The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages

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Abstract


Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles.


The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages

A. L. Rippa

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Author for correspondence.
Email: rippa86@yandex.ru

Russian Federation

E. A. Vorotelyak

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences; M.V. Lomonosov Moscow State University, Biological Department, Division of Cell Biology and Histology

Email: rippa86@yandex.ru

Russian Federation

A. V. Vasiliev

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Email: rippa86@yandex.ru

Russian Federation

V. V. Terskikh

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Email: rippa86@yandex.ru

Russian Federation

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