Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1077210.32607/20758251-2010-2-3-78-84ArticlesСтатьиResearch ArticleAdaptive Changes in Mycobacterium avium Gene Expression Profile Following Infection of Genetically Susceptible and Resistant MiceAdaptive Changes in Mycobacterium avium Gene Expression Profile Following Infection of Genetically Susceptible and Resistant MiceIgnatovD VSkvortsovT AMajorovK BAptA SAzhikinaT Ltatazhik@ibch.ruShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of SciencesCentral Research Institute for Tuberculosis, Russian Academy of Medical Sciences1509201023VOL 2, NO3 (2010)ТОМ 2, №3 (2010)788417012020Copyright ©; 2010, Ignatov D.V., Skvortsov T.A., Majorov K.B., Apt A.S., Azhikina T.L.Copyright ©; 2010, Ignatov D.V., Skvortsov T.A., Majorov K.B., Apt A.S., Azhikina T.L.2010Ignatov D.V., Skvortsov T.A., Majorov K.B., Apt A.S., Azhikina T.L.Ignatov D.V., Skvortsov T.A., Majorov K.B., Apt A.S., Azhikina T.L.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10772

We performed a comparative analysis of Mycobacterium avium transcriptomes (strain 724R) in infected mice of two different strains- resistant and susceptible to infection. Sets of mycobacterial genes transcribed in lung tissue were defined, and differentially transcribed genes were revealed. Our results indicate that M. avium genes coding for enzymes of the Krebs cycle, oxidative phosphorylation, NO reduction, fatty acid biosynthesis, replication, translation, and genome modification are expressed at high levels in the lungs of genetically susceptible mice. The expression of genes responsible for cell wall properties, anaerobic nitrate respiration, fatty acid degradation, synthesis of polycyclic fatty acid derivatives, and biosynthesis of mycobactin and other polyketides is increased in the resistant mice. In the resistant host environment, Mycobacterium avium apparently transitions to a latent state caused by the deficiency in divalent cations and characterised by anaerobic respiration, degradation of fatty acids, and modification of cell wall properties.

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