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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Acta Naturae</journal-id><journal-title-group><journal-title xml:lang="en">Acta Naturae</journal-title><trans-title-group xml:lang="ru"><trans-title>Acta Naturae</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-8251</issn><publisher><publisher-name xml:lang="en">Acta Naturae Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10654</article-id><article-id pub-id-type="doi">10.32607/20758251-2011-3-4-38-54</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">NAD+-dependent Formate Dehydrogenase from Plants</article-title><trans-title-group xml:lang="ru"><trans-title>NAD+-dependent Formate Dehydrogenase from Plants</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Alekseeva</surname><given-names>A A</given-names></name><bio xml:lang="en"><p>Chemistry Department</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name><surname>Savin</surname><given-names>S S</given-names></name><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name><surname>Tishkov</surname><given-names>V I</given-names></name><bio xml:lang="en"><p>Chemistry Department</p></bio><email>vitishkov@gmail.com</email><xref ref-type="aff" rid="aff6"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Innovations and High Technologies MSU Ltd</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Bach Institute of Biochemistry, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><aff id="aff4"><institution>Innovations and High Technologies MSU Ltd</institution></aff><aff id="aff5"><institution>Bach Institute of Biochemistry, Russian Academy of Sciences</institution></aff><aff id="aff6"><institution>Lomonosov Moscow State University</institution></aff><pub-date date-type="pub" iso-8601-date="2011-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2011</year></pub-date><volume>3</volume><issue>4</issue><issue-title xml:lang="en">VOL 3, NO4 (2011)</issue-title><issue-title xml:lang="ru">ТОМ 3, №4 (2011)</issue-title><fpage>38</fpage><lpage>54</lpage><history><date date-type="received" iso-8601-date="2020-01-17"><day>17</day><month>01</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Alekseeva A.A., Savin S.S., Tishkov V.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, Alekseeva A.A., Savin S.S., Tishkov V.I.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Alekseeva A.A., Savin S.S., Tishkov V.I.</copyright-holder><copyright-holder xml:lang="ru">Alekseeva A.A., Savin S.S., Tishkov V.I.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://actanaturae.ru/2075-8251/article/view/10654">https://actanaturae.ru/2075-8251/article/view/10654</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p>NAD +-dependent formate dehydrogenase (FDH, EC 1.2.1.2) widely occurs in nature. FDH consists of two identical subunits and contains neither prosthetic groups nor metal ions. This type of FDH was found in different microorganisms (including pathogenic ones), such as bacteria, yeasts, fungi, and plants. As opposed to microbiological FDHs functioning in cytoplasm, plant FDHs localize in mitochondria. Formate dehydrogenase activity was first discovered as early as in 1921 in plant; however, until the past decade FDHs from plants had been considerably less studied than the enzymes from microorganisms. This review summarizes the recent results on studying the physiological role, properties, structure, and protein engineering of plant formate dehydrogenases.</p></trans-abstract><kwd-group xml:lang="en"><kwd>plant formate dehydrogenase</kwd><kwd>physiological role</kwd><kwd>properties</kwd><kwd>structure</kwd><kwd>expression</kwd><kwd>Escherichia coli</kwd><kwd>protein engineering</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rodionov Yu.V. // Uspekhi microbiologii. 1982. V. 16. P.104-138 (rus).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ferry J.G. // FEMS Microbiol. Rev. 1990. V. 7. P. 377-382.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Vinals C., Depiereux E., Feytmans E. // Biochem. Biophys. Res. Commun 1993. V. 192. P. 182-188.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Tishkov V.I., Galkin A.G., Egorov A.M. // Biochimie. 1989. V. 71. № 4. 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