The Proteome of a Healthy Human during Physical Activity under Extreme Conditions

Cover Page

Cite item

Full Text

Abstract

The review examines the new approaches in modern systems biology, in terms of their use for a deeper understanding of the physiological adaptation of a healthy human in extreme environments. Human physiology under extreme conditions of life, or environmental physiology, and systems biology are natural partners. The similarities and differences between the object and methods in systems biology, the OMICs (proteomics, transcriptomics, metabolomics) disciplines, and other related sciences have been studied. The latest data on environmental human physiology obtained using systems biology methods are discussed. The independent achievements of systems biology in studying the adaptation of a healthy human to physical activity, including human presence at high altitude, to the effects of hypoxia and oxidative stress have been noted. A reasonable conclusion is drawn that the application of the methods and approaches used in systems biology to study the molecular pattern of the adaptive mechanisms that develop in the human body during space flight can provide valuable fundamental knowledge and fill the picture of human metabolic pathways.

About the authors

I. M. Larina

SSC RF Institute for Biomedical Problems, Russian Academy of Sciences

Author for correspondence.
Email: irina.larina@gmail.com
Russian Federation

V. A. Ivanisenko

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences

Email: irina.larina@gmail.com
Russian Federation

E. N. Nikolaev

Institute of Biochemical Physics, Russian Academy of Sciences

Email: irina.larina@gmail.com
Russian Federation

A. I. Grigorev

SSC RF Institute for Biomedical Problems, Russian Academy of Sciences

Email: irina.larina@gmail.com
Russian Federation

References

  1. James P. // Quarterly Rev.Biophys. 1997, V.30, №4, P.279-331
  2. Murray R.F., Harper H.W., Granner D.K., Mayes P.A., Rodwell V.W. // Harper’s Illustrated Biochemistry. New York: Lange Medical Books/McGraw-Hill 2006
  3. Hey J., Posch A., Cohen A. // Meth. Mol. Biol. 2008, №424, P.225-239
  4. O’Farrell P.H. // J. Biol. Chem. 1975, V.250, №10, P.4007-4021
  5. Karas M., Bachmann D., Bahr D., Hillenkamp F. // Int. J. Mass Spectrom. Ion 1987, №78, P.53-68
  6. Fenn J.B., Mann M., Meng C.K., Wong S.F., Whitehouse C.M. // Science. 1989, V.246, P.64-71
  7. Bensimon A., Heck A.J.R., Aebersold R. // Annu. Rev. Biochem. 2012, V.81, №1, P.379-405
  8. Alberts B. // Science. 2012, V.337, №6102, P.1583
  9. Bard J. // Cell. 2013, V.2, P.414-431
  10. Lander E.S. // Nature 2011, V.470, №7333, P.187-197
  11. Sverdlov E.D. // Patol. Fiziol. Eksp. Ter. 2010, №3, P.3-23
  12. Sverdlov E.D. // Biochemistry (Mosc.). 2009, V.74, P.939-944
  13. Noble D. // Intersace Focus. 2012, V.2, №1, P.55064
  14. Nagaraj N., Wisniewski J.R., Geiger T., Cox J., Kircher M., Kelso J., Pääbo S., Mann M. // Mol. Syst. Biol. 2011, №7, P.548
  15. Beck M., Schmidt A., Malmstroem J., Claassen M., Ori A., Szymborska A., Herzog F., Rinner O., Ellenberg J., Aebersold R. // Mol. Syst. Biol. 2011, №7, P.549
