Indexing metadata

7-Methylguanine Inhibits Colon Cancer Growth in vivo

Dublin Core PKP Metadata Items Metadata for this Document
1. Title Title of document 7-Methylguanine Inhibits Colon Cancer Growth in vivo
2. Creator Author's name, affiliation, country K. I. Kirsanov; Blokhin National Medical Research Center of Oncology; RUDN University; Россия
2. Creator Author's name, affiliation, country T. I. Fetisov; Blokhin National Medical Research Center of Oncology; Россия
2. Creator Author's name, affiliation, country E. E. Antoshina; Blokhin National Medical Research Center of Oncology; Россия
2. Creator Author's name, affiliation, country T. G. Gor’kova; Blokhin National Medical Research Center of Oncology; Россия
2. Creator Author's name, affiliation, country L. S. Trukhanova; Blokhin National Medical Research Center of Oncology; Россия
2. Creator Author's name, affiliation, country S. I. Shram; National Research Centre “Kurchatov Institute”; Россия
2. Creator Author's name, affiliation, country I. Yu. Nagaev; National Research Centre “Kurchatov Institute”; Россия
2. Creator Author's name, affiliation, country Yu. A. Zolotarev; National Research Centre “Kurchatov Institute”; Россия
2. Creator Author's name, affiliation, country L. Abo Qoura; Blokhin National Medical Research Center of Oncology; RUDN University; Россия
2. Creator Author's name, affiliation, country V. S. Pokrovsky; Blokhin National Medical Research Center of Oncology; RUDN University; Россия
2. Creator Author's name, affiliation, country M. G. Yakubovskaya; Blokhin National Medical Research Center of Oncology; Россия
2. Creator Author's name, affiliation, country V. K. Švedas; Lomonosov Moscow State University; Россия
2. Creator Author's name, affiliation, country D. K. Nilov; Lomonosov Moscow State University; Россия
3. Subject Discipline(s)
3. Subject Keyword(s) 7-methylguanine; inhibitor; poly(ADP-ribose) polymerase 1; tRNA-guanine transglycosylase; colon cancer; BALB/c mice
4. Description Abstract

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

5. Publisher Organizing agency, location Acta Naturae Ltd
6. Contributor Sponsor(s) Russian Science Foundation (19-74-10072)
7. Date (DD-MM-YYYY) 21.08.2024
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://actanaturae.ru/2075-8251/article/view/27422
10. Identifier Digital Object Identifier (DOI) 10.32607/actanaturae.27422
11. Source Title; vol., no. (year) Acta Naturae; Vol 16, No 2 (2024)
12. Language English=en en
13. Relation Supp. Files Fig. 1. Dynamics of colon adenocarcinoma growth in the Akatol model (189KB) doi: 10.32607/20758251-2024-16-2-50-52-131071
Fig. 2. Survival of mice with an inoculated Akatol tumor (animals were excluded from the group when the tumor size reached 4 000 mm3) (143KB) doi: 10.32607/20758251-2024-16-2-50-52-131072
Fig. 3. Dynamics of colon adenocarcinoma growth in a xenograft model (210KB) doi: 10.32607/20758251-2024-16-2-50-52-131073
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2024 Kirsanov K.I., Fetisov T.I., Antoshina E.E., Gor’kova T.G., Trukhanova L.S., Shram S.I., Nagaev I.Y., Zolotarev Y.A., Abo Qoura L., Pokrovsky V.S., Yakubovskaya M.G., Švedas V.K., Nilov D.K.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.