AZT 5’-Phosphonates: Achievements and Trends in the Treatment and Prevention of HIV Infection
- Authors: Khandazhinskaya А.L.1, Shirokova E.A.1
-
Affiliations:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Issue: Vol 5, No 3 (2013)
- Pages: 54-61
- Section: Reviews
- Submitted: 17.01.2020
- Published: 15.09.2013
- URL: https://actanaturae.ru/2075-8251/article/view/10583
- DOI: https://doi.org/10.32607/20758251-2013-5-3-54-61
- ID: 10583
Cite item
Abstract
Despite the numerous drawbacks, 3’-azido-3’-deoxythymidine (AZT, Zidovudine, Retrovir) remains one of the key drugs used in the treatment and prevention of HIV infection in both monotherapy and HAART. A strategy in searching for new effective and safe AZT agents among latent (depot) forms of AZT has yielded its first positive results. In particular, the sodium salt of AZT 5’-H-phosphonate (Nikavir, phosphazide) has demonstrated clinical advantages over parent AZT: first and foremost, lower toxicity and better tolerability. It can be effectively used for the prevention of vertical transmission from mothers to babies and as an alternative drug for HIV-infected patients with low tolerance to Zidovudine. Preclinical studies of another phosphonate, AZT 5’-aminocarbonylphosphonate, have demonstrated that it releases AZT when taken orally. Pharmacokinetic studies have shown a prolonged action potential. Based on the analysis of both toxicological and pharmacological data, AZT 5’-aminocarbonylphosphonate has been recommended for clinical trials.
About the authors
А. L. Khandazhinskaya
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Author for correspondence.
Email: khandazhinskaya@bk.ru
Россия
E. A. Shirokova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: khandazhinskaya@bk.ru
Россия
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