Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1080410.32607/20758251-2009-1-2-26-32ArticlesСтатьиResearch ArticleInfluenza Virus Neuraminidase: Structure and FunctionInfluenza Virus Neuraminidase: Structure and FunctionShtyryaY AMochalovaL VBovinN Vprofessorbovin@yandex.ruShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS1509200912NO2 (2009)№2 (2009)263217012020Copyright ©; 2009, Shtyrya Y.A., Mochalova L.V., Bovin N.V.Copyright ©; 2009, Shtyrya Y.A., Mochalova L.V., Bovin N.V.2009Shtyrya Y.A., Mochalova L.V., Bovin N.V.Shtyrya Y.A., Mochalova L.V., Bovin N.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10804

The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.

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