Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1068210.32607/20758251-2011-3-2-99-102ArticlesСтатьиResearch ArticleRelationship between the Pathogenic Representatives of Periodontal Pockets Microbiocenosis in Patients with Periodontitis with Varying Degrees of SeverityRelationship between the Pathogenic Representatives of Periodontal Pockets Microbiocenosis in Patients with Periodontitis with Varying Degrees of SeverityZorinaO Azorina-cniis@yandex.ruKulakovA ABoriskinaO ARebrikovD VCentral Research Institute of Dentistry and Oral SurgeryVavilov Institute of General Genetics, Russian Academy of SciencesScientific Production Enterprise «DNA Technology», JSC1506201132VOL 3, NO2 (2011)ТОМ 3, №2 (2011)9910217012020Copyright ©; 2011, Zorina O.A., Kulakov A.A., Boriskina O.A., Rebrikov D.V.Copyright ©; 2011, Zorina O.A., Kulakov A.A., Boriskina O.A., Rebrikov D.V.2011Zorina O.A., Kulakov A.A., Boriskina O.A., Rebrikov D.V.Zorina O.A., Kulakov A.A., Boriskina O.A., Rebrikov D.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10682

Periodontitis is a common disease that is considered to be a manifestation of the distortion of the ratio between the normal and conditionally pathogenic microflora of periodontal pockets. In this study, the ratio between the six most important periodontal pathogens and the total microflora of the periodontal pocket in healthy individuals and patients with varying severity of periodontitis was ascertained by quantitative real-time PCR. It was ascertained that the relative content of Porphyromonas gingivalis, Prevotella intermedia, and Tannerella forsythensis (Bacteroides forsythus) persistently develops in the total microflora of the periodontal pocket upon progressing periodontitis; this value is higher than that in the control group by more than two orders of magnitude upon a severe degree of chronic generalized periodontitis.

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