Aptamers: Problems, Solutions and Prospects

Cover Page

Cite item

Full Text

Abstract

Aptamers are short single-stranded oligonucleotides that are capable of binding various molecules with high affinity and specificity. When the technology of aptamer selection was developed almost a quarter of a century ago, a suggestion was immediately put forward that it might be a revolutionary start into solving many problems associated with diagnostics and the therapy of diseases. However, multiple attempts to use aptamers in practice, although sometimes successful, have been generally much less efficient than had been expected initially. This review is mostly devoted not to the successful use of aptamers but to the problems impeding the widespread application of aptamers in diagnostics and therapy, as well as to approaches that could considerably expand the range of aptamer application.

Full Text

Aptamers: Problems, Solutions and Prospects

×

About the authors

A. V. Lakhin

Institute of Molecular Genetics, Russian Academy of Sciences

Author for correspondence.
Email: lahin9@mail.ru
Россия

V. Z. Tarantul

Institute of Molecular Genetics, Russian Academy of Sciences

Email: lahin9@mail.ru
Россия

L. V. Gening

Institute of Molecular Genetics, Russian Academy of Sciences

Email: lahin9@mail.ru
Россия

References

  1. Gilbert W. // Nature 1986, V.319, P.618
  2. Gold L., Janjic N., Jarvis T., Schneider D., Walker J.J., Wilcox S.K., Zichi D. // Cold Spring. Harb. Perspect. Biol. 2012, V.4, P.a003582
  3. Cheng L.K., Unrau P.J. // Cold Spring. Harb. Perspect. Biol. 2010, V.2, P.a002204
  4. Song K.M., Lee S., Ban C. // Sensors (Basel). 2012, V.12, P.612-631
  5. Burnett J.C., Rossi J.J. // Chem. Biol. 2012, V.19, P.60-71
  6. Conrad R.C., Giver L., Tian Y., Ellington A.D. // Meth. Enzymol. 1996, V.267, P.336-367
  7. Kulbachinskiy A.V. // Biochemistry (Moscow). 2007, V.72, P.1505-1518
  8. Bouchard P.R., Hutabarat R.M., Thompson K.M. // Annu. Rev. Pharmacol. Toxicol. 2010, V.50, P.237-257
  9. Cibiel A., Pestourie C., Ducongé F. // Biochimie. 2012, V.94, P.1595-1606
  10. Yang L., Zhang X., Ye M., Jiang J., Yang R., Fu T., Chen Y., Wang K., Liu C., Tan W. // Adv. Drug. Deliv. Rev. 2011, V.63, P.1361-1370
  11. Ellington A.D., Szostak J.W. // Nature 1990, V.346, P.818-822
  12. Tuerk C., Gold L. // Science. 1990, V.249, P.505-510
  13. Hermann T., Patel D.J. // Science. 2000, V.287, P.820-825
  14. Nakamura Y., Ishiguro A., Miyakawa S. // Genes Cells. 2012, V.17, P.344-364
  15. Marimuthu C., Tang T.H., Tominaga J., Tan S.C., Gopinath S.C. // Analyst. 2012, V.137, P.1307-1315
  16. Mascini M., Palchetti I., Tombelli S. // Angew. Chem. Int. Ed. Engl. 2012, V.51, P.1316-1332
  17. Liu J., You M., Pu Y., Liu H., Ye M., Tan W. // Curr. Med. Chem. 2011, V.18, P.4117-4125
  18. Feldheim D.L., Eaton B.E. // ACS Nano. 2007, V.1, P.154-159
  19. Zaher H.S., Unrau P.J. // RN A. 2007, V.13, P.1017-1026
  20. Yan X., Gao X., Zhang Z. // Genomics Proteomics Bioinformatics. 2004, V.2, P.32-42
  21. Kuwahara M., Sugimoto N. // Molecules. 2010, V.15, P.5423-5444
  22. Li N., Nguyen H.H., Byrom M., Ellington A.D. // PLoS One. 2011, V.6, P.e20299
