“Epigenetic Memory” Phenomenon in Induced Pluripotent Stem Cells

Cover Page

Cite item

Full Text

Abstract

To date biomedicine and pharmacology have required generating new and more consummate models. One of the most perspective trends in this field is using induced pluripotent stem cells (iPSCs). iPSC application requires careful high-throughput analysis at the molecular, epigenetic, and functional levels. The methods used have revealed that the expression pattern of genes and microRNA, DNA methylation, as well as the set and pattern of covalent histone modifications in iPSCs, are very similar to those in embryonic stem cells. Nevertheless, iPSCs have been shown to possess some specific features that can be acquired during the reprogramming process or are remnants of epigenomes and transcriptomes of the donor tissue. These residual signatures of epigenomes and transcriptomes of the somatic tissue of origin were termed “epigenetic memory.” In this review, we discuss the “epigenetic memory” phenomenon in the context of the reprogramming process, its influence on iPSC properties, and the possibilities of its application in cell technologies.

Full Text

“Epigenetic Memory” Phenomenon in Induced Pluripotent Stem Cells

×

About the authors

E. A. Vaskova

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Meshalkin State Research Institute of Circulation Pathology; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

Author for correspondence.
Email: zakian@bionet.nsc.ru
Россия

A. E. Stekleneva

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Meshalkin State Research Institute of Circulation Pathology; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

Email: zakian@bionet.nsc.ru
Россия

S. P. Medvedev

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Meshalkin State Research Institute of Circulation Pathology; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

Email: zakian@bionet.nsc.ru
Россия

S. M. Zakian

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Meshalkin State Research Institute of Circulation Pathology; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

