Use of Transgenic Animals in Biotechnology: Prospects and Problems

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Abstract

During the past two decades, there have been numerous attempts at using animals in order to produce recombinant human proteins and monoclonal antibodies. However, it is only recently that the first two therapeutic agents isolated from the milk of transgenic animals, C1 inhibitor (Ruconest) and antithrombin (ATryn), appeared on the market. This inspires hope that a considerable number of new recombinant proteins created using such technology could become available for practical use in the near future. In this review, the methods applied to produce transgenic animals are described and the advantages and drawbacks related to their use for producing recombinant human proteins and monoclonal antibodies are discussed.

About the authors

O. G. Maksimenko

Institute of Gene Biology of the Russian Academy of Sciences

Email: georgiev_p@mail.ru
Russian Federation

A. V. Deykin

Institute of Gene Biology of the Russian Academy of Sciences

Email: georgiev_p@mail.ru
Russian Federation

Yu. M. Khodarovich

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: georgiev_p@mail.ru
Russian Federation

P. G. Georgiev

Institute of Gene Biology of the Russian Academy of Sciences

Author for correspondence.
Email: georgiev_p@mail.ru
Russian Federation

References

  1. Demain A.L., Vaishnav P. // Biotechnology Advances. 2009. V. 27. P. 297-306.
  2. Durocher Y., Butler M. // Curr. Opin. Biotech. 2009. V. 20. P. 700-707.
  3. Hammer R.E., Brinster R.L., Rosenfeld M.G., Evans R.M., Mayo K.E. // Nature. 1985. V. 315. P. 413-416.
  4. Dyck M.K., Lacroix D., Pothier F., Sirard M.A. // Trends Biotechnol. 2003. V. 21. P. 394-399.
  5. Echelard Y. // Curr. Opin. Biotechnol. 1996. V. 7. P. 536-540.
  6. Houdebine L.-M. // Comp. Immunol. Microbiol. Infect. Dis. 2009. V. 32. P. 107-121.
  7. Redwan el-R.M. // J. Immunoassay Immunochem. 2009. V. 30. P. 262-290.
  8. Rudolph N.S. // TIBTEC H. 1999. V. 17. P. 367-374.
  9. Soler E., Thepot D., Rival-Gervier S., Jolivet G., Houdebine L.-M. // Reprod. Nutr. Dev. 2006. V. 46. P. 579-588.
  10. BIOPHARMA: Biopharmaceutical Products in the US and European Markets. http://biopharma.fmsdb.com/biopharma7. lasso?S=index&DB_test=DD&-nothing
  11. Vàzquez-Salat N., Salter B., Smets G., Houdebine L.-M. // Biotechnology Advances. 2012. . V. 30. № 6. P. 1336-1343.
  12. Kues W.A., Niemann H. // Prev. Vet. Med. 2011. V. 102. P. 146-156.
  13. Goldman I.L., Kadullin S.G., Razin S.V. // Med. Sci. Monit. 2004. V. 10. P. RA274-285.
  14. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., Campbell K.H. // Nature. 1997. V. 385. P. 810-813.
  15. Echelard Y., Williams J.L., Destrempes M.M., Koster J.A., Overton S.A., Pollock D.P., Rapiejko K.T., Behboodi E., Masiello N.C., Gavin W.G., et al. // Transgenic Res. 2009. V. 18. P. 361-376.
  16. Yang P., Wang J., Gong G., Sun X., Zhang R., Du Z., Liu Y., Li R., Ding F., Tang B., et al. // PLoS One. 2008. V. 3. P. e3453.
  17. Whyte J.J., Prather R.S. // Mol. Reprod. Dev. 2011. V. 78. P. 879-891.
