Mechanisms of Oncolysis by Paramyxovirus Sendai

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Abstract

Some viral strains of the Paramyxoviridae family may be used as anti-tumor agents. Oncolytic paramyxoviruses include attenuated strains of the measles virus, Newcastle disease virus, and Sendai virus. These viral strains, and the Sendai virus in particular, can preferentially induce the death of malignant, rather than normal, cells. The death of cancer cells results from both direct killing by the virus and through virus-induced activation of anticancer immunity. Sialic-acid-containing glycoproteins that are overexpressed in cancer cells serve as receptors for some oncolytic paramyxoviruses and ensure preferential interaction of paramyxoviruses with malignant cells. Frequent genetic defects in interferon and apoptotic response systems that are common to cancer cells ensure better susceptibility of malignant cells to viruses. The Sendai virus as a Paramyxovirus is capable of inducing the formation of syncytia, multinuclear cell structures which promote viral infection spread within a tumor without virus exposure to host neutralizing antibodies. As a result, the Sendai virus can cause mass killing of malignant cells and tumor destruction. Oncolytic paramyxoviruses can also promote the immune-mediated elimination of malignant cells. In particular, they are powerful inducers of interferon and other cytokynes promoting antitumor activity of various cell components of the immune response, such as dendritic and natural killer cells, as well as cytotoxic T lymphocytes. Taken together these mechanisms explain the impressive oncolytic activity of paramyxoviruses that hold promise as future, efficient anticancer therapeutics.

About the authors

O. V. Matveeva

Biopolymer Design

Author for correspondence.
Email: olga.matveeva@gmail.com
United States

G. V. Kochneva

Center of Virology and Biotechnology “Vector”

