Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1079310.32607/20758251-2009-1-3-125-135ArticlesСтатьиResearch ArticleStudy of Molecular Mechanisms Involved in the Pathogenesis of Immune-Mediated Inflammatory Diseases, using Psoriasis As a ModelStudy of Molecular Mechanisms Involved in the Pathogenesis of Immune-Mediated Inflammatory Diseases, using Psoriasis As a ModelPiruzianE Seleopiru@vigg.ruSobolevV VAbdeevR MZolotarenkoA DNikolaevA ASarkisovaM KSautinM EIshkinA APiruzyanAn LIlyinaS AKorsunskayaI MRahimovaO YBruskinS AVavilov Institute of General Genetics, Russian Academy of SciencesCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of SciencesMoscow Municipal Hospital № 24, Department of Health1512200913NO3 (2009)№3 (2009)12513517012020Copyright ©; 2009, Piruzian E.S., Sobolev V.V., Abdeev R.M., Zolotarenko A.D., Nikolaev A.A., Sarkisova M.K., Sautin M.E., Ishkin A.A., Piruzyan A.L., Ilyina S.A., Korsunskaya I.M., Rahimova O.Y., Bruskin S.A.Copyright ©; 2009, Piruzian E.S., Sobolev V.V., Abdeev R.M., Zolotarenko A.D., Nikolaev A.A., Sarkisova M.K., Sautin M.E., Ishkin A.A., Piruzyan A.L., Ilyina S.A., Korsunskaya I.M., Rahimova O.Y., Bruskin S.A.2009Piruzian E.S., Sobolev V.V., Abdeev R.M., Zolotarenko A.D., Nikolaev A.A., Sarkisova M.K., Sautin M.E., Ishkin A.A., Piruzyan A.L., Ilyina S.A., Korsunskaya I.M., Rahimova O.Y., Bruskin S.A.Piruzian E.S., Sobolev V.V., Abdeev R.M., Zolotarenko A.D., Nikolaev A.A., Sarkisova M.K., Sautin M.E., Ishkin A.A., Piruzyan A.L., Ilyina S.A., Korsunskaya I.M., Rahimova O.Y., Bruskin S.A.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10793

Psoriasis was used as a model to analyze the pathogenetic pathways of immune-mediated inflammatory diseases, and the results of bioinformatic, molecular-genetic and proteomic studies are provided. Cell mechanisms, common for the pathogenesis of psoriasis, as well as Crohn’s disease, are identified. New approaches for immune-mediated diseases are discussed.

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