Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1080110.32607/20758251-2009-1-2-15-25ArticlesСтатьиResearch ArticleMarine Natural Products: A Way to New DrugsMarine Natural Products: A Way to New DrugsStonikV AStonik@piboc.dvo.ruPacific Institute of Bioorganic Chemistry, Far-eastern Branch of the Russian Academy of Science1509200912NO2 (2009)№2 (2009)152517012020Copyright ©; 2009, Stonik V.A.Copyright ©; 2009, Stonik V.A.2009Stonik V.A.Stonik V.A.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10801

The investigation of marine natural products (low molecular weight bioregulators) is a rapidly developing scientific field at the intersection of biology and chemistry. Investigations aimed at detecting, identifying, and understanding the structure of marine natural products have led to the discovery of 20,000 new substances, including those characterized by an extremely high physiological activity. Some results and prospects of works aimed at creating new drugs on the basis of marine natural products are discussed herein.

marine organismsnatural productsphysiological activitytrabectidinprialthistochromecollagenase KKBergmann W., Feeney R. J. //J. Org. Chem. 1951, 16, 981-987.Bergmann W., Burke D. C. // J. Org. Chem. 1956, 21, 226-228.Bergmann W., Stempien M. F. // J. Org. Chem. 1957, 22, 1575-1577.Newman D. J., Cragg G. M., // J. Nat. Prod., 2004, 67, 1216-1258.Newman D. J., Cragg G. M. // J. Nat. Prod., 2007, 70, 461-477.Rinehart K. L. et al., // J. Org. Chem., 1990, 55, 4512-4515.Wright A. E. et al., // J. Org. Chem., 1990, 55, 4508-4512.Corey E. J., Gin D. Y., Kania R. S. //. J. Am. Chem. Soc., 1996, 118, 9202-9203.Cuevas C, Pérez M, Martín M. J. et al. //Org. Lett., 2000, 2, 993-996.Pommier Y, Kohlhagen G, Bailly C, et al. // Biochemistry, 1996, 35, 13303-13309.Haefner B// Drug Discovery To-Day, 8, 536-544, 2003.Molinski T. F., Dalisay D. S., Lievens S. L., Saludes J. P. // Nat Rev Drug Discov. 2009, 8 January 2009, 8, 69-85.Pettit G. R. et al. // J. Am. Chem. Soc., 1987, 109, 6883-6885.Pettit G.R. et al. // J. Am. Chem. Soc., 1989, 111, 5463-5465.Schoffski P., Thate B., Beutel G., et al. //Ann. Oncol., 2004, 15, 671-679.Talpir R., Benayahu Y., Kashman Y., Panell L, Schleyer M. // Tetrahedron Lett. 1994, 35, 4453-4456.Niu C, Smith D, Zask A, et al. // Bioorg. Med. Chem. Lett. 2004, 14, 4329-4332.Hadaschik B. A., Ettinger S, Sowery R. D., et al. // Int. J. Cancer, 2008, 122, 2368-2376.Gunasekera S. P., Gunasekera M., Longley R. E., Schulte G. K. // J. Org. Chem. 1990, 55, 4912-4915.Harried S. S., Lee C. P., Yang G., Lee T. I., Myles D. C. // J. Org. Chem. 2003, 68, 66466660.Hung D. I., Nerenberg J. B., Schreiber S. I. // J. Am. Chem. Soc., 1993, 115, 12621-12622.Trimurtulu G. et al. // J. Am. Chem. Soc. 1994, 116, 4729-4737.Barow R. A. et al. // J. Am. Chem. Soc. 1995, 117, 2479-2490.Rinehart K. L., Gloer J. B., Cook J. C., Mizsac S. A., Scahill T. A. // J. Am. Chem. Soc.1981, 103, 1857-1859.Gajate C., An F., Mollinedo F. // Clin. Cancer Res. 2003, 9, 1535-1545.Hirata Y., Uemura D// Pure Appl. Chem., 1986, 58, 701-710.Aicher T. D. et al., // J. Am. Chem. Soc. 1992, 114, 3162-3164.Munro M. H., Blunt J. W., Dumdei E. J., et al. // J. Biotechnol., 1990, 70, 15-25.Moore K. S., Wehrli S., Roder H., et al. //Proc. Natl. Acad. Sci, 1993, 90, 1354-1358.Wehrli S. L., Moore K. C., Roder H., Durell S., Zasloff M. // Steroids 1993, 58, 370-378.Sills A. K. Jr, Williams J. I., Tyler B. M., et al. // Cancer Res. 1998, 58, 2784-2792.Ciulla T. A., Criswell M. H., Danis R. P., Williams J. I., McLane M. P., Holroyd K. J. // Retina 2003, 23, 808-814.Gross H., Konig G. H. // Phytochem. Rev., 2006, 5, 115-141.Homann M. T., Scheuer P. J. // J. Am. Chem. Soc., 1993, 115, 5825-5826.Lopez-Macia A., Jimenez J. C., Royo M., Giraet E., Albericio F. // J. Am. Chem. Soc., 2001, 123, 11398-11401.Suárez Y, González L, Cuadrado A, Berciano M, Lafarga M, Muñoz A. // Mol. Camcer Ther. 2003, 2, 863-872.Feling R. H., Buchanan G. O., Mincer T. J., et al. // Angew. Chem. Intl. Ed. 2003, 42, 355357.Chauhan D. L. et al. // Cancer Cell 2005, 8, 407-419.D.J. Newman G. M. Cragg K. M. Snader. // J. Nat. Prod., 2003, 66, 1022-1037.Radchenko O. S., et al. // Tetrahedron Lett. 1997, 38, 3581-3584.Makarieva T. N., Stonik V. A., Dmitrenok A. S., Grebnev B. B., et al. // J. Nat. Prod. 1995, 58, 254-258Lee A. H., Chen J., Liu D., Leung T. Y., Chan A. S., Li T.