  16. Munoz J., Low T.Y., Kok Y.J., Chin A., Frese C.K., Ding V., Choo A., Heck A.J. // Mol. Syst. Biol. 2011, №7, P.550
  17. Vidal M., Chan D.W., Gerstein M., Mann M., Omenn G.S., Tagle D., Sechi S. // Clin. Proteomics. 2012, V.9, №1, P.6
  18. Burnette W.N. // Anal. Biochem. 1981, V.112, №2, P.195-203
  19. Zhang Y., Yang C., Wang S., Chen T., Li M., Wang X., Li D., Wang K., Ma J., Wu S. // Liver Int. 2013, V.33, №8, P.1239-1248
  20. Legrain P. // Annual International Congress HUPO-2013, Yokohama, Japan. 12-18 September 2013. Book of Program & Keynote Lectures, 2013
  21. Radivojac P., Clark W.T., Oron T.R., Schnoes A.M., Wittkop T., Sokolov A., Graim K., Funk C., Verspoor K., Ben-Hur A. // Nat. Methods. 2013, V.10, №3, P.221-227
  22. Terentiev A.A., Moldogazieva N.T., Shaitan K.V. // Uspechi Biologicheskoi Chimii. 2009, V.49, P.427-480
  23. Bose B. // Prog. Biophys. Mol. Biol. 2013, V.113, №3, P.358-368
  24. Kitano H. // Science. 2002, V.295, №5560, P.1662-1664
  25. Naylor S., Chen J.Y. // Per. Med. 2010, V.7, №3, P.275-289
  26. Brenner S. // Philos Trans. R. Soc. Lond. B Biol. Sci. 2010, V.365, №1537, P.201-212
  27. Brenner S., Sijnowski T.J. // Science. 2011, V.334, №6056, P.567
  28. Carbo A., Hontecillas R., Kronsteiner B., Viladomiu M., Pedragosa M., Lu P., Philipson C.W., Hoops S., Marathe M., Eubank S. // PLOs Comput. Biol. 2013, V.9, №4, P.e1003027
  29. Chaufan C., Joseph J. // Int. J. Health Serv. 2013, V.43, №2, P.281-303
  30. Cesareni G., Gimona M., Sudol M., Yaffe M. // Modular protein domains. // Weinheim, Germany: Wiley-VCH 2004
  31. Tong A.H., Drees B., Nardelli G., Bader G.D., Branetti B., Castagnoli L., Evangelista M., Ferracuti S., Nelson B., Paoluzi S. // Science. 2002, V.295, №5553, P.21-24
  32. Sommer B., Kormeier B., Demenkov P.S., Arrigo P., Hippe K., Ates Ö., Kochetov A.V., Ivanisenko V.A., Kolchanov N.A., Hofestädt R. // J. Bioinform. Comput. Biol. 2013, V.11, №1, P.1340005
  33. Demenkov P.S., Ivanisenko T.V., Kolchanov N.A., Ivanisenko V.A. // In Silico Biol. 2011-2013, V.11, №3-4, P.149-161
  34. Hood L., Heath J.R., Phelps M.E., Lin B. // Science. 2004, V.306, №5696, P.640-643
  35. Park S., Yang J.S., Jang S.K., Kim S. // J. Proteome Res. 2009, V.8, №7, P.3367-3376
  36. Ivanisenko V.A., Demenkov P.S., Pintus S.S., Ivanisenko T.V., Podkolodny N.L., Ivanisenko L.N., Rozanov A.S., Bryanskaya A.V., Kostrjukova E.S., Levizkiy S.A. // Dokl. Biochem.Biophys. 2012, V.443, P.76-80
  37. Edwards L.M., Thiele I. // Extreme Physiol. Med. 2013, №2, P.1-8
  38. Hargreaves M. // J. Appl. Physiol. 2008, №104, P.1541-1542
  39. Greenhaff P.L., Hargreaves M. // J. Physiol. 2011, №589, P.1031-1036
  40. Carlson R.P., Oshota O.J., Taffs R.L. // Subcell. Biochem. 2012, №64, P.139-157
  41. Thiele I., Palsson B.O. // Nature Protocols 2010, №5, P.93-121
  42. Palsson B. // Systems Biology. Cambridge: Cambridge Univ. Press, 2008. 2008
  43. Kohl P., Crampin E.J., Quinn T.F., Noble D. // Clin. Pharmacol. Ther. 2010, V.88, №1, P.25-33
