Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1082010.32607/20758251-2009-1-1-80-83ArticlesСтатьиResearch ArticleLife and Death Decisions in the CD95 System: Main Proand Anti-Apoptotic ModulatorsLife and Death Decisions in the CD95 System: Main Proand Anti-Apoptotic ModulatorsLavrikInna N

Division of Immunogenetics

i.lavrik@dkfz-heidelberg.deKrammerPeter H

Division of Immunogenetics

Tumorimmunology Program German Cancer Research Center1506200911NO1 (2009)№1 (2009)808317012020Copyright ©; 2009, Lavrik I.N., Krammer P.H.Copyright ©; 2009, Lavrik I.N., Krammer P.H.2009Lavrik I.N., Krammer P.H.Lavrik I.N., Krammer P.H.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10820

Apoptosis is common to all multicellular organisms. Apoptosis can be triggered by the extrinsic (death receptor (DR)) or the intrinsic (mitochondrial) death pathways.CD95 (APO-1/Fas) is a prototypic member of the DR family. This review is focused on the mechanisms of CD95 (APO-1/Fas)-mediated apoptosis and the role in the apoptosisof the death effector domain (DED)-containing proteins: pro-apoptotic protein procaspase-8 and anti-apoptotic protein c-FLIP. Gaining insights into these processes willimprove our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and will open new approaches to rational treatment strategies.

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