Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1071510.32607/20758251-2010-2-4-52-57ArticlesСтатьиResearch ArticleChromatin Diminution Process Regulates rRNA Gene Copy Number in Freshwater CopepodsChromatin Diminution Process Regulates rRNA Gene Copy Number in Freshwater CopepodsZagoskinM Vzagoskin_mv@mail.ruMarshakT LMukhaD VGrishaninA KVavilov Institute of General Genetics, Russian Academy of SciencesKoltsov Institute of Developmental Biology, Russian Academy of Sciences1512201024VOL 2, NO4 (2010)ТОМ 2, №4 (2010)525717012020Copyright ©; 2010, Zagoskin M.V., Marshak T.L., Mukha D.V., Grishanin A.K.Copyright ©; 2010, Zagoskin M.V., Marshak T.L., Mukha D.V., Grishanin A.K.2010Zagoskin M.V., Marshak T.L., Mukha D.V., Grishanin A.K.Zagoskin M.V., Marshak T.L., Mukha D.V., Grishanin A.K.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10715

The results of quantitative PCR (qPCR) presented in the paper clearly demonstrate that the sixteenfold genome reduction in Cyclops kolensis during chromatin diminution (from 15.3 pg to 0.98 pg) results in a dramatic decrease in ribosomal RNA gene copy numbers in the genome of a somatic cell line by more than two orders of magnitude. The results presented allow for the consideration of the chromatin diminution as a mechanism of rDNA copy number regulation.

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