  23. Derbyshire N., White S.J., Bunka D.H., Song L., Stead S., Tarbin J., Sharman M., Zhou D., Stockley P.G. // Anal. Chem. 2012, V.84, P.6595-6602
  24. Lebars I., Richard T., Di Primo C., Toulmé J.J. // Blood Cells Mol. Dis. 2007, V.38, P.204-209
  25. Hernandez F.J., Stockdale K.R., Huang L., Horswill A.R., Behlke M.A., McNamara J.O. 2nd. // Nucl. Acid Ther. 2012, V.22, P.58-68
  26. Siddiqui M.A., Keating G.M. // Drugs. 2005, V.65, P.1571-1579
  27. Mayer G. // Angew. Chem. Int. Ed. Engl. 2009, V.48, P.2672-2689
  28. Nitsche A., Kurth A., Dunkhorst A., Pänke O., Sielaff H., Junge W., Muth D., Scheller F., Stöcklein W., Dahmen C. // BMC Biotechnol. 2007, V.7, P.48
  29. Mori Y., Nakamura Y., Ohuchi S. // Biochem. Biophys. Res. Commun. 2012, V.420, P.440-443
  30. Di Giusto D.A., Knox S.M., Lai Y., Tyrelle G.D., Aung M.T., King G.C. // Chembiochem. 2006, V.7, P.535-544
  31. Levin A.A. // Biochim. Biophys. Acta. 1999, V.1489, P.69-84
  32. Eulberg D., Klussmann S. // ChemBioChem. 2003, V.4, P.979-983
  33. Turner J.J., Hoos J.S., Vonhoff S., Klussmann S. // Nucleic Acids Research 2011, V.39, P.e147
  34. Hafner M., Vianini E., Albertoni B., Marchetti L., Grune I., Gloeckner C., Famulok M. // Nature Protocols 2008, V.3, P.579-587
  35. Yamazaki S., Tan L., Mayer G., Hartig J.S., Song J.N., Reuter S., Restle T., Laufer S.D., Grohmann D., Krausslich H.G. // Chem. Biol. 2007, V.14, P.804-812
  36. Pasut G., Veronese F.M. // J. Control. Release. 2012, V.161, P.461-472
  37. Milla P., Dosio F., Cattel L. // Curr. Drug Metab. 2012, V.13, P.105-119
  38. Tan L., Neoh K.G., Kang E.T., Choe W.S., Su X. // Macromol. Biosci. 2011, V.11, P.1331-1335
  39. Boomer R.M., Lewis S.D., Healy J.M., Kurz M., Wilson C., McCauley T.G. // Oligonucleotides. 2005, V.15, P.183-195
  40. Rusconi C.P., Roberts J.D., Pitoc G.A., Nimjee S.M., White R.R., Quick G. Jr., Scardino E., Fay W.P., Sullenger B.A. // Nat. Biotechnol. 2004, V.22, P.1423-1428
  41. Rusconi C.P., Scardino E., Layzer J., Pitoc G.A., Ortel T.L., Monroe D., Sullenger B.A. // Nature 2002, V.419, P.90-94
  42. Bompiani K.M., Monroe D.M., Church F.C., Sullenger B.A. // J. Thromb. Haemost. 2012, V.10, P.870-880
  43. Oney S., Lam R.T., Bompiani K.M., Blake C.M., Quick G., Heidel J.D., Liu J.Y., Mack B.C., Davis M.E., Leong K.W. // Nat. Med. 2009, V.15, P.1224-1228
  44. Bompiani K.M., Woodruff R.S., Becker R.C., Nimjee S.M., Sullenger B.A. // Curr. Pharm. Biotechnol. 2012, V.13, P.1924-1934
  45. Davis M.E., Pun S.H., Bellocq N.C., Reineke T.M., Popielarski S.R., Mishra S., Heidel J.D. // Curr. Med. Chem. 2004, V.11, P.179-197
  46. Mao H.Q., Leong K.W. // Adv. Genet. 2005, V.53, P.275-306
  47. Joachimi A., Mayer G., Hartig J.S. // J. Am. Chem. Soc. 2007, V.129, P.3036-3037
  48. Buff M.C., Schäfer F., Wulffen B., Müller J., Pötzsch B., Heckel A., Mayer G. // Nucleic Acids Research 2010, V.38, P.2111-2118
  49. Brieke C., Rohrbach F., Gottschalk A., Mayer G., Heckel A. // Angew. Chem. Int. Ed. Engl. 2012, V.51, P.8446-8476
  50. Good P.D., Krikos A.J., Li S.X., Bertrand E., Lee N.S., Giver L., Ellington A., Zaia J.A., Rossi J.J., Engelke D.R. // Gene Ther. 1997, V.4, P.45-54
  51. Ausländer D., Wieland M., Ausländer S., Tigges M., Fussenegger M. // Nucleic Acids Research 2011, V.39, P.e155
