Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1067710.32607/20758251-2011-3-2-56-67ArticlesСтатьиResearch ArticleCharacteristics of Populations of the Russian Federation over the Panel of Fifteen Loci Used for DNA Identification and in Forensic Medical ExaminationCharacteristics of Populations of the Russian Federation over the Panel of Fifteen Loci Used for DNA Identification and in Forensic Medical ExaminationStepanovV Aadim.stepanov@medgenetics.ruBalanovskyO PMelnikovA VLash-ZavadaA YuKhar'kovV NTyazhelovaT VAkhmetovaV LZhukovaO VShneiderYu VShil'nikovaI NBorinskayaS AMarusinA VSpiridonovaM GSimonovaK VKhitrinskayaI YuRadzhabovM ORomanovA GShtygasheva ВO VKoshel'S M

Geography Faculty

BalanovskayaE VRybakovaA VKhusnutdinovaE KPuzyrevV PYankovskyN KInstitute for Medical Genetics, Russian Academy of Medical ScienceGenome Diagnostics, LtdVavilov Institute of General Genetics, Russian Academy of SciencesResearch Centre for Medical Genetics, Russian Academy of SciencesForensic Centre, Ministry of Interior of Russian FederationInstitute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of SciencesDagestan State UniversityKatanov Khakas State UniversityLomonosov Moscow State UniversityInstitute of Biochemistry and Genetics, Ufa Research Centre, Russian Academy of SciencesInstitute for Medical Genetics, Russian Academy of Medical ScienceVavilov Institute of General Genetics, Russian Academy of Sciences1506201132VOL 3, NO2 (2011)ТОМ 3, №2 (2011)566717012020Copyright ©; 2011, Stepanov V.A., Balanovsky O.P., Melnikov A.V., Lash-Zavada A.Y., Khar'kov V.N., Tyazhelova T.V., Akhmetova V.L., Zhukova O.V., Shneider Y.V., Shil'nikova I.N., Borinskaya S.A., Marusin A.V., Spiridonova M.G., Simonova K.V., Khitrinskaya I.Y., Radzhabov M.O., Romanov A.G., Shtygasheva В O.V., Koshel' S.M., Balanovskaya E.V., Rybakova A.V., Khusnutdinova E.K., Puzyrev V.P., Yankovsky N.K.Copyright ©; 2011, Stepanov V.A., Balanovsky O.P., Melnikov A.V., Lash-Zavada A.Y., Khar'kov V.N., Tyazhelova T.V., Akhmetova V.L., Zhukova O.V., Shneider Y.V., Shil'nikova I.N., Borinskaya S.A., Marusin A.V., Spiridonova M.G., Simonova K.V., Khitrinskaya I.Y., Radzhabov M.O., Romanov A.G., Shtygasheva В O.V., Koshel' S.M., Balanovskaya E.V., Rybakova A.V., Khusnutdinova E.K., Puzyrev V.P., Yankovsky N.K.2011Stepanov V.A., Balanovsky O.P., Melnikov A.V., Lash-Zavada A.Y., Khar'kov V.N., Tyazhelova T.V., Akhmetova V.L., Zhukova O.V., Shneider Y.V., Shil'nikova I.N., Borinskaya S.A., Marusin A.V., Spiridonova M.G., Simonova K.V., Khitrinskaya I.Y., Radzhabov M.O., Romanov A.G., Shtygasheva В O.V., Koshel' S.M., Balanovskaya E.V., Rybakova A.V., Khusnutdinova E.K., Puzyrev V.P., Yankovsky N.K.Stepanov V.A., Balanovsky O.P., Melnikov A.V., Lash-Zavada A.Y., Khar'kov V.N., Tyazhelova T.V., Akhmetova V.L., Zhukova O.V., Shneider Y.V., Shil'nikova I.N., Borinskaya S.A., Marusin A.V., Spiridonova M.G., Simonova K.V., Khitrinskaya I.Y., Radzhabov M.O., Romanov A.G., Shtygasheva В O.V., Koshel' S.M., Balanovskaya E.V., Rybakova A.V., Khusnutdinova E.K., Puzyrev V.P., Yankovsky N.K.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10677

Seventeen population groups within the Russian Federation were characterized for the first time using a panel of 15 genetic markers that are used for DNA identification and in forensic medical examinations. The degree of polymorphism and population diversity of microsatellite loci within the Power Plex system (Promega) in Russian populations; the distribution of alleles and genotypes within the populations of six cities and 11 ethnic groups of the Russian Federation; the levels of intra- and interpopulation genetic differentiation of population; genetic relations between populations; and the identification and forensic medical characteristics of the system of markers under study were determined. Significant differences were revealed between the Russian populations and the U.S. reference base that was used recently in the forensic medical examination of the RF. A database of the allelic frequencies of 15 microsatellite loci that are used for DNA identification and forensic medical examination was created; the database has the potential of becoming the reference for performing forensic medical examinations in Russia. The spatial organization of genetic diversity over the panel of the STR markers that are used for DNA identification was revealed. It represents the general regularities of geographical clusterization of human populations over various types of genetic markers. The necessity to take into account a population’s genetic structure during forensic medical examinations and DNA identification of criminal suspects was substantiated.

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