Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1081310.32607/20758251-2009-1-2-61-65ArticlesСтатьиResearch ArticleSelf-Renewalof Stem CellsSelf-Renewalof Stem CellsTerskikhV Vterskikh@bk.ruVorotelyakYe AVasilievA VN.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences1509200912NO2 (2009)№2 (2009)616517012020Copyright ©; 2009, Terskikh V.V., Vorotelyak Y.A., Vasiliev A.V.Copyright ©; 2009, Terskikh V.V., Vorotelyak Y.A., Vasiliev A.V.2009Terskikh V.V., Vorotelyak Y.A., Vasiliev A.V.Terskikh V.V., Vorotelyak Y.A., Vasiliev A.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10813

Asymmetric division is one of the most fundamental characteristics of adult stem cells , which ensures one daughter cell maintains stem cell status and the other daughter cell becomes committed to differentiation. New data emerged recently that allow us to conclude that asymmetric division has another important aspect: it enables self-maintenance of stem cells.

asymmetric divisionstem cellsaging of stem cellsself-renewal of stem cellsaggresomesDrosophila neuroblastsWatt F M., Hogan B.L. // Science. 2000. V. 287. P. 1427–1430.Morrison S.J., Kimble J. // Nature. 2006. V. 441. P. 1068 –1074.Fuchs E. // J. Cell Biol. 2008. V. 180. P. 273–284.Lin H. // J. Cell Biol. 2008. V. 180. P. 257–260.Fuchs E., Tumbar T., Guasch G. // Cell. 2004. V. 116. P. 769–778.Chen D, McKearin D. // Curr. Biol. 2003. V. 13. P. 1786–1791.Horvitz H.R., Herskowitz H. // Cell. 1992. V. 68. P. 237–255.Schierenberg E. // BioEssays. 2001. V. 23. P. 841–847.Wolpert L. // J. Cell Sci. 1988. Suppl. 10. P. 1–9.Knoblich J.A. // Nature Rev. Mol. Cell Biol. 2001. V. 2. P. 11–20.Newton A., Ohta N. // Ann. Rev. Microbiol. 1990. V. 44. P. 689–719.Lawler M.L., Brun Y.V. // Cell. 2006. V. 124. P. 891–893.Kirk D., Kaufman M., Keeling R., Stamer K. // Development. 1991. V. 1 (Suppl.). P.67–82.Strome S. // Int. Rev. Cytol. 1989. V. 114. P. 81–123.Lin H., Schagat T. // Trends in Genet. 1997. V. 13. P. 33–39.Shen Q., Zhong W., Jan Y.N., Temple S. // Development. 2002. V. 129. P. 4843–4853.Roegiers F., Jan Y.N. // Curr. Opin. Cell Biol. 2004. V. 16. P. 195–205.Guo S., Kempus K.J. // Curr. Opin. Genet. Develop. 1996. V. 6. P. 408–415.Bieberich E., MacKinnon S., Silva J., Noggle S., Condie B.G. // J. Cell Biol. 2003. V. 162. P. 469–479.Hatzold J. , Conradt B. // PloS Biol. 2008. V. 6. Issue 4 | e84.Bilder D., Li M., Perriman N. // Science. 2000. V. 289. P. 113–116.Johnson K., Wodarz A. // Nature Cell Biol. 2003. V.5. P. 12–14.Caussinus, E., Gonzalez C. // Nature Genet. 2005. V. 37. P. 1125–1129.Chia W., Somers W.G., Wang H. // J. Cell Biol. 2008. V. 180. P. 267–272.Margolis B., Borg J-P. // J. Cell Sci. 2005. V. 118. P. 5157–5159.Assemat E., Bazellieres E., Pallesi-Pocachard E. et al. // Biochim. Biophys. Acta. 2008. V. 1778. P. 614–30.Ohshiro T., Yagami T., Zhang C., Matsuzaki F. // Nature. 2000. V. 408. P. 593–596.Betschinger, J., Mechtler K., Knoblich J.A. // Nature. 2003. V. 422. P. 326–330.Barres B.A., Siderovski D.P. Knoblich J.A. // Neuron. 