7-Methylguanine Inhibits Colon Cancer Growth in vivo
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1. | Title | Title of document | 7-Methylguanine Inhibits Colon Cancer Growth in vivo |
2. | Creator | Author's name, affiliation, country | K. I. Kirsanov; Blokhin National Medical Research Center of Oncology; RUDN University; Россия |
2. | Creator | Author's name, affiliation, country | T. I. Fetisov; Blokhin National Medical Research Center of Oncology; Россия |
2. | Creator | Author's name, affiliation, country | E. E. Antoshina; Blokhin National Medical Research Center of Oncology; Россия |
2. | Creator | Author's name, affiliation, country | T. G. Gor’kova; Blokhin National Medical Research Center of Oncology; Россия |
2. | Creator | Author's name, affiliation, country | L. S. Trukhanova; Blokhin National Medical Research Center of Oncology; Россия |
2. | Creator | Author's name, affiliation, country | S. I. Shram; National Research Centre “Kurchatov Institute”; Россия |
2. | Creator | Author's name, affiliation, country | I. Yu. Nagaev; National Research Centre “Kurchatov Institute”; Россия |
2. | Creator | Author's name, affiliation, country | Yu. A. Zolotarev; National Research Centre “Kurchatov Institute”; Россия |
2. | Creator | Author's name, affiliation, country | L. Abo Qoura; Blokhin National Medical Research Center of Oncology; RUDN University; Россия |
2. | Creator | Author's name, affiliation, country | V. S. Pokrovsky; Blokhin National Medical Research Center of Oncology; RUDN University; Россия |
2. | Creator | Author's name, affiliation, country | M. G. Yakubovskaya; Blokhin National Medical Research Center of Oncology; Россия |
2. | Creator | Author's name, affiliation, country | V. K. Švedas; Lomonosov Moscow State University; Россия |
2. | Creator | Author's name, affiliation, country | D. K. Nilov; Lomonosov Moscow State University; Россия |
3. | Subject | Discipline(s) | |
3. | Subject | Keyword(s) | 7-methylguanine; inhibitor; poly(ADP-ribose) polymerase 1; tRNA-guanine transglycosylase; colon cancer; BALB/c mice |
4. | Description | Abstract | 7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells. |
5. | Publisher | Organizing agency, location | Acta Naturae Ltd |
6. | Contributor | Sponsor(s) |
Russian Science Foundation (19-74-10072) |
7. | Date | (DD-MM-YYYY) | 21.08.2024 |
8. | Type | Status & genre | Peer-reviewed Article |
8. | Type | Type | Research Article |
9. | Format | File format | |
10. | Identifier | Uniform Resource Identifier | https://actanaturae.ru/2075-8251/article/view/27422 |
10. | Identifier | Digital Object Identifier (DOI) | 10.32607/actanaturae.27422 |
11. | Source | Title; vol., no. (year) | Acta Naturae; Vol 16, No 2 (2024) |
12. | Language | English=en | en |
13. | Relation | Supp. Files |
Fig. 1. Dynamics of colon adenocarcinoma growth in the Akatol model (189KB) doi: 10.32607/20758251-2024-16-2-50-52-131071 Fig. 2. Survival of mice with an inoculated Akatol tumor (animals were excluded from the group when the tumor size reached 4 000 mm3) (143KB) doi: 10.32607/20758251-2024-16-2-50-52-131072 Fig. 3. Dynamics of colon adenocarcinoma growth in a xenograft model (210KB) doi: 10.32607/20758251-2024-16-2-50-52-131073 |
14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
15. | Rights | Copyright and permissions |
Copyright (c) 2024 Kirsanov K.I., Fetisov T.I., Antoshina E.E., Gor’kova T.G., Trukhanova L.S., Shram S.I., Nagaev I.Y., Zolotarev Y.A., Abo Qoura L., Pokrovsky V.S., Yakubovskaya M.G., Švedas V.K., Nilov D.K.![]() This work is licensed under a Creative Commons Attribution 4.0 International License. |