  52. Chaloin L., Lehmann M.J., Sczakiel G., Restle T. // Nucleic Acids Research 2002, V.30, P.4001-4008
  53. Mi J., Zhang X., Rabbani Z.N., Liu Y., Su Z., Vujaskovic Z., Kontos C.D., Sullenger B.A., Clary B.M. // Nucleic Acids Research 2006, V.34, P.3577-3584
  54. Mayer G., Blind M., Nagel W., Böhm T., Knorr T., Jackson C.L., Kolanus W., Famulok M. // Proc. Natl. Acad. Sci. USA. 2001, V.98, P.4961-4965
  55. Davydova A.S., Vorobjeva M.A., Venyaminova A.G. // Acta Naturae. 2011, V.3, №4(11), P.12-29
  56. Meyer C., Eydeler K., Magbanua E., Zivkovic T., Piganeau N., Lorenzen I., Grötzinger J., Mayer G., Rose-John S., Hahn U. // RN A Biol. 2012, V.9, P.67-80
  57. Zhao Y., Duan S., Zeng X., Liu C., Davies N.M., Li B., Forrest M.L. // Mol. Pharm. 2012, V.9, P.1705-1716
  58. Min K., Jo H., Song K., Cho M., Chun Y.S., Jon S., Kim W.J., Ban C. // Biomaterials. 2011, V.32, P.2124-2132
  59. Liu Y., Kuan C.T., Mi J., Zhang X., Clary B.M., Bigner D.D., Sullenger B.A. // Biol. Chem. 2009, V.390, P.137-144
  60. Sun W., Du L., Li M. // Curr. Pharm. Des. 2011, V.17, P.80-91
  61. Ye M., Hu J., Peng M., Liu J., Liu J., Liu H., Zhao X., Tan W. // Int. J. Mol. Sci. 2012, V.13, P.3341-3353
  62. Göringer H.U. // Trends Parasitol. 2012, V.28, P.106-113
  63. Moreno M., González V.M. // Curr. Med. Chem. 2011, V.18, P.5003-5010
  64. Wan Y., Liu Y., Allen P.B., Asghar W., Mahmood M.A., Tan J., Duhon H., Kim Y.T., Ellington A.D., Iqbal S.M. // Lab. Chip. 2012, V.12, P.4693-4701
  65. Sheng W., Chen T., Kamath R., Xiong X., Tan W., Fan Z.H. // Anal. Chem. 2012, V.84, P.4199-4206
  66. Javier D.J., Nitin N., Levy M., Ellington A., Richards-Kortum R. // Bioconjug. Chem. 2008, V.19, P.1309-1312
  67. Khan S.A., Kanchanapally R., Fan Z., Beqa L., Singh A.K., Senapati D., Ray P.C. // Chem. Commun. (Camb.) 2012, V.48, P.6711-6713
  68. Kanoatov M., Javaherian S., Krylov S.N. // Anal. Chim. Acta. 2010, V.681, P.92-97
  69. Javaherian S., Musheev M.U., Kanoatov M., Berezovski M.V., Krylov S.N. // Nucleic Acids Research 2009, V.37, P.e62
  70. Han B., Zhao C., Yin J., Wang H. // J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2012, V.903, P.112-117
  71. Arnau J., Lauritzen C., Petersen G.E., Pedersen J. // Protein Expr. Purif. 2006, V.48, P.1-13
  72. Mi J., Liu Y., Rabbani Z.N., Yang Z., Urban J.H., Sullenger B.A., Clary B.M. // Nat. Chem. Biol. 2010, V.6, P.22-24
  73. Gening L.V., Klincheva S.A., Reshetnjak A., Grollman A.P., Miller H. // Nucleic Acids Research 2006, V.34, P.2579-2586
  74. Lakhin A.V., Kazakov A.A., Makarova A.V., Pavlov Y.I., Efremova A.S., Shram S.I., Tarantul V.Z., Gening L.V. // Nucl. Acid Ther. 2012, V.22, P.49-57
  75. Cox J.C., Ellington A.D. // Bioorg. Med. Chem. 2001, V.9, P.2525-2531
  76. Eulberg D., Buchner K., Maasch C., Klussmann S. // Nucleic Acids Research 2005, V.33, P.e45
  77. Berezovski M., Drabovich A., Krylova S.M., Musheev M., Okhonin V., Petrov A., Krylov S.N. // J. Am. Chem. Soc. 2005, V.127, P.3165-3171
  78. Drabovich A.P., Berezovski M., Okhonin V., Krylov S.N. // Anal. Chem. 2006, V.78, P.3171-3178
  79. Soontornworajit B., Wang Y. // Anal. Bioanal. Chem. 2011, V.399, P.1591-1599
  80. Hong P., Li W., Li J. // Sensors (Basel). 2012, V.12, P.1181-1193
