Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1081710.32607/20758251-2009-1-2-78-80ArticlesСтатьиResearch ArticleRelative Comparison of Catalytic Characteristics of human Foamy Virus and hIV-1 IntegrasesRelative Comparison of Catalytic Characteristics of human Foamy Virus and hIV-1 IntegrasesKnyazhanskayaE SSmolovM AKondrashinaO VGottikhM Bgottikh@libro.belozersky.msu.ruChemistry Department of MSU and MSUDepartment of Bioengineering and Bioinformatics of MSUA. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University1509200912NO2 (2009)№2 (2009)788017012020Copyright ©; 2009, Knyazhanskaya E.S., Smolov M.A., Kondrashina O.V., Gottikh M.B.Copyright ©; 2009, Knyazhanskaya E.S., Smolov M.A., Kondrashina O.V., Gottikh M.B.2009Knyazhanskaya E.S., Smolov M.A., Kondrashina O.V., Gottikh M.B.Knyazhanskaya E.S., Smolov M.A., Kondrashina O.V., Gottikh M.B.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10817

Due to their ability to integrate into the host cell’s genome, retroviruses represent an optimal basis for the creation of gene therapy vectors. The integration reaction is carried out by a viral enzyme integrase: thus, a detailed research of this enzyme is required. In this work, the catalytic properties of human foamy virus integrase were studied. This virus belongs to the Retroviridae family. The dissociation constant was determined, together with the kinetics of integrase catalytic activity. The data obtained were compared to those for the human immunodeficiency virus integrase and a considerable similarity in the activity of the two enzymes was observed.

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