Email: olga.matveeva@gmail.com
Russian Federation

S. V. Netesov

Novosibirsk State University

Email: olga.matveeva@gmail.com
Russian Federation

S. B. Onikienko

Kirov Military Medical Academy

Email: olga.matveeva@gmail.com
Russian Federation

P. M. Chumakov

Engelhardt Institute of Molecular Biology

Email: olga.matveeva@gmail.com
Russian Federation

References

  1. Svejda J. // Lek. List. 1950, V.5, P.688-689
  2. Arnesen K. // Tidsskr Nor Laegeforen. 1951, V.71, P.232-235
  3. Higgins G.K., Pack G.T. // Bull. Hosp. Joint Dis. 1951, V.12, P.379-382
  4. Loktev V.B., Ivan’kina T., Netesov S.V., Chumakov P.M. // Vestn Ross Akad Med Nauk. 2012, P.42-47
  5. Sviatchenko V.A., Tarasova M.V., Netesov S.V., Chumakov P.M. // Mol Biol (Mosk). 2012, V.46, P.556-569
  6. Kochneva G.V., Sivolobova G.F., Yudina K.V., Babkin I.V., Chumakov P.M., Netesov S.V. // Molecular Genetics, Microbiology and Virology. 2012, V.27, P.8-15
  7. Chumakov P.M., Morozova V.V., Babkin I.V., Baykov I.K., Netesov S.V., Tikunova N.V. // Molecular Biology. 2012, V.46, P.712-725
  8. Kim M., Chung Y.H., Johnston R.N. // J. Microbiol. (Seoul, Korea). 2007, V.45, P.187-192
  9. Lech P.J., Russell S.J. // Expert Rev. Vaccines. 2010, V.9, P.1275-1302
  10. Russell S.J., Peng K.W. // Curr. Top. Microbiol. Immunol. 2009, V.330, P.213-241
  11. Schirrmacher V., Fournier P. // Methods Mol. Biol. 2009, V.542, P.565-605
  12. Keshelava V.V. // Vopr Onkol. 2009, V.55, P.433-435
  13. Fournier P., Schirrmacher V. // Biology. 2013, V.2, P.936-975
  14. Iwata S., Schmidt A.C., Titani K., Suzuki M., Kido H., Gotoh B., Hamaguchi M., Nagai Y. // Virology Journal 1994, V.68, P.3200-3206
  15. Tashiro M., Yokogoshi Y., Tobita K., Seto J.T., Rott R., Kido H. // Virology Journal 1992, V.66, P.7211-7216
  16. Sakai K., Kohri T., Tashiro M., Kishino Y., Kido H. // Europ. Resp. J. 1994, V.7, P.686-692
  17. Sakai K., Kawaguchi Y., Kishino Y., Kido H. // J. Histochem. Cytochem. Official J. Histochem. Soc. 1993, V.41, P.89-93
  18. Nagai Y. // Microbiol. Immunol. 1995, V.39, P.1-9
  19. Scheid A., Choppin P.W. // Virology 1974, V.57, P.475-490
  20. // Infectious diseases of mice and rats. // Nat. Acad. Press, Washington, DC 1991
  21. Slobod K.S., Shenep J.L., Lujan-Zilbermann J., Allison K., Brown B., Scroggs R.A., Portner A., Coleclough C., Hurwitz J.L. // Vaccine. 2004, V.22, P.3182-3186
  22. Kinoh H., Inoue M., Washizawa K., Yamamoto T., Fujikawa S., Tokusumi Y., Iida A., Nagai Y., Hasegawa M. // Gene Ther. 2004, V.11, P.1137-1145
  23. Iwadate Y., Inoue M., Saegusa T., Tokusumi Y., Kinoh H., Hasegawa M., Tagawa M., Yamaura A., Shimada H. // Clin. Cancer Res. 2005, V.11, P.3821-3827
  24. Kinoh H., Inoue M. // Front. Biosci. 2008, V.13, P.2327-2334
  25. Tatsuta K., Tanaka S., Tajiri T., Shibata S., Komaru A., Ueda Y., Inoue M., Hasegawa M., Suita S., Sueishi K., Taguchi T., Yonemitsu Y. // Gene Ther. 2009, V.16, P.240-251
  26. Yonemitsu Y., Ueda Y., Kinoh H., Hasegawa M. // Front. Biosci. 2008, V.13, P.1892-1898
  27. Kurooka M., Kaneda Y. // Cancer Research 2007, V.67, P.227-236
  28. Kawano H., Komaba S., Kanamori T., Kaneda Y. // BMC Med. 2007, V.5, P.28
