Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1081210.32607/20758251-2009-1-1-51-67ArticlesСтатьиResearch ArticleThe Regulation of Telomerase in OncogenesisThe Regulation of Telomerase in OncogenesisSkvortzovD A

Department of Chemistry

RubzovaM P

Department of Chemistry

ZverevaM E

Department of Chemistry

KiselevF LDonzovaO A

Department of Chemistry

dontsova@genebee.msu.suMoscow State Universitylokhin Oncological Science Centre, Russian Academy of Medical Science1506200911NO1 (2009)№1 (2009)516717012020Copyright ©; 2009, Skvortzov D.A., Rubzova M.P., Zvereva M.E., Kiselev F.L., Donzova O.A.Copyright ©; 2009, Skvortzov D.A., Rubzova M.P., Zvereva M.E., Kiselev F.L., Donzova O.A.2009Skvortzov D.A., Rubzova M.P., Zvereva M.E., Kiselev F.L., Donzova O.A.Skvortzov D.A., Rubzova M.P., Zvereva M.E., Kiselev F.L., Donzova O.A.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10812

Telomerase is a complex ribonucleoprotein that completes the telomeres' ends in eukaryotic cells which shorten due to DnA underreplication. the core enzyme consists of a protein catalytic subunit—telomerase reverse transcriptase (tert)—and telomeric rnA (telomerase rnA (tr)); a small region of this rnA serves as a template for the telomeric repeats synthesis. Apart from rare exceptions, telomerase is not active in the somatic cells and tissues of the human body. However, the activation of telomerase activity in cancer cells was shown for certain in 80–90 % of cases. understanding the mechanism of telomerase functioning and the mechanisms of its regulation could be used in oncodiagnostics. telomerase itself and its regulators could be important targets for anticancer therapy. the activity of telomerase in a cell is affected by proteins with multiple functions, and this influence is not necessarily specific. there are also cases when telomerase regulators act together or when several regulators are organised in the cascade. the aim of this review is to generalize and systemize data about the regulation of telomerase in ontogenesis. Key words: telomerase, telomerase reverse transcriptase, telomerase rnA, regulation, cancer. Abbreviations: 5azadc (5-aza-2'-deoxicitidine), AV (adenoviruses), HBV (Hepatitis B Virus) HIV (Human Immunodeficiency Virus), HPV (Human papillomavirus), eBV (epstein–Barr Virus), np (nucleotide pair), OB-motive (oligonecleotide/oligosaccharide binding motive), rt (reverse transcription), Pcr (polymerase chain reacion), rnAse (ribonuclease), tert (telomerase reverse transcriptase), htert (human tert), mtert (mouse tert), Dn-htert (dominantnegative mutated htert), erβ (estrogen β receptor), HtLV-I (Human t-lymphotropic virus), tr (telomerase rnA), trAP (telomeric repeat Amplification Protocol), PHA (phytohemagglutinin), Hre (Hypoxia response element), neS (nuclear export signal).

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