  81. Shin S., Kim I.H., Kang W., Yang J.K., Hah S.S. // Bioorg. Med. Chem. Lett. 2010, V.20, P.3322-3325
  82. Lee S., Song K.M., Jeon W., Jo H., Shim Y.B., Ban C. // Biosens. Bioelectron. 2012, V.35, P.291-296
  83. Wang Y., Xu D., Chen H.Y. // Lab. Chip. 2012, V.12, P.3184-3189
  84. Tan X., Chen W., Lu S., Zhu Z., Chen T., Zhu G., You M., Tan W. // Anal. Chem. 2012, V.84, P.8272-8276
  85. Orozco J., Campuzano S., Kagan D., Zhou M., Gao W., Wang J. // Anal. Chem. 2011, V.83, P.7962-7969
  86. Kökpinar O., Walter J.G., Shoham Y., Stahl F., Scheper T. // Biotechnology and Bioengineering 2011, V.108, P.2371-2379
  87. Bruno J.G., Richarte A.M., Carrillo M.P., Edge A. // Biosens. Bioelectron. 2012, V.31, P.240-243
  88. Lauridsen L.H., Shamaileh H.A., Edwards S.L., Taran E., Veedu R.N. // PLoS One. 2012, V.7, P.e41702
  89. Huang Y., Zhao S., Chen Z.F., Shi M., Liang H. // Chem. Commun. (Camb.) 2012, V.48, P.7480-7482
  90. Han K., Liang Z., Zhou N. // Sensors. 2010, V.10, P.4541-4557
  91. Ocaña C., Pacios M., del Valle M. // Sensors (Basel). 2012, V.12, P.3037-3048
  92. Feng L., Chen Y., Ren J., Qu X. // Biomaterials. 2011, V.32, P.2930-2937
  93. Missailidis S., Hardy A. // Expert. Opin. Ther. Pat. 2009, V.19, P.1073-1082
  94. Huang Y.Z., Hernandez F.J., Gu B., Stockdale K.R., Nanapaneni K., Scheetz T.E., Behlke M.A., Peek A.S., Bair T., Giangrande P.H. // Mol. Pharmacol. 2012, V.82, P.623-635
  95. Pastor F., Kolonias D., McNamara J.O. 2nd., Gilboa E. // Molecular Therapy 2011, V.19, P.1878-1886
  96. Zeller S.J., Kumar P. // Yale J. Biol. Med. 2011, V.84, P.301-309
  97. Binning J.M., Leung D.W., Amarasinghe G.K. // Front. Microbiol. 2012, V.3, P.29
  98. Gopinath S.C., Hayashi K., Kumar P.K. // Virology Journal 2012, V.86, P.6732-6744
  99. Mufhandu H.T., Gray E.S., Madiga M.C., Tumba N., Alexandre K.B., Khoza T., Wibmer C.K., Moore P.L., Morris L., Khati M. // Virology Journal 2012, V.86, P.4989-4999
  100. Zhang Y., Hong H., Cai W. // Curr. Med. Chem. 2011, V.18, P.4185-4194
  101. Orava E.W., Cicmil N., Gariépy J. // Biochim. Biophys. Acta. 2010, V.1798, P.2190-2200
  102. Zhu Q., Shibata T., Kabashima T., Kai M. // Eur. J. Med. Chem. 2012, V.56, P.396-399
  103. Neff C.P., Zhou J., Remling L., Kuruvilla J., Zhang J., Li H., Smith D.D., Swiderski P., Rossi J.J., Akkina R. // Sci. Transl. Med. 2011, V.3, P.66ra6
  104. Yu B., Tai H.C., Xue W., Lee L.J., Lee R.J. // Mol. Membr. Biol. 2010, V.27, P.286-298
  105. Talekar M., Kendall J., Denny W., Garg S. // Anticancer Drugs. 2011, V.22, P.949-962
  106. Aravind A., Jeyamohan P., Nair R., Veeranarayanan S., Nagaoka Y., Yoshida Y., Maekawa T., Kumar D.S. // Biotechnology and Bioengineering 2012, V.109, P.2920-2931
  107. Kang H., O’Donoghue M.B., Liu H., Tan W. // Chem. Commun. (Camb.) 2010, V.46, P.249-251
  108. Chen C.H., Dellamaggiore K.R., Ouellette C.P., Sedano C.D., Lizadjohry M., Chernis G.A., Gonzales M., Baltasar F.E., Fan A.L., Myerowitz R. // Proc. Natl. Acad. Sci. USA. 2008, V.105, P.15908-15913
  109. Dombi T., Kwok K.K., Sultan M.B. // BMC Ophthalmol. 2012, V.12, P.37

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Lakhin A.V., Tarantul V.Z., Gening L.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies