Escort Aptamers: New Tools for the TargetedDelivery of Therapeutics into Cells
- Authors: Davydova AS1, Vorobjeva MA1, Venyaminova AG1
-
Affiliations:
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 3, No 4 (2011)
- Pages: 12-29
- Section: Articles
- Submitted: 17.01.2020
- Published: 15.12.2011
- URL: https://actanaturae.ru/2075-8251/article/view/10652
- DOI: https://doi.org/10.32607/20758251-2011-3-4-12-29
- ID: 10652
Cite item
Abstract
Escort aptamers are DNA or RNA sequences with high affinity to certain cell-surface proteins, which can be used for targeted delivery of various agents into cells of a definite type. The peculiarities of the selection of escort aptamers are discussed in this review. The methods used in selection of escort aptamers via the SELEX technique are considered, including selection against isolated cell-surface proteins, cell fragments, living eukaryotic cells, and bacteria. Particular attention is given to the design and chemical modification of escort aptamers. The different fields of application of escort aptamers are described, including the targeted delivery of siRNAs, nanoparticles, toxins, and photoagents, as well as the identification of specific cell markers and the detection or isolation of cells of a definite type. The potential for the application of escort aptamers in the development of new therapeutic agents and diagnostic systems is also discussed.
Full Text
Escort Aptamers: New Tools for the TargetedDelivery of Therapeutics into Cells×
About the authors
A S Davydova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
M A Vorobjeva
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: maria.vorobjeva@gmail.com
A G Venyaminova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
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