  29. Kawano H., Komaba S., Yamasaki T., Maeda M., Kimura Y., Maeda A., Kaneda Y. // Cancer Chemother. Pharmacol. 2008, V.61, P.973-978
  30. Fujihara A., Kurooka M., Miki T., Kaneda Y. // Cancer Immunol. Immunotherapy: CII. 2008, V.57, P.73-84
  31. Kawaguchi Y., Miyamoto Y., Inoue T., Kaneda Y. // Int. J. Cancer. 2009, V.124, P.2478-2487
  32. Wheelock E.F., Dingle J.H. // N. Engl. J. Med. 1964, V.271, P.645-651
  33. Senin V., Senina A., Matveeva O. // Russian issued Patent № 2519763. 2014
  34. Senin V., Senina A., Matveeva O. // Patent application PCT/RU2013/001043, WO2014081346 A3. 2014
  35. Lamb R.A., Parks G.D., Knipe D.M., Howley P.M. // Fields Virology / Lippincott. Philadelphia: Williams & Wilkins 2007, P.1449-1496
  36. Bossart K.N., Fusco D.L., Broder C.C. // Adv. Exp. Med. Biol. 2013, V.790, P.95-127
  37. Bitzer M., Lauer U., Baumann C., Spiegel M., Gregor M., Neubert W.J. // Virology Journal 1997, V.71, P.5481-5486
  38. Chawla-Sarkar M., Lindner D.J., Liu Y.F., Williams B.R., Sen G.C., Silverman R.H., Borden E.C. // Apoptosis: Internat. J. Programmed Cell Death. 2003, V.8, P.237-249
  39. Kotredes K.P., Gamero A.M. // J. Interferon Cytokine Res. 2013, V.33, P.162-170
  40. Igney F.H., Krammer P.H. // Nat. Rev. Cancer. 2002, V.2, P.277-288
  41. Rawling J., Cano O., Garcin D., Kolakofsky D., Melero J.A. // Virology Journal 2011, V.85, P.2771-2780
  42. Ebert O., Shinozaki K., Kournioti C., Park M.S., Garcia-Sastre A., Woo S.L. // Cancer Research 2004, V.64, P.3265-3270
  43. Nakamori M., Fu X., Meng F., Jin A., Tao L., Bast R.C., Jr. I.O., Zhang X. // Clin. Cancer Res. 2003, V.9, P.2727-2733
  44. Gainey M.D., Manuse M.J., Parks G.D. // Virology Journal 2008, V.82, P.9369-9380
  45. Altomonte J., Marozin S., Schmid R.M., Ebert O. // Molecular Therapy 2010, V.18, P.275-284
  46. Bateman A., Bullough F., Murphy S., Emiliusen L., Lavillette D., Cosset F.L., Cattaneo R., Russell S.J., Vile R.G. // Cancer Research 2000, V.60, P.1492-1497
  47. Galanis E., Bateman A., Johnson K., Diaz R.M., James C.D., Vile R., Russell S.J. // Hum. Gene Ther. 2001, V.12, P.811-821
  48. Lin E.H., Salon C., Brambilla E., Lavillette D., Szecsi J., Cosset F.L., Coll J.L. // Cancer Gene Ther. 2010, V.17, P.256-265
  49. Pearlstein E., Salk P.L., Yogeeswaran G., Karpatkin S. // Proc. Natl. Acad. Sci. USA. 1980, V.77, P.4336-4339
  50. Yogeeswaran G., Salk P.L. // Science. 1981, V.212, P.1514-1516
  51. Benedetto A., Elia G., Sala A., Belardelli F. // Int. J. Cancer. 1989, V.43, P.126-133
  52. Collard J.G., Schijven J.F., Bikker A., La Riviere G., Bolscher J.G., Roos E. // Cancer Research 1986, V.46, P.3521-3527
  53. Passaniti A., Hart G.W. // J. Biol. Chem. 1988, V.263, P.7591-7603
  54. Bresalier R.S., Rockwell R.W., Dahiya R., Duh Q.Y., Kim Y.S. // Cancer Research 1990, V.50, P.1299-1307
  55. Hsu C.C., Lin T.W., Chang W.W., Wu C.Y., Lo W.H., Wang P.H., Tsai Y.C. // Gynecol. Oncol. 2005, V.96, P.415-422
  56. Chang W.W., Yu C.Y., Lin T.W., Wang P.H., Tsai Y.C. // Biochem. Biophys. Res. Commun. 2006, V.341, P.614-619
  57. Chiang C.H., Wang C.H., Chang H.C., More S.V., Li W.S., Hung W.C. // J. Cell. Physiol. 2010, V.223, P.492-499
