Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1069610.32607/20758251-2011-3-1-77-84ArticlesСтатьиResearch ArticleA In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kBA In Vitro and In Vivo Study of the Ability of NOD1 Ligands to Activate the Transcriptional Factor NF-kBTukhvatulinA Iamir_tuhvatulin@yahoo.comLogunovD YGitlinI IShmarovM MKudanP VAdzhievaA AMorozA FKostyukovaN NBurdelyaL GNaroditskyB SGintsburgA LGudkovA VGamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical SciencesRoswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, New York, USA1503201131VOL 3, NO1 (2011)ТОМ 3, №1 (2011)778417012020Copyright ©; 2011, Tukhvatulin A.I., Logunov D.Y., Gitlin I.I., Shmarov M.M., Kudan P.V., Adzhieva A.A., Moroz A.F., Kostyukova N.N., Burdelya L.G., Naroditsky B.S., Gintsburg A.L., Gudkov A.V.Copyright ©; 2011, Tukhvatulin A.I., Logunov D.Y., Gitlin I.I., Shmarov M.M., Kudan P.V., Adzhieva A.A., Moroz A.F., Kostyukova N.N., Burdelya L.G., Naroditsky B.S., Gintsburg A.L., Gudkov A.V.2011Tukhvatulin A.I., Logunov D.Y., Gitlin I.I., Shmarov M.M., Kudan P.V., Adzhieva A.A., Moroz A.F., Kostyukova N.N., Burdelya L.G., Naroditsky B.S., Gintsburg A.L., Gudkov A.V.Tukhvatulin A.I., Logunov D.Y., Gitlin I.I., Shmarov M.M., Kudan P.V., Adzhieva A.A., Moroz A.F., Kostyukova N.N., Burdelya L.G., Naroditsky B.S., Gintsburg A.L., Gudkov A.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10696

Pattern-recognition receptors (PRR) play a crucial role in the induction of the defense reactions of the immune system against pathogenic bacterial and viral infections. The activation of PRR by specific, highly conserved pathogen-associated molecular patterns (PAMPs) induces numerous immune reactions related both to innate and adaptive immunity. In addition to the well-studied Toll-like receptors, pathogens can be recognized by the receptors belonging to the other PRR families; including NOD-like receptors (NLR). Stimulation of members of NOD-like receptors (NOD1, 2) and Toll-like receptors results in the activation of the transcriptional factor NF-kB regulating gene expression in numerous molecules implicated in the development of proinflammatory reactions. As opposed to Toll-like receptors, the NF-kB-activating ability of NLRs has not been fully studied. In this work, we examine the ability of one member of the NLR family - NOD1 - to activate the main proinflammatory transcriptional factor NF-kB. We also compare the NF-kB-activating ability of NOD1 ligands of a different structure with TLR4,5 ligands in vitro and in vivo.

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