Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1077810.32607/20758251-2010-2-3-94-100ArticlesСтатьиResearch ArticleRegulation of Store-Operated Channels by Scaffold Proteins in A431 CellsRegulation of Store-Operated Channels by Scaffold Proteins in A431 CellsShalyginA VRyazantsevaM AGlushankovaL NBezprozvannyI B

Department of Physiology

MozhayevaG N

Department of Physiology

KaznacheyevaE Vevkazn@hotmail.comInstitute of Cytology, Russian Academy of SciencesUniversity of Texas Southwestern Medical Center, Dallas, USA1509201023VOL 2, NO3 (2010)ТОМ 2, №3 (2010)9410017012020Copyright ©; 2010, Shalygin A.V., Ryazantseva M.A., Glushankova L.N., Bezprozvanny I.B., Mozhayeva G.N., Kaznacheyeva E.V.Copyright ©; 2010, Shalygin A.V., Ryazantseva M.A., Glushankova L.N., Bezprozvanny I.B., Mozhayeva G.N., Kaznacheyeva E.V.2010Shalygin A.V., Ryazantseva M.A., Glushankova L.N., Bezprozvanny I.B., Mozhayeva G.N., Kaznacheyeva E.V.Shalygin A.V., Ryazantseva M.A., Glushankova L.N., Bezprozvanny I.B., Mozhayeva G.N., Kaznacheyeva E.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10778

Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that different types of store-operated calcium channels have different sensitivities to Homer proteins.

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