Email: zakian@bionet.nsc.ru
Россия

References

  1. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., Fry B., Meissner A., Wernig M., Plath K. // Cell. 2006, V.125, №2, P.315-326
  2. Spivakov M., Fisher A.G. // Nat. Rev. Genet. 2007, V.8, №4, P.263-271
  3. Bibikova M., Chudin E., Wu B., Zhou L., Garcia E.W., Liu Y., Shin S., Plaia T.W., Auerbach J.M., Arking D.E. // Genome Res. 2006, V.16, №9, P.1075-1083
  4. Doi A., Park I.H., Wen B., Murakami P., Aryee M.J., Irizarry R., Herb B., Ladd-Acosta c., Rho J., Loewer S. // Nat. Genet. 2009, V.41, №12, P.1350-1353
  5. Maherali N., Ahfeldt T., Rigamonti A., Utikal J., Cowan C., Hochedlinger K. // Cell Stem Cell. 2008, V.3, №3, P.340-345
  6. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. // Cell. 2007, V.131, №5, P.861-872
  7. Takahashi K., Yamanaka S. // Cell. 2006, V.126, №4, P.663-676
  8. Yu J., Vodyanik M.A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J.L., Tian S., Nie J., Jonsdottir G.A., Ruotti V., Stewart R. // Science. 2007, V.318, №5858, P.1917-1920
  9. Zhao X.Y., Li W., Lv Z., Liu L., Tong M., Hai T., Hao J., Guo C.L., Ma Q.W., Wang L. // Nature 2009, V.461, №7260, P.86-90
  10. Pick M., Stelzer Y., Bar-Nur O., Mayshar Y., Eden A., Benvenisty N. // Stem Cells. 2009, V.27, №11, P.2686-2690
  11. Hussein S.M., Batada N.N., Vuoristo S., Ching R.W., Autio R., Narva E., Ng S., Sourour M., Hamalainen R., Olsson C. // Nature 2011, V.471, №7336, P.58-62
  12. Ben-David U., Benvenisty N., Mayshar Y. // Cell Cycle. V.9, №23, P.4603-4604
  13. Martins-Taylor K., Xu R.H. // Stem Cells. 2011, V.30, №1, P.22-27
  14. Sun B., Ito M., Mendjan S., Ito Y., Brons I.G., Murrell A., Vallier L., Ferguson-Smith A.C., Pedersen R.A. // Stem Cells. 2011, V.30, №2, P.161-168
  15. Bar-Nur O., Russ H.A., Efrat S., Benvenisty N. // Cell Stem Cell. 2011, V.9, №1, P.17-23
  16. Kim K., Doi A., Wen B., Ng K., Zhao R., Cahan P., Kim J., Aryee M.J., Ji H., Ehrlich L.I. // Nature 2010, V.467, №7313, P.285-290
  17. Polo J.M., Liu S., Figueroa M.E., Kulalert W., Eminli S., Tan K.Y., Apostolou E., Stadtfeld M., Li Y., Shioda T. // Nat. Biotechnol. 2010, V.28, №8, P.848-855
  18. Adams R.L. // Biochem J. 1990, V.265, №2, P.309-320
  19. Trowbridge J.J., Orkin S.H. // Epigenetics. 2010, V.5, №3, P.189-193
  20. Nishino K., Toyoda M., Yamazaki-Inoue M., Fukawatase Y., Chikazawa E., Sakaguchi H., Akutsu H., Umezawa A. // PLoS Genet. 2011, V.7, №5, P.e1002085
  21. Kim K., Zhao r., Doi A., Ng K., Unternaehrer J., Cahan P., Hongguang H., Loh Y.H., Aryee M.J., Lensch M.W. // Nat. Biotechnol. 2011, V.29, №12, P.1117-1119
  22. Lister R., Pelizzola M., Kida Y.S., Hawkins R.D., Nery J.R., Hon G., Antosiewicz-Bourget J., O’Malley R., Castanon R., Klugman S. // Nature 2011, V.471, №7336, P.68-73
  23. Kaminsky Z.A., Tang T., Wang S.C., Ptak C., Oh G.H., Wong A.H., Feldcamp L.A., Virtanen C., Halfvarson J., Tysk C. // Nat. Genet. 2009, V.41, №2, P.240-245
  24. Shao K., Koch C., Gupta M.K., Lin Q., Lenz M., Laufs S., Denecke B., Schmidt M., Linke M., Hennies H.C. // Molecular Therapy 2012, V.21, №1, P.240-250
  25. Stadtfeld M., Apostolou E., Akutsu H., Fukuda A., Follett P., Natesan S., Kono T., Shioda T., Hochedlinger K. // Nature 2010, V.465, №7295, P.175-181
  26. Da Rocha S.T., Edwards C.A., Ito M., Ogata T., Ferguson-Smith A.C. // Trends Genet. 2008, V.24, №6, P.306-316
  27. Kim M.J., Choi H.W., Jang H.J., Chung H.M., Arauzo-Bravo M.J., Scholer H.R., Tae Do J. // J. Cell Sci. 2012, V.126, №11, P.2516-2524
  28. Stadtfeld M., Apostolou E., Ferrari F., Choi J., Walsh R.M., Chen T., Ooi S.S., Kim S.Y., Bestor T.H., Shioda T. // Nat. Genet. 2012, V.44, №4, P.398-405
  29. Wang T., Chen K., Zeng X., Yang J., Wu Y., Shi X., Qin B., Zeng L., Esteban M.A., Pan G. // Cell Stem Cell. 2011, V.9, №6, P.575-587
  30. Medvedev S.P., Shevchenko A.I., Zakian S.M. // Acta Naturae. 2010, V.2, №2, P.18-28
  31. Cohen D.E., Melton D. // Nat. Rev. Genet. 2011, V.12, №4, P.243-252
  32. Grskovic M., Javaherian A., Strulovici B., Daley G.Q. // Nat. Rev. Drug Discov. 2011, V.10, №12, P.915-929
  33. Medvedev S.P., Grigor’eva E.V., Shevchenko A.I., Malakhova A.A., Dementyeva E.V., Shilov A.A., Pokushalov E.A., Zaidman A.M., Aleksandrova M.A., Plotnikov E.Y. // Stem cells Dev. 2011, V.20, №6, P.1099-1112

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Vaskova E.A., Stekleneva A.E., Medvedev S.P., Zakian S.M.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies