Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1152210.32607/actanaturae.11522ReviewsОбзорыReview ArticleInactivating Gene Expression with Antisense Modified OligonucleotidesAltmanSidney
United States
sidney.altman@yale.eduAngele-MartinezCarlos
United States
sidney.altman@yale.eduYale University New HavenArizona State UniversityYale University New Haven151120211331011051507202121092021Copyright ©; 2021, Altman S., Angele-Martinez C.Copyright ©; 2021, Altman S., Angele-Martinez C.2021Altman S., Angele-Martinez C.Altman S., Angele-Martinez C.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/11522

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.

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