Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1087110.32607/20758251-2019-11-4-65-72ReviewsОбзорыReview ArticleThe Role of Heritable Tumors in Evolution of Development: a New Theory of Carcino-evo-devoKozlovA P
Russian Federation
contact@biomed.spb.ruVavilov Institute of General Genetics RAS15122019114VOL 11, NO4 (2019)ТОМ 11, №4 (2019)657228012020Copyright ©; 2019, Kozlov A.P.Copyright ©; 2019, Kozlov A.P.2019Kozlov A.P.Kozlov A.P.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10871

The hypothesis of evolution by tumor neofunctionalization (the “main hypothesis”) describes the possible role of hereditary tumors in evolution. The present article examines the relationship of the main hypothesis to other biological theories. As shown in this paper, the main hypothesis does not contradict to the existing biological theories, but fills the lacunas between them and explains some unexplained (or not completely understood) questions. Common features of embryonic development and tumorigenesis are described by several recognized theories. Similarities between normal development and tumorigenesis suggest that tumors could participate in the evolution of ontogenesis and in the origin of new cell types, tissues and organs. A wide spectrum of non-trivial explanations and non-trivial predictions in different fields of biology, suggested by the main hypothesis, is an indication of its fundamental nature and the potential to become a new biological theory, a theory of the role of tumors in evolution of development, or carcino-evo-devo.

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