  18. Zhang Y., Yang Z., Yang Y., Wang S., Shi L., Xie W., Sun K., Zou K., Wang L., Xiong J., et al. // J. Mol. Cell Biol. 2011. V. 3. P. 132-141.
  19. Honaramooz A., Yang Y. // Vet. Med. Int. 2010. pii: 657860.
  20. Garrels W., Mátés L., Holler S., Dalda A., Taylor U., Petersen B., Niemann H., Izsvák Z., Ivics Z., Kues W.A. // PLoS One. 2011. V. 6. P. e23573.
  21. Shi G., Chen H., Wu X., Zhou Y., Liu Z., Zheng T., Huang P. // Transgenic Res. 2009. V. 18. P. 573-582.
  22. Goldman I.L., Georgieva S.G., Gurskiy Ya.G., Krasnov A.N., Deykin A.V., Popov A.N., Ermolkevich T.G., Budzevich A.I., Chernousov A.D., Sadchikova E.R. // Biochem. Cell Biol. 2012. V. 90. P. 513-519.
  23. van Berkel P.H., Welling M.M., Geerts M., van Veen H.A., Ravensbergen B., Salaheddine M., Pauwels E.K., Pieper F., Nuijens J.H., Nibbering P.H. // Nat. Biotechnol. 2002. V. 20. P. 484-487.
  24. Zhang J., Li L., Cai Y., Xu X., Chen J., Wu Y., Yu H., Yu G., Liu S., Zhang A., et al. // Protein Expression and Purification. 2008. V. 57. P. 127-135.
  25. Platenburg G.J., Kootwijk E.P., Kooiman P.M., Woloshuk S.L., Nuijens J.H., Krimpenfort P.J.A., Pieper F.R., de Boer H.A., Strijker R. // Transgenic Res. 1994. V. 3. P. 99-108.
  26. Deykin A.V., Ermolkevich T.G., Gursky Y.G., Krasnov A.N., Georgieva S.G., Kuznetsov S.L., Derevyanko V.G., Novikova N.I., Murashev A.N., Goldman I.L., et al. // Dokl. Biochem. Biophys. 2009. V. 427. P. 195-198.
  27. Tong J., Wei H., Liu X., Hu W., Bi M., Wang Y., Li Q., Li N. // Transgenic Res. 2011. V. 20. P. 417-419.
  28. Maga E.A., Shoemaker C.F., Rowe J.D., BonDurant R.H., Anderson G.B., Murray J.D. // J. Dairy Sci. 2006. V. 89. P. 518-524.
  29. Maga E.A., Anderson G.B., Huang M.C., Murray J.D. // Transgenic Res. 1994. V. 3. P. 36-42.
  30. Wang J., Yang P., Tang B., Sun X., Zhang R., Guo C., Gong G., Liu Y., Li R., Zhang L., et al. // J. Dairy Sci. 2008. V. 91. P. 4466-4476.
  31. Kabotyanski E.B., Rijnkels M., Freeman-Zadrowski C., Buser A.C., Edwards D.P., Rosen J.M. // J. Biol. Chem. 2009. V. 284. P. 22815-22824.
  32. Choi T., Huang M., Gorman C., Jaenisch R. // Mol. Cell. Biol. 1991. V. 11. P. 3070-3074.
  33. Whitelaw C.B., Archibald A.L., Harris S., McClenaghan M., Simons J.P., Clark A.J. // Transgenic Res. 1991. V. 1. P. 3-13.
  34. Girod P.A., Zahn-Zabal M., Mermod N. // Biotech. Bioeng. 2005. V. 91. P. 1-11.
  35. Girod P.A., Nguyen D.Q., Calabrese D., Puttini S., Grandjean M., Martinet D., Regamey A., Saugy D., Beckmann J.S., Bucher P., et al. // Nat. Methods. 2007. V. 4. P. 747-753.
  36. Benton T., Chen T., McEntee M., Fox B., King D., Crombie R., Thomas T.C., Bebbington C. // Cytotechnology. 2002. V. 38. P. 43-46.
  37. Kwaks T.H.J., Barnett P., Hemrika W., Siersma T., Sewalt R.G., Satijn D.P., Brons J.F., van Blokland R., Kwakman P., Kruckeberg A.L., et al. // Nat. Biotech. 2003. V. 21. P. 553-558.
  38. Kwaks T.H.J., Otte A.P. // Trends Biotechnol. 2006. V. 24. P. 137-142.
  39. Recillas-Targa F., Valadez-Graham V., Farrell C.M. // BioEssays. 2004. V. 26. P. 796-807.
  40. Maksimenko O., Chetverina D., Georgiev P. // Genetika. 2006. T. 42. C. 845-857.
  41. Herold M., Bartkuhn M., Renkawitz R. // Development. 2012. V. 139. P. 1045-1057.
  42. Chung J.H., Bell A.C., Felsenfeld G. // Proc. Natl. Acad. Sci. USA. 1997. V. 94. P. 575-580.
  43. Bell A.C., West A.G., Felsenfeld G. // Cell. 1999. V. 98. P. 387-396.
  44. West A.G., Huang S., Gaszner M., Litt M.D., Felsenfeld G. // Mol. Cell. 2004. V. 16. P. 453-463.
  45. Dickson J., Gowher H., Strogantsev R., Gaszner M., Hair A., Felsenfeld G., West A.G. // PLoS Genetics. 2010. 6:e1000804.
  46. Giles K.E., Gowher H., Ghirlando R., Jin C., Felsenfeld G. // Cold Spring Harbor Symp. Quantitative Biol. 2010. V. 75. P. 1-7.
  47. Giraldo P., Martinez A., Regales L., Lavado A., Garcia-Diaz A., Alonso A., Busturia A., Montoliu L. // Nucl. Acids. Res. 2003. V. 31. P. 6290-6305.
  48. Giraldo P., Rival-Gervier S., Houdebine L.-M., Montoliu L. // Transgenic Res. 2003. V. 12. P. 751-755.
  49. Potts W., Tucker D., Wood H., Martin C. // Biochem. Biophys. Res. Commun. 2000. V. 273. P. 1015-1018.
  50. Rival-Gervier S., Pantano T., Viglietta C., Maeder C., Prince S., Attal J., Jolivet G., Houdebine L.-M. // Transgenic Res. 2003. V. 12. P. 723-730.
  51. Chandler K.J., Chandler R.L., Broeckelmann E.M., Hou Y., Southard-Smith E.M., Mortlock D.P. // Mamm. Genome. 2007. V. 18. P. 693-708.
  52. Tong J., Lillico S.G., Bi M.J., Qing T., Liu X.F., Wang Y.Y., Zheng M., Wang M., Dai Y.P., Bruce C., Whitelaw A., Li N. // Transgenic Res. 2011. V. 20. P. 933-938.
  53. Saidi S., Rival-Gervier S., Daniel-Carlier N., Thépot D., Morgenthaler C., Viglietta C., Prince S., Passet B., Houdebine L.-M., Jolivet G. // Gene. 2007. V. 401. P. 97-107.
  54. Saux A.L., Houdebine L.-M., Jolivet G. // Transgenic Res. 2010. V. 19. P. 923-931.
  55. van Keuren M., Gavrilina G., Filipiak W., Zeidler M., Saunders T. // Transgenic Res. 2009. V. 18. P. 769-785.
  56. Burnouf T. // Vox. Sanguinis. 2011. V. 100. P. 68-83.
  57. Lubon H. // Biotechnol. Annu. Rev. 1998. V. 4. P. 1-54.
  58. Parker M.H., Birck-Wilson E., Allard G., Masiello N., Day M., Murphy K.P., Paragas V., Silver S., Moody M.D. // Protein Expr. Purif. 2004. V. 38. P. 177-183.
  59. Huang Y.J., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., Bilodeau A.S., Bellemare A., Côté M., Herskovits P., et al. // Proc. Natl. Acad. Sci. USA. 2007. V. 104. P. 13603-13608.
  60. Ko J.H., Lee C.S., Kim K.H., Pang M.G., Koo J.S., Fang N., Koo D.B., Oh K.B., Youn W.S., Zheng G.D., et al. // Transgenic Res. 2000. V. 9. P. 215-222.
  61. Lee C.S., Lee D.S., Fang N.Z., Oh K.B., Shin S.T., Lee K.K. // Reprod. Dev. Biol. 2006. V. 30. P. 293-299.
  62. Edmunds T., van Patten S.M., Pollock J., Hanson E., Bernasconi R., Higgins E., Manavalan P., Ziomek C., Meade H., McPherson J.M., et al. // Blood. 1998. V. 91. P. 4561-4571.
  63. Yan J.-B., Wang S., Huang W.-Y., Xiao Y.-P., Ren Z.-R., Huang S.-Z., Zeng Y.-T. // Biochem. Genet. 2006. V. 44. P. 349-360.
  64. Ebert K.M., DiTullio P., Barry C.A., Schindler J.E., Ayres S.L., Smith T.E., Pellerin L.J., Meade H.M., Denman J., Roberts B. // Biotechnology (N.Y.). 1994. V. 12. P. 699-702.
  65. Huang S., Zhang K., Huang Y., Chen M., Li H., Lu D., Lu J., Chen Y., Qiu X., Xue J., et al. // Chin. Sci. Bull. 1998. V. 43. P. 1317-1319.