  44. Hood L., Rowen L., Galas D.J., Aitchison J.D. // Brief Funct. Genomic Proteomic. 2008, V.7, №4, P.239-248
  45. Ideker T., Galitski T., Hood L. // Annu. Rev. Genomics Hum. Genet. 2001, №2, P.343-372
  46. Westerhoff H.V. // Meth. Enzymol. 2011, №500, P.3-11
  47. Shublaq N., Sansom C., Coveney P.V. // Chem. Biol. Drug Des. 2013, V.81, №1, P.5-12
  48. You L. // Cell Biochem.Biophys. 2004, V.40, P.167-184
  49. Shaitan K.V., Turley E.V., Golik D.N., Tereshkina K.V., Levtsova O.V., Fedik I.V., Shaitan A.K., Li A., Kirpichnikov M.P. // Rossiiskii khimicheskii zhurnal. 2006, V.50, P.53-65
  50. Stumpf M.P., Thorne T., de Silva E., Stewart R., An H.J., Lappe M., Wiuf C. // PNAS. 2008, V.105, P.6959-6964
  51. Visvanathan M., Breit M., Pfeifer B., Baumgartner C., Modre-Osprian R., Tilg B. // Meth. Inf. Med. 2007, V.46, P.381-391
  52. Suresh Babu C.V., Joo Song E., Yoo Y.S. // Biochimie. 2006, V.88, №3-4, P.277-283
  53. Conzelmann H., Saez-Rodriguez J., Sauter T., Bullinger E., Allgöwer F., Gilles E.D. // Syst. Biol. (Stevenage). 2004, V.1, №1, P.159-169
  54. Wanjek C. // The NIH Catalyst. 2011, №19, P.1
  55. Duarte N.C., Becker S.A., Jamshidi N., Thiele I., Mo M.L., Vo T.D., Srivas R., Palsson B.Ø. // Proc. Natl. Acad. Sci. USA. 2007, №104, P.1777-1782
  56. Korn R. // Biology and Philosophy. 2005, V.20, №1, P.137-151
  57. Noble D. // Prog.Biophys. Mol. Biol. 2013, V.111, №2-3, P.59-65
  58. Noble D. // Philos Trans. A Math. Phys. Eng. Sci. 2008, V.366, №1878, P.3001-3015
  59. van Regenmortel M.H. // EMBO Rep. 2004, V.5, №11, P.1016-1020
  60. Bordbar A., Palsson B.O. // J. Intern. Med. 2012, №271, P.131-141
  61. Bordbar A., Lewis N.E., Schellenberger J., Palsson B.Ø., Jamshidi N. // Mol. Syst. Biol. 2010, №6, P.422
  62. Gille C., Bolling C., Hoppe A., Bulik S., Hoffmann S., Hübner K., Karlstädt A., Ganeshan R., König M., Rother K. // Mol. Syst. Biol. 2010, №6, P.411
  63. Bordbar A., Feist A.M., Usaite-Black R., Woodcock J., Palsson B.O., Famili I. // BMC Syst. Biol. 2011, №5, P.180
  64. Qu Z., Garfinkel A., Weiss J., Nivala M. // Prog. Biophys. Mol. Biol. 2011, №107, P.21-31
  65. Reed J.L., Patel T.R., Chen K.H., Joyce A.R., Applebee M.K., Herring C.D., Bui O.T., Knight E.M., Fong S.S., Palsson B.O. // Proc. Natl. Acad. Sci. USA. 2006, №103, P.17480-17484
  66. Satish Kumar V., Dasika M.S., Maranas S.D. // BMC Bioinform. 2007, №8, P.212
  67. Kumar V.S., Maranas C.D. // PLoS Comput. Biol. 2009, V.5, P.e1000308
  68. Illig T., Gieger C., Zhai G., Römisch-Margl W., Wang-Sattler R., Prehn C., Altmaier E., Kastenmüller G., Kato B.S., Mewes H.W. // Nat. Genet. 2010, №42, P.137-141
  69. Suhre K., Wallaschofski H., Raffler J., Friedrich N., Haring R., Michael K., Wasner C., Krebs A., Kronenberg F., Chang D. // Nat. Genet. 2011, №43, P.565-569
  70. Edwards L.M., Lawler N.G., Nikolic S.B., Peters J.M., Horne J., Wilson R., Davies N.W., Sharman J.E. // J. Lipid Res. 2012, V.53, №9, P.1979-1986
  71. Orth J.D., Palsson B.O. // Biotechnology and Bioengineering 2010, №107, P.403-412
  72. Rolfsson O., Palsson B.O., Thiele I. // BMC Syst. Biol. 2011, №5, P.155