//C. J. Am. Chem. Soc. 2002, 124, 13972-13973Fedorov S. N., Bode A. M., Stonik V. A., et al. // Pharm. Research, 2004, 21, 2307-2319, 45. Volcho K. P. Use of Natural Compounds in Catalytic Synthesis of Chiral Biologically Active Substances. Abstract of Thesis for Degree of Doctor of Chemical Sciences, Ufa, 2009.Olivera B. M., Gray W. R., Zeikus R., et al. // Science, 1985, 230, 1338-1343.Olivera B. M., Miljanich G. P., Ramachandran J., Adams M.E. // Ann. Rev. Biochem. 1994, 63, 823-867.Chung D., Guar S., Bell J. R., Ramachandran J., Nadasci L. // Int. J. Pept. Protein Res. 1995, 46, 320-325.Wang Y. X., Pettus M., Gao D., Phillips C., Scott Bowersox S. // Pain, 2000, 84, 151-158.Miljanich G. P. //. Curr. Med. Chem. 2004, 11, 3029-3040.Harvey A. L. // Trend Pharmacol. Sci. 2002, 5, 201-203.Roussis V., Wu Z., Fenical W., Strobel S. A., Van Duyne G. D., Clardy J. // J. Org. Chem. 1990, 55, 4916-4922.Potts B. C.M., Faulkner D. J., Jacobs R. C. // J. Nat. Prod. 1992, 55, 1701-1717.Laserwith S. E., Johnson T. W., Corey E. J. // Org. Lett. 2000, 2, 2389-2392.Chow R., et al. // J. Chem. Soc. Perkin Trans I, 2001, 19, 2344-2355.Kocienski P. J., Pontiroli A., Qun L. // J. Chem. Soc. Perkin Trans I, 2001, 19, 2356-2366.Kohl A. C., Kerr R. G. // J. Ind. Microbiol. Biotechnol. 2003, 30, 495-499.Burgoyne D. L., Andersen R. J., Allen T. M. // J. Org. Chem. 1992, 57, 525-528.Takei M., Burgoyne D. L., Andersen R. J. // J. Pharm. Sci. 1994, 83, 1234-1235.Kasserra C. E., Harris P., Stenton G. R., Abraham W., Langlands J. M. // Pulm. Pharmacol. Ther. 2004, 17, 309-318.Shen Y., Burgoyne D. L. // J. Org. Chem. 2002, 67, 3908-3910.De Silva E. D., Scheuer P. J. // Tetrahedron Lett. 1980, 21, 1611-1614.Jacobs R. S., Culver P., Langdon R., O’Brien, T, White S. J. // Tetrahedron, 1985, 41, 981-984Soriente A, De Rosa M. M., Scettri A., et al. // Curr. Med. Chem. 1999, 6, 415-431.Kozlovskaya E. P. et al. Wound-Healing Multifunctional Agent Collagenase KK. Patent of the Russian Federation, 2093166, 1997, Bulletin, Selection. 29, 5.Stonik V. A., Mikhailov V. V., Bulgakov V. P., Zhuravlev Yu. N. // Biotechnol. J., 2007, 2, 818-825.Elyakov G. B., Stonik V.А. // Russian Chem. Bull., 2003, N 1, 1-18.Mayer A. M. S., Rodriguez A. D., Berlinck R. G. S., Hamann M. T. // Comp. Biochem.Physiol. Part C, 2007, 145, 553-581.Gustafson K. R., Oku N., Milanowski D. J. // Curr. Med. Chem. –Anti-Infective Agents, 2004, 3, 233-249.Tzivelka L.-A., Vagias C., Roussis V. // Curr. Topics in Med. Chem. 2003, 3, 1512-1535.Donia M., Hamann M. T. // Lancet Infect Dis., 2003, 3, 338-348.Morimoto M. et al. // Chemotherapy, 1991, 37, 206-211De Clercq E. //Med. Res. Revs, 2000, 20, 323-349Mishchenko N.P., Fedoreev S.А., Bagirova V.L. // Chem. Pharm. Journ., 2003, 37, 49-53.Kem W. R., et al. //Mar. Drugs, 2006, 4, 255-273.Martinez A. // Canc. Opin. Inv. Drugs, 2007, 8, 525-530.Aminin D. L., et al. // Intern. Immunology, 2006, 6, 1070–1082.Belousiv М. V. et al. // Bull. Sib. Med. 2008, № 2, 20-22.Belousiv М. V. et al. // Bull. Sib. Med. 2008, № 3, 9-12.Blunt J. W., Copp B. R., Hu W. P., et al. // Nat. Prod. Rep. 2009, 26, 170-244.Newman, D. J., Hill R. T. // J. Ind. Microbial. Biotechnol., 2006, 33, 539-544.Piel J., Butzke D., Fusetani N., et al. // J. Nat. Prod., 2005, 68, 472-479.Schirmer A., Gadkari R., Reeves C.D., et al. // 2005, 71, 4840-4849.Hildebrand M., Waggoner L. E., Liu H., et al. //Chem. Biol., 2004, 11, 1543-1552.Piel J., Hui D., Wen G., et al. // Proc. Natl. Acad. Sci. USA, 2004, 101, 16222-16227.Venter J. C., Remington K., Heidelberg J. F., et al. // Science, 2004, 304, 66-74.Wijffels R. H. // Trends in Biotechnology, 2007, 26, 26-31.