  66. Salamone D., Baranao L., Santos C., Bussmann L., Artuso J., Werning C., Prync A., Carbonetto C., Dabsys S., Munar C., et al. // J. Biotechnol. 2006. V. 124. P. 469-472.
  67. Serova I.A., Dvoryanchikov G.A., Andreeva L.E., Burkov I.A., Dias L.P., Battulin N.R., Smirnov A.V., Serov O.L. // Transgenic Res. 2012. V. 21. P. 485-498.
  68. Korhonen V.P., Tolvanen M., Hyttinen J.M., Uusi-Oukari M., Sinervirta R., Alhonen L., Jauhiainen M., Jänne O.A., Jänne J. // Eur. J. Biochem. 1997. V. 245. P. 482-489.
  69. Wall R.J., Powell A.M., Paape M.J., Kerr D.E., Bannerman D.D., Pursel V.G., Wells K.D., Talbot N., Hawk H.W. // Nat. Biotechnol. 2005. V. 23. P. 445-451.
  70. Kerr D.E., Plaut K., Bramley A.J., Williamson C.M., Lax A.J., Moore K., Wells K.D., Wall R.J. // Nat. Biotechnol. 2001. V. 19. P. 66-70.
  71. Van Cott K.E., Lubon H., Russell C.G., Butler S.P., Gwazdauska F.C., Knight J., Drohan W.N., Velander W.H. // Transgenic Res. 1997. V. 6. P. 203-212.
  72. van Cott K.E., Butler S.P., Russel C.G., Subbramanian A., Lubon H., Gwazdauskas F.C., Knight J., Drohan W.N., Velander W.H. // Biomol. Engineering. 1999. V. 15. P. 155-160.
  73. Chrenek P., Vasicek D., Makarevich A.V., Jurcik R., Suvegova K., Bauer M., Parkanyi V., Rafay J., Batorova A., Paleyanda R.K. // Transgenic Res. 2005. V. 14. P. 417-428.
  74. Chrenek P., Ryban L., Vetr H., Makarevich A.V., Uhrin P., Paleyanda R.K., Binder B.R. // Transgenic Res. 2007. V. 16. P. 353-361.
  75. Hiripi L., Makovics F., Halter R., Baranyi M., Paul D., Carnwath J.W., Bosze Z., Niemann H. // DNA Cell Biol. 2003. V. 22. P. 41-45.
  76. Baldassarre H., Deslauriers J., Neveu N., Bordignon V. // Transgenic Res. 2011. V. 20. P. 1265-1272.
  77. Toledo J.R., Sánchez O., Seguí R.M., García G., Montañez M., Zamora P.A., Rodríguez M.P., Cremata J.A. // J. Biotechnol. 2006. V. 123. P. 225-235.
  78. Sanchez O., Toledo J.R., Rodriguez M.P., Castro F.O. // J. Biotechnol. 2004. V. 114. P. 89-97.
  79. Han Z.S., Li Q.W., Zhang Z.Y., Xiao B., Gao D.W., Wu S.Y., Li J., Zhao H.W., Jiang Z.L., Hu J.H. // Protein Expr. Purif. 2007. V. 53. P. 225-231.
  80. Gursky Y., Bibilashvili R., Minashkin M., Krasnov A., Deikin A., Ermolkevich T., Popov A., Verbovaya L., Rutkevich N., Shevelev A., et al. // Transgenic Res. 2009. V. 18. P. 747-756.
  81. Gil G.-C., Velander W.H., van Cott K.E. // Glycobiology. 2008. V. 18. P. 526-539.
  82. Koles K., van Berkel P.H., Pieper F.R., Nuijens J.H., Mannesse M.L., Vliegenthart J.F., Kamerling J.P. // Glycobiology. 2004. V. 14. P. 51-64.
  83. Parkera M.H., Birck-Wilsonb E., Allardb G., Masiellob N., Dayb M., Murphya K.P, Paragasa V., Silverb S., Moody M.D. // Protein Exp. Purif. 2004. V. 38. P. 177-183.
  84. Shukla A.A., Thommes J. // Trends Biotech. 2010. V. 28. P. 253-261.
  85. Young M.W., Meade H., Curling J.M., Ziomek C.A., Harvey M. // Res. Immunol. 1998. V. 149. P. 609-610.
  86. Pollock D.P., Kutzko J.P., Birck-Wilson E., Williams J.L., Echelard Y., Meade H.M. // J. Immunol. Meth. 1999. V. 231. P. 147-157.
  87. Simons J.P., McClenaghan M., Clark A.J. // Nature. 1987. V. 328. P. 530-532.
  88. Shamay A., Solinas S., Pursel V.G., McKnight R.A., Alexaner L., Beattie C., Hennighausen L., Wall R.J. // J. Anim. Sci. 1991. V. 69. P. 4552-4562.