2005. V. 48. P. 539–545.Petritsch, C., Tavosanis, G., Turck, C.W. et al. // Dev. Cell. 2003. V. 4. P. 273–281.Wirtz-Peitz F., Nishimura T., Knoblich J.A. // Cell. 2008. V. 135. P. 161–173.Kusch J., Liakopoulos D., Barral Y. // Trends Cell Biol. 2003. V. 13. P. 562–568.Liakopoulos D., Kusch J., Grava S., et al. // Cell. 2003. V. 112. P. 561–574.Kaltschmidt J.A., Davidson C.M., Brown N.H., Brand A.H. // Nature Cell Biol. 2000. V.2. P. 7–12.Haydar T.F., Ang E. Jr., Rakic P. // Proc. Natl. Acad. Sci. USA. 2003. V. 100. P. 2890–2895.Yamashita Y.M., Jones D.L., Fuller M.T. // Science 2003. V. 301. P. 1547–1550.Seery J.P., Watt F.M. // Curr. Biol. 2000. V. 10. P. 1447–1450.Lechler T., Fuchs E. // Nature. 2005. V. 437. P. 275–280.Clayton E., Doupe D.P., Klein A.M. et al. // Nature. 2007. V. 446. P. 185–189.Lamprecht J. // Cell Tissue Kinet. 1990. V. 23. P. 203–216.Huang S., Law P., Francis K. et al. // Blood. 1999. V. 94. P. 2595–2604.Chenn A., McConnell S.K. // Cell. 1995. V. 82. P. 631–641.Shen Q., Zhong W., Jan Y.N., Temple S. // Development. 2002. V. 129. P. 4843–4853.Petersen P.H., Zou K., Hwang J.K. et al. // Nature. 2002. V. 419. P. 929–934.Cayouette M., Raff M., Koster R.W., Fraser S.E. // Nature Neurosci. 2002. V. 5. P. 1265– 1269.Shinin V., Gayraud-Morel B., Gomes D., Tajbakhash S. // Nature Cell Biol. 2006. V. 8. P. 677–687.Wakamatsu Y., Maynard T.M., Jones S.U., Weston J.A. // Neuron 1999. V. 23. P. 71–81.Verdi J.M., Bashirullah A., Goldhawk D.E. et al. // Proc. Natl. Acad. Sci. USA. 1999. V.P. 10472–10476.Yu F., Morin X., Kaushik R. et al. // J. Cell Sci. 2003. V. 116. P. 887–896.Du Q., Stukenberg P.T., Macara I.G. // Nat. Cell Biol. 2001. V. 12. P. 1069–1075.Žigman M., Cayouette M., Charalambous C. et al.// Neuron. 2005. V. 48. P. 539–545.Rando T.A. // Nature. 2006. V. 441. P. 1080–1086.Harrison D.E. // Proc. Natl. Acad. Sci. USA. 1973. V. 70. P. 3184–3188.Ogden D.A., Micklem H.S. // Transplantation. 1976. 22:287–293.Harrison D.E. // J. Exp. Med. 1983. V. 157. P. 1496–1504.Ross E.A., Anderson N., Micklem H.S. // J. Exp. Med. 1982. V. 155. P. 432–444.Iscove N.N., Nawa K. // Curr. Biol. 1997. V. 7. P. 805–808.Morrison S.J., Wandycz A.M.K. Akashi A. et al. // Nat. Med. 1996. V. 2. P. 1011–1016.Liang Y., Van Zant G., Szilvassy S.J. // Blood. 2005. V. 106. P. 1479–1487.Cho R.H., Sieburg H.B., Muller-Sieburg C.E. // Blood. 2008. V. 111. P. 5553–5561.Rossi D.J., Bryder D., Seita J. et al. // Nature. 2007. V. 447. P. 725–729.Geiger H., True J.M., de Haan G., Van Zant G. // Blood. 2001. V. 98. P. 2966–2972.Conboy I.M., Conboy M.J., Wagers A.J. et al. // Nature. 2005. V. 433. P. 760–764.Van Zant G., Scott-Micus K., Thompson B.P. et al. // Exp. Hematol. 1992. V. 20. P.470–475.Jones D.L. // Stem. Cell Rev. 2007. V. 3. P. 192–200.Zeng X. // Stem. Cell Rev. 2007. V. 3. P. 270–279.Stern M.M., Bickenbach J.R. // Aging Cell. 2007. V. 64. P. 439–452.Kopito R.R. // Trends Cell Biol. 2000. V. 10. P. 524–530.Johnston J.A., Ward C.W., Kopito R.R. // J. Cell Biol. 1998. V. 143. P. 1883–1898.Terman A. // Redox Rep. 2001. V. 6. P. 15–26.Bucciantini M., Giannoni E., Chiti F. et al. // Nature. 2002. V. 416. P. 507–511.Moore D.J., Dawson V.L., Dawson T.M. // Molecular Med. 2003. V. 4. P. 95–108.Arrasate M., Mitra S., Schweitzer E.S. et al. // Nature. 2004. V. 431. P. 805–810.Nystrom T. // EMBO J. 2005. V. 24. P. 1311–1317.Rujano M.A., Bosveld F., Salomons F.A. et al. // PloS Biol. 2006. V. 4. Issue12: e417.Rebollo E., Sampaio P., Januschke J. et al. // Developmental Cell. 2007. V. 12. P.467–474.Yamashita Y.M., Jones D.L., Fuller M.T. // Science. 2003. V. 301. P. 1547–1550.Fuentealba L.C., Eivers E., Geissert D. et al. // Proc. Nat. Acad. Sci. USA. 2008. V. 105. P. 7732–7737.