  73. Kanehisa M., Goto S., Hattori M., Aoki-Kinoshita K.F., Itoh M., Kawashima S., Katayama T., Araki M., Hirakawa M. // Nucleic Acids Research 2006, №34, P.354-357
  74. Jens T., Maillet A., Lang R., Gunga H.C., Johannes B., Gauquelin-Koch G., Kihm E., Larina I., Gharib C., Kirsch K.A. // Am. J. Kidney Dis. 2002, V.40, №3, P.508-516
  75. Grigoriev A.I., Arzamazov G.C., Dorohova B.R., Kozjyrevskaia G.I., Morukov B.V., Natochin J.V., Noskov V.B., Chmelkov V.P. // Guidelines on the use of water and saline water load samples in the assessment of the functional state of human kidneys. Ministry of Health of the Russian Federation, Moscow. USSR. 1979. 1979, P.31
  76. VazquezA. I.O., OltvaiZ.N. I.O. // PLoSOne. 2011, №6, P.e19538
  77. van Beek J.H., Supandi F., Gavai A.K., de Graaf A.A., Binsl T.W., Hettling H. // Philos. Trans. A Math. Phys. Eng. Sci. 2011, №369, P.4295-4315
  78. Zauber H., Mosler S., von Heßberg A., Schulze W.X. // Proteomics. 2012, V.12, №13, P.2221-2235
  79. Martin-Perez M., Fernandez-Borras J., Ibarz A., Millan-Cubillo A., Felip O., de Oliveira E., Blasco J. // J. Proteome Res. 2012, V.6, №11, P.533-547
  80. Pilegaard H., Saltin B., Neufer P.D. // J. Physiol. 2003, V.546(Pt3), P.851-858
  81. Flueck M. // Exp. Physiol. 2010, V.95, №3, P.451-462
  82. Tonevitsky A.G., Maltseva D.V., Abbasi A., Samatov T.R., Sakharov D., Shkurnikov M.U., Lebedev A.E., Galatenko V.V., Grigoriev A.I., Northoff H. // BMC Physiol. 2013, V.13, P.9
  83. Beall C.M., Cavalleri G., Deng L., Elston R.C., Gao Y., Knight J., Li C., Li J.C., Liang Y., McCormack M. // Proc. Natl. Acad. Sci. USA. 2010, №107, P.11459-11464
  84. Yi X., Liang Y., Huerta-Sanchez E., Jin X., Cuo Z.X., Pool J.E., Xu X., Jiang H., Vinckenbosch N., Korneliussen T.S. // Science. 2010, №329, P.75-78
  85. Vigano A., Ripamonti M., De Palma S., Capitanio D., Vasso M., Wait R., Lundby C., Cerretelli P., Gelfi C. // Proteomics. 2008, №8, P.4668-4679
  86. Mainini V., Gianazza E., Chinello C., Bilo G., Revera M., Giuliano A., Caldara G., Lombardi C., Piperno A., Magni F. // Mol. Biosyst. 2012, №8, P.959-966
  87. Ahmad Y., Shukla D., Garg I., Sharma N.K., Saxena S., Malhotra V.K., Bhargava K. // Funct. Integr. Genomics. 2011, №11, P.407-417
  88. Lai X., Nikolov S., Wolkenhauer O., Vera J. // Comput. Biol. Chem. 2009, №3, P.312-324
  89. Turan N., Kalko S., Stincone A., Clarke K., Sabah A., Howlett K., Curnow S.J., Rodriguez D.A., Cascante M., O’Neill L. // PLoS Comput. Biol. 2011, №7, P.e1002129
  90. Stefanini M.O., Qutub A.A., Mac Gabhann F., Popel A.S. // Math. Med. Biol. 2012, №29, P.85-94
  91. Baumann K., Carnicer M., Dragosits M., Graf A.B., Stadlmann J., Jouhten P., Maaheimo H., Gasser B., Albiol J., Mattanovich D. // BMC Syst. Biol. 2010, №4, P.141
  92. Schmierer B., Novak B., Schofield C.J. // BMC Syst. Biol. 2010, №4, P.139
  93. Mac Gabhann F., Qutub A.A., Annex B.H., Popel A.S. // Wiley Interdiscip Rev. Syst. Biol. Med. 2010, №2, P.694-707
  94. Kojima T., Ueda Y., Adati N., Kitamoto A., Sato A., Huang M.C., Noor J., Sameshima H., Ikenoue T. // J. Mol. Neurosci. 2010, №42, P.154-161
