Acta NaturaeActa Naturae2075-8251Acta Naturae Ltd1056210.32607/20758251-2013-5-4-22-33Research ArticleThe Role of Integrins in the Development and Homeostasis of the Epidermis and Skin AppendagesRippaA. L.rippa86@yandex.ruVorotelyakE. A.rippa86@yandex.ruVasilievA. V.rippa86@yandex.ruTerskikhV. V.rippa86@yandex.ruN.K. Koltzov Institute of Developmental Biology, Russian Academy of SciencesM.V. Lomonosov Moscow State University, Biological Department, Division of Cell Biology and Histology1512201354223317012020Copyright © 2013, Rippa A.L., Vorotelyak E.A., Vasiliev A.V., Terskikh V.V.2013<p>Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles.</p>basement membranehair follicledifferentiationintegrinskeratinocytesmigrationmorphogenesisproliferationstem cellsбазальная мембранаволосяной фолликулдифференцировкаинтегриныкератиноцитымиграцияморфогенезпролиферациястволовые клетки<p>The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages</p>[[1] Hynes R.O. // Cell. 2002, V.110, №6, P.673-687][[2] Barczyk M., Carracedo S., Gullberg D. // Cell Tissue Res. 2010, V.339, №1, P.269-280][[3] Bouvard B., Brakebusch C., Gustafsson E., Aszódi A., Bengtsson T., Berna A., Fässler R. // Circ. Res. 2001, V.89, №3, P.211-223][[4] Bokel C., Brown N.H. // Dev. Cell. 2002, V.3, №3, P.311-321][[5] Stenn K.S., Paus R. // Physiol. Rev. 2001, V.81, №1, P.449-494][[6] Gray J., Dawber R. 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