  89. Castilla J., Pintado B., Sola I., Sanchez-Morgado J.M., Enjuanes L. // Nat. Biotechnol. 1998. V. 16. P. 349-354.
  90. Limonta J., Pedraza A., Rodriguez A., Freyre F.M., Barral A.M., Castro F.O., Lleonart R., Gracia C.A., Gavilondo J.V., de la Fuente J. // Immunotechnology. 1995. V. 1. P. 107-113.
  91. Sola I., Castilla J., Pintado B., Sanchez-Morgado J.M., Whitelaw C.B., Clark A.J., Enjuanes L. // J. Virol. 1998. V. 72. P. 3762-3772.
  92. Tang B., Yu S., Zheng M., Ding F., Zhao R., Zhao J., Dai Y., Li N. // Transgenic Res. 2008. V. 17. P. 727-732.
  93. Zhang R., Rao M., Li C., Cao J., Meng Q., Zheng M., Wang M., Dai Y., Liang M., Li N. // Transgenic Res. 2009. V. 18. P. 445-453.
  94. Zhang R., Cui D., Wang H., Li C., Yao X., Zhao Y., Liang M., Li N. // Transgenic Res. 2012. doi: 10.1007/s11248-012- 9589-z
  95. Baruah G.L., Belfort G. // Biotech. & Bioenhineering. 2004. V. 87. P. 274-285.
  96. Baruah G.L., Nayak A., Wenkelman E., Belfort G. // Biotech. & Bioenhineering. 2005. V. 93. P. 747-754.
  97. Houdebine L.-M. // Curr. Opin. Biotech. 2002. V. 13. P. 625-629.
  98. Raju T.S., Briggs J.B., Borge S.M., Jones A.J. // Glycobiology. 2000. V. 10. P. 477-486.
  99. Bork K., Horstkorte R., Weidemann W. // J. Pharm. Sci. 2009. V. 98. P. 3499-3508.
  100. Lim Y., Wong N.S.C., Lee Y.Y., Ku S.C.Y., Wong D.C.F. // Biotech. Appl. Biochem. 2010. V. 55. P. 175-189.
  101. Shinkawa T., Nakamura K., Yamane N., Shoji-Hosaka E., Kanda Y., Sakurada M., Uchida K., Anazawa H., Satoh M., Yamasaki M., et al. // J. Biol. Chem. 2003. V. 278. P. 3466-3473.
  102. van Eenennaam A.L., Muir W.M. // Nat. Biotechnol. 2011. V. 29. P. 706-710.
  103. Murray J.D., Maga E.A. // Transgenic Res. 2010. V. 19. P. 357-361.
  104. Maga E.A., Cullor J.S., Smith W., Anderson G.B., Murray J.D. // Foodborne Pathog. Dis. 2006. V. 3. P. 384-392.
  105. Brundige D.R., Maga E.A., Klasing K.C., Murray J.D. // J. Nutr. 2008. V. 138. P. 921-926.
  106. Karatzas C.N., Turner J.D. // J. Dairy Sci. 1997. V. 80. P. 2225-2232.
  107. Kang Y., Jimenez-Flores R., Richardson T. // Basic Life Sci. 1986. V. 37. P. 95-111.
  108. Brophy B., Smolenski G., Wheeler T., Wells D., L’Huillier P., Laible G. // Nat. Biotechnol. 2003. V. 21. P. 157-162.
  109. Wheeler M.B., Bleck G.T., Donovan S.M. // Reprod. Suppl. 2001. V. 58. P. 313-324.
  110. Golovan S.P., Meidinger R.G., Ajakaiye A., Cottrill M., Wiederkehr M.Z., Barney D.J., Plante C., Pollard J.W., Fan M.Z., Hayes M.A., et al. // Nat. Biotechnol. 2001. V. 19. P. 741-745.
  111. Kerr D.E., Wellnitz O. // J. Anim. Sci. 2003. V. 81. P. 38-47.
  112. Weissmann C., Enari M., Klöhn P.C., Rossi D., Flechsig E. // Proc. Natl. Acad. Sci. USA. 2002. V. 99. P. 16378-16383.
  113. Richt J.A., Kasinathan P., Hamir A.N., Castilla J., Sathiyaseelan T., Vargas F. // Nat. Biotechnol. 2007. V. 25. P. 132-138.
  114. 187 Guidance for Industry Regulation of Genetically Engineered Animals Containing Heritable Recombinant DNA Constructs. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Veterinary Medicine (CVM). 2009, 2011.

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