  95. Selivanov V.A., Votyakova T.V., Zeak J.A., Trucco M., Roca J., Cascante M. // PLoS Comput. Biol. 2009, №5, P.e1000619
  96. Flueck M. // High Alt. Med. Biol. 2009, V.10, №2, P.183-193
  97. Sharma N.K., Sethy N.K., Bhargava K. // J. Proteomics. 2013, V.21, №79, P.277-298
  98. Ohata Y., Ogata S., Nakanishi K., Kanazawa F., Uenoyama M., Hiroi S., Tominaga S., Toda T., Kawai T. // Histol. Histopathol. 2013, V.28, №7, P.893-902
  99. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. // Int. J. Biochem. Cell Biol. 2007, V.39, №1, P.44-84
  100. Blokhina O., Fagerstedt K.V. // Plant Physiol. Biochem. 2010, V.48, №5, P.359-373
  101. Jones D.P. // Rejuvenation Res. 2006, V.9, №2, P.169-181
  102. Harris C., Shuster D.Z., Roman Gomez R., Sant K.E., Reed M.S., Pohl J., Hansen J.M. // Free Radic. Biol. Med. 2013, №63, P.325-337
  103. Harris C., Hansen J.M. // Methods Mol. Biol. 2012, V.889, P.325-346
  104. Grigorieva A.I. // Orbital station “Mir”. Moscow.: LLC “Anicom” 2002, V.1, P.660
  105. Grigorieva A.I. // Orbital station “Mir”. Moscow.: LLC “Anicom” 2002, V.2, P.623
  106. Grigorieva A.I. // International space station. Moscow.: IBMP RAS 2011
  107. Leach-Huntoon C.S., Grigoriev A.I., Natochin V.Yu. // Am. Astronautical Soc. Publ. SanDiego, California, USA. 1998, V.94, P.220
  108. Stein T.P. // Eur. J. Appl. Physiol. 2013, V.113, №9, P.2171-2181
  109. Larina I.M., Stein T.R., Leskiv M.G., Shluter M.D. // Orbital station “Mir”/ Edited by Grigorieva A.I. Moscow.: LLC “Anicom” 2002, V.2, P.114-121
  110. Ajotto G.B., Himomura Y.S. // J. Nutr. Sci. Vitaminol. 2006, V.52, P.233-247
  111. Gazenko O.G., Grigoriev A.I., Natochin J.V. // Salt and water homeostais and space flight. Moscow.: Nauka, 1986, P.256
  112. Morukov B.V., Noskov V.B., Larina I.M., Natochin Iu.V. // Ros. Fiziol. Zh. Im. I.M. Sechenova. 2003, V.89, №3, P.356-367
  113. Gerzer R., Heer M. // Curr. Pharm. Biotechnol. 2005, V.6, №4, P.299-304
  114. Drummer C., Norsk P., Heer M. // Am. J. Kidney Dis. 2001, V.38, №3, P.684-690
  115. Oganov V.S., Bogomolov V.V., Bakulin A.V., Novikov V.E., Kabitskaia O.E., Murashko L.M., Morgun V.V., Kasparski R.R. // Fiziol Cheloveka. 2010, V.36, №3, P.39-47
  116. Klimovitsky V.Y., Alpatov A.M., Hoban-Higgins T.M., Utekhina E.S., Fuller C.A. // J. Gravit. Physiol. 2000, V.7, P.149
  117. Lakota N.G., Larina I.M. // Human Physiol. 2002, V.28, №3, P.82-92
  118. Robinson E.L., Fuller C.A. // Pflügers Arch. 2000, V.441, S2-3, P.32-38
  119. Fuller P.M., Jones T.A., Jones S.M., Fuller C.A. // Proc. Natl. Acad. Sci. USA. 2002, V.26, №99, P.15723-15728
  120. Larina I.M., Witson P., Smornova T.M., Chen J.M. // Phisiologia cheloveka. 2000, V.26, №4, P.94-100
  121. Baevskiy R.M. // Phisiologia cheloveka. 2002, V.28, №2, P.70-82
  122. FominaG.A. I.O., KotovskayaA.R. I.O., PochuevV.I. I.O., Zhernavkov A.F. // HumanPhysiol. 2008, V.34, №3, P.92-97
  123. Navasiolava N.M., Dignat-George F., Sabatier F., Larina I.M., Demiot C., Fortrat J.O., Gauquelin-Koch G., Kozlovskaya I.B., Custaud M.-A. // Am. J. Physiol. Heart Circ. Physiol. 2010, V.299, №2, P.48-56
