Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1065210.32607/20758251-2011-3-4-12-29ArticlesСтатьиReview ArticleEscort Aptamers: New Tools for the TargetedDelivery of Therapeutics into CellsEscort Aptamers: New Tools for the TargetedDelivery of Therapeutics into CellsDavydovaA SVorobjevaM Amaria.vorobjeva@gmail.comVenyaminovaA GInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences1512201134VOL 3, NO4 (2011)ТОМ 3, №4 (2011)122917012020Copyright ©; 2011, Davydova A.S., Vorobjeva M.A., Venyaminova A.G.Copyright ©; 2011, Davydova A.S., Vorobjeva M.A., Venyaminova A.G.2011Davydova A.S., Vorobjeva M.A., Venyaminova A.G.Davydova A.S., Vorobjeva M.A., Venyaminova A.G.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10652

Escort aptamers are DNA or RNA sequences with high affinity to certain cell-surface proteins, which can be used for targeted delivery of various agents into cells of a definite type. The peculiarities of the selection of escort aptamers are discussed in this review. The methods used in selection of escort aptamers via the SELEX technique are considered, including selection against isolated cell-surface proteins, cell fragments, living eukaryotic cells, and bacteria. Particular attention is given to the design and chemical modification of escort aptamers. The different fields of application of escort aptamers are described, including the targeted delivery of siRNAs, nanoparticles, toxins, and photoagents, as well as the identification of specific cell markers and the detection or isolation of cells of a definite type. The potential for the application of escort aptamers in the development of new therapeutic agents and diagnostic systems is also discussed.

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