  58. Cohen M., Elkabets M., Perlmutter M., Porgador A., Voronov E., Apte R.N., Lichtenstein R.G. // J. Immunol. 2010, V.185, P.5869-5878
  59. Powell L.D., Whiteheart S.W., Hart G.W. // J. Immunol. 1987, V.139, P.262-270
  60. Tyagarajan K., Forte J.G., Townsend R.R. // Glycobiology. 1996, V.6, P.83-93
  61. Drzeniek R., Gauhe A. // Biochem. Biophys. Res. Commun. 1970, V.38, P.651-656
  62. Brostrom M.A., Bruening G., Bankowski R.A. // Virology 1971, V.46, P.856-865
  63. Hua J., Liao M.J., Rashidbaigi A. // J. Leukoc. Biol. 1996, V.60, P.125-128
  64. Nyman T.A., Tolo H., Parkkinen J., Kalkkinen N. // Biochem. J. 1998, V.329, P.295-302
  65. Costas M.A., Mella D., Criscuolo M., Diaz A., Finkielman S., Nahmod V.E., Arzt E. // J. Interferon Res. 1993, V.13, P.407-412
  66. Cantell K., Hirvonen S., Kauppinen H.L., Myllyla G. // Methods Enzymol. 1981, V.78, P.29-38
  67. Suzuki H., Kurooka M., Hiroaki Y., Fujiyoshi Y., Kaneda Y. // FEBS Lett. 2008, V.582, P.1325-1329
  68. Ikeda H., Old L.J., Schreiber R.D. // Cytokine Growth Factor Rev. 2002, V.13, P.95-109
  69. Dunn G.P., Bruce A.T., Sheehan K.C., Shankaran V., Uppaluri R., Bui J.D., Diamond M.S., Koebel C.M., Arthur C., White J.M., Schreiber R.D. // Nat. Immunol. 2005, V.6, P.722-729
  70. Borden E.C., Sen G.C., Uze G., Silverman R.H., Ransohoff R.M., Foster G.R., Stark G.R. // Nat. Rev. Drug Discov. 2007, V.6, P.975-990
  71. Jarahian M., Watzl C., Fournier P., Arnold A., Djandji D., Zahedi S., Cerwenka A., Paschen A., Schirrmacher V., Momburg F. // Virology Journal 2009, V.83, P.8108-8121
  72. Arnon T.I., Lev M., Katz G., Chernobrov Y., Porgador A., Mandelboim O. // Eur. J. Immunol. 2001, V.31, P.2680-2689
  73. Schirrmacher V., Haas C., Bonifer R., Ertel C. // Clin. Cancer Res. 1997, V.3, P.1135-1148
  74. Harada Y., Yonemitsu Y. // Front. Biosci. 2011, V.16, P.2233-2242
  75. Shibata S., Okano S., Yonemitsu Y., Onimaru M., Sata S., Nagata-Takeshita H., Inoue M., Zhu T., Hasegawa M., Moroi Y., Furue M., Sueishi K. // J. Immunol. 2006, V.177, P.3564-3576
  76. Okano S., Yonemitsu Y., Shirabe K., Kakeji Y., Maehara Y., Harada M., Yoshikai Y., Inoue M., Hasegawa M., Sueishi K. // J. Immunol. 2011, V.186, P.1828-1839
  77. Sugiyama M., Kakeji Y., Tsujitani S., Harada Y., Onimaru M., Yoshida K., Tanaka S., Emi Y., Morita M., Morodomi Y. // Mol. Cancer Ther. 2011, V.10, P.540-549
  78. Yoneyama Y., Ueda Y., Akutsu Y., Matsunaga A., Shimada H., Kato T., Kubota-Akizawa M., Okano S., Shibata S., Sueishi K. // Biochem. Biophys. Res. Commun. 2007, V.355, P.129-135
  79. Komaru A., Ueda Y., Furuya A., Tanaka S., Yoshida K., Kato T., Kinoh H., Harada Y., Suzuki H., Inoue M. // J. Immunol. 2009, V.183, P.4211-4219
  80. Kato T., Ueda Y., Kinoh H., Yoneyama Y., Matsunaga A., Komaru A., Harada Y., Suzuki H., Komiya A., Shibata S. // Neoplasia. 2010, V.12, P.906-914
  81. Tanemura A., Kiyohara E., Katayama I., Kaneda Y. // Cancer Gene Ther. 2013, V.20, P.599-605
  82. Nishikawa T., Tung L.Y., Kaneda Y. // Molecular Therapy 2014, V.22, №12, P.2046-2055
  83. Zimmermann M., Armeanu-Ebinger S., Bossow S., Lampe J., Smirnow I., Schenk A., Lange S., Weiss T.S., Neubert W., Lauer U.M., Bitzer M. // PLoS One. 2014, V.9, P.e90508

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