- Section: Research Articles
- Submitted: 17.01.2020
- Published: 15.12.2013
- URL: https://actanaturae.ru/2075-8251/article/view/10584
- DOI: https://doi.org/10.32607/20758251-2013-5-4-118-122
- ID: 10584
Cite item
Abstract
The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat’s liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.
Full Text
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin
About the authors
T. N. Popova
Voronezh State University
Author for correspondence.
Email: wer.all@mail.ru
Russian Federation
A. A. Agarkov
Voronezh State University
Email: wer.all@mail.ru
Russian Federation
A. N. Verevkin
Voronezh State University
Email: wer.all@mail.ru
Russian Federation
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