  124. Ohira Y., Yoshinaga T., Nomura T., Kawano F., Ishihara A., Nonaka I., Roy R.R., Edgerton V.R. // Adv. Space Res. 2002, V.30, №4, P.777-781
  125. Edgerton V.R., Zhou M.Y., Ohira Y., Klitgaard H., Jiang B., Bell G., Harris B., Saltin B., Gollnick P.D., Roy R.R. // J. Appl. Physiol. 1995, V.78, №5, P.1733-1739
  126. Shenkman B.S., Nemirovskaya T.L., Belozerova I.N., Cheglova I.A., Kozlovskaya I.B. // Report of the Acadamy of Science. 1999, V.367, №2, P.279-281
  127. Tomilovskaya E.S., Berger M., Gerstenbrand F., Kozlovskaya I.B. // J. Gravit. Physiol. 2007, V.14, №1, P.79-80
  128. Kornilova L.N., Naumov I.A., Azarov K.A., Sagalovitch V.N. // Aviat Space Environ. Med. 2012, V.83, №12, P.1123-1134
  129. Baevsky R.M., Baranov V.M., Funtova I.I., Diedrich A., Pashenko A.V., Chernikova A.G., Drescher J., Jordan J., Tank J. // J. Appl. Physiol. 2007, V.103, №1, P.156-161
  130. Baranov V.M., Popova Y.A., Suvorov A.V. // Biomedical research on the Russian segment ISS. // Space biology and medicine. Moscow. 2011, V.2, P.72-92
  131. Grigor’evA.I. I.O., IvanovaS.M. I.O., MorukovB.V. I.O., MaksimovG.V. I.O. // Dokl. Biochem. Biophys. 2008, V.422, P.308-311
  132. Glass D.J. // Trends Mol. Med. 2003, V.9, №8, P.344-350
  133. Jackman R.W., Kandarian S.C. // Am. Physiol. Cell Physiol. 2004, V.287, №4, P.834-843
  134. Ventadour S., Attaix D. // Curr. Opin. Rheumatol. 2006, V.18, №6, P.631-635
  135. Blottner D., Serradj N., Salanova M., Touma C., Palme R., Silva M., Aerts J.M., Berckmans D., Vico L., Liu Y. // J. Comp. Physiol. B. 2009, V.179, №4, P.519-533
  136. Pastushkova L.Kh., Kireev K.S., Kononikhin A.S., Tiys E.S., Popov I.A., Starodubtseva N.L., Dobrokhotov I.V., Ivanisenko V.A., Larina I.M., Kolchanov N.A. // PLoS One 2013, V.8, №8, P.e71652
  137. Kireev K.S. // Kidneys and urinary tract proteins in healthy human urine proteome long-term space flight. // Author’s abstract. candidate of medical sciences. Moscow: SSC RF - IBMP RAS 2013, P.25
  138. Paharukova N.A., Pastushkova L.H., Popova Y.A., Larina I.M. // Bulletin of Experimental Biology and Medicine. 2010, V.148, №2, P.42-45
  139. Pastushkova L.H., Dobrohotov I.V., Veselova O.M., Tiys E.S., Kononihin A.S., Novoselova A.M., Kupe M., Custo M.-A., Larina I.M. // Phisiologia cheloveka. 2014, V.40, №3, P.109-119
  140. Larina I.M., Kolchanov N.A., Dobrohotov I.V., Ivanisenko V.A., Demenkov P.C., Tiys E.S., Valeeva O.A., Pastushkova L.H., Nikolaev E.N. // Phisiologia cheloveka. 2012, V.38, №3, P.107-115
  141. Trifonova O., Larina I., Grigoriev A., Lisitsa A., Moshkovskii S., Archakov A. // ExpertRev. Proteomics. 2010, V.7, №3, P.431-438
  142. Paharukova N.A., Pastushkova L.H., Moshkovskiy S.A., Larina I.M. // Biomedicina. 2011, V.5, №3, P.203-212
  143. Murray A.J. // Genome Med. 2009, №1, P.117
  144. Hood L.E., Omenn G.S., Moritz R.L., Aebersold R., Yamamoto K.R., Amos M., Hunter-Cevera J., Locascio L. // Proteomics. 2012, V.12, №18, P.2773-2783

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Larina I.M., Ivanisenko V.A., Nikolaev E.N., Grigorev A.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies