The Impact of ADH1B Alleles and Educational Status on Levels and Modes of Alcohol Consumption in Russian Male Individuals

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Abstract

Alcohol abuse is one of the main reasons behind the low life span in Russia. Both social and genetic factors affect the alcohol consumption level. The genetic factors are alleles of the alcohol dehydrogenase ADH1B and aldehyde dehydrogenaseALDH2 genes. We have typed and found frequencies for the alleles in a cohort of 642 men, ethnic Russians. The individuals of the cohort were asked to complete a questionnaire in the framework of the Izhevsk Family Study (Leon et al., 2007, 2009) regarding the amount of alcohol consumed and on the type of hazardous alcohol consumption (nonbeverage alcohol consumption and the so-called “zapoï” which is a Russian term for a heavy drinking bout lasting for at least 2 days, when an individual is withdrawn from the normal social life). The ADH1B*48His allele was found among heterozygous individuals only (N=68, 10.6% of the cohort). The ALDH2*504Lys allele was also found among heterozygous individuals only (N=2, 0.3%) The effect of ADH1B alleles and the influence of the education level on the amount and type of alcohol consumed had not previously been studied in Russians. We have found that the amount of consumed alcohol is 21.6% lower (1733 g of ethanol per year) for ADH1B*48His allele carriers in the cohort of Russian men. The amount of consumed alcohol was found to be 9.8% lower (793 g of ethanol per year) in the case when individuals had a higher education as compared to those who had a secondary- or elementary school education level in the same cohort. Hence, the protective effect of the genetic factor (ADH1B*48His allele carriage) has proven to be more pronounced than the influence of the social factor (education level) at the individual level in the cohort of Russian men. Both factors have also proven to have a protective effect against hazardous types of alcohol consumption. Zapoï was not scored among individuals of the cohort with ADH1B*48His allele carriage (OR=12.6, P=0.006), as compared to 8.4% of “zapoï” individuals who did not carry the ADH1B*48His allele (genotype Arg/Arg).The percentage of individuals who consume non-beverage alcohol is lower (0.6%) in the subcohort of people with a higher education degree. This percentage is higher (6.0%, OR=10.0, P=0.004) in the subcohort of people without a higher education degree.

About the authors

S. A. Borinskaya

Vavilov Institute of General Genetics, Russian Academy of Sciences; Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: borinskaya@vigg.ru
Russian Federation

A. A. Kim

Vavilov Institute of General Genetics, Russian Academy of Sciences; Moscow Institute of Physics and Technology

Email: borinskaya@vigg.ru
Russian Federation

A. V. Rubanovich

Vavilov Institute of General Genetics, Russian Academy of Sciences

Email: borinskaya@vigg.ru
Russian Federation

N. K. Yankovsky

Vavilov Institute of General Genetics, Russian Academy of Sciences; Moscow Institute of Physics and Technology; Faculty of Biology, Lomonosov Moscow State University

Email: borinskaya@vigg.ru
Russian Federation

References

  1. Nemtsov A.V. // Alcohol mortality in Russia, 1980–90. Moscow. 2001, P.60
  2. Andreev E.M., Kiryanov N.A., Leon D.A., McKee M., Tomkins S., Shkolnikov V.M. // Narkologiya. 2008, №7, P.38-52
  3. Leon D.A., Shkolnikov V.M., McKee M. // Addiction. 2009, V.104, №10, P.1630-1636
  4. Zaridze D., Brennan P., Boreham J., Boroda A., Karpov R., Lazarev A., Konobeevskaya I., Igitov V., Terechova T., Boffetta P. // Lancet. 2009, V.373, №9682, P.2201-2214
  5. Ostrovsky Yu.M., Sadovnik M.N. // Ethanol metabolism pathways and their role in alcohol dependance // Moscow. Results of Science and Technology, VINITI. Toxicology. 1984, №13, P.93-50
  6. Haley Т.J., Berndt W.O. // Handbook of Toxicology. Washington. Hemisphere Publishing Corp. 1987, P.365
  7. Luzhnikov E.A. // Clinical toxicology. Moscow, Medicine. 1994, P.225
  8. Edenberg H.J. // Prog. Nucleic Acid Res. Mol. Biol. 2000, V.64, P.295-341
  9. Jornvall H., Hempel J., Vallee B.L., Bosron W.F., Li T.K. // Proc. Nat. Acad. Sci. USA. 1984, V.81, P.3024-3028
  10. Matsuo K., Wakai K., Hirose K., Ito H., Saito T., Tajima K. // Cancer Epidemiol Biomarkers Prev. 2006, V.15, №5, P.1009-1013
  11. Goedde H.W., Agarwal D.P. // Alcohol Alcohol Suppl. 1987, V.1, P.47-54
  12. Hsu L.C., Bendel R.E., Yoshida A. // Genomics. 1988, V.2, P.57-65
  13. Crabb D.W., Edenberg H.J., Bosron W.F., Li T.K. // J. Clin. Invest. 1989, V.83, P.314-316
  14. Gelernter J., Kranzler H.R. // Genetics of alcohol dependence // Hum. Genet. 2009, V.126, P.91-99
  15. Wall T.L., Horn S.M., Johnson M.L., Smith T.L., Carr L.G. // J. Stud. Alcohol. 2000, V.61, P.13-17
  16. Kim D.J., Choi I.G., Park B.L., Lee B.C., Ham B.J., Yoon S., Bae J.S., Cheong H.S., Shin H.D. // Human Molecular Genetics 2008, V.17, P.854-858
  17. Sherva R., Rice J.P., Neuman R.J., Rochberg N., Saccone N.L., Bierut L.J. // Alcohol Clin Exp Res. 2009, V.33, №5, P.848-857
  18. Macgregor S., Lind P.A., Bucholz K.K., Hansell N.K., Madden P.A., Richter M.M., Montgomery G.W., Martin N.G., Health A.C., Whitfield J.B. // Hum Mol Genet. 2009, V.18, P.580-593
  19. Li H., Borinskaya S., Yoshimura K., Kal’ina N., Marusin A., Stepanov V.A., Qin Z., Khaliq S., Lee M.Y., Yang Y. // Ann Hum Genet. 2009, V.73, P.335-345
  20. Borinskaya S., Kal’ina N., Marusin A., Faskhutdinova G., Morozova I., Kutuev I., Koshechkin V., Khusnutdinova E., Stepanov V., Puzyrev V. // Am J Hum Genet. 2009, V.84, №1, P.89-92
  21. Leon D.A., Saburova L., Tomkins S., Andreev E., Kiryanov N., McKee M., Shkolnikov V.M. // Lancet. 2007, V.369, №9578, P.2001-2009
  22. Tamakoshi A., Hamajima N., Kawase H., Wakai K., Katsuda N., Saito T., Ito H., Hirose K., Takezaki T., Tajima K. // Alcohol Alcohol. 2003, V.38, №5, P.407-410
  23. Abramson J.H. // Epidemiol. Persp.Innov. 2004, V.1, P.6
  24. // http://www.who.int/substance_abuse/publications/global_ alcohol_report/profiles/rus.pdf.
  25. Midanik L.T. // Br J Addict. 1988, V.83, P.1019-1030
  26. Nemtsov A. // Addiction. 2004, V.99, №3, P.386-387
  27. Tomkins S., Saburova L., Kiryanov N., Andreev E., Mc-Kee M., Shkolnikov V., Leon D.A. // Addiction. 2007, V.102, P.544-553
  28. Averbakh L.K., Shamota A.Z. // Problems of Narcology 1992, №2, P.32-37
  29. Nemtsov A.V. // Social and clinical psychiatry 1992, V.2, №4, P.46-53

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Copyright (c) 2013 Borinskaya S.A., Kim A.A., Rubanovich A.V., Yankovsky N.K.

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