Acta NaturaeActa NaturaeActa Naturae2075-8251Acta Naturae Ltd1060710.32607/20758251-2013-5-1-85-89Research ArticlesЭкспериментальные статьиResearch ArticleOverexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated CellsOverexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated CellsShevchukZ.
Sweden
Elena.Kashuba@ki.seYurchenkoM. Y.
Ukraine
Elena.Kashuba@ki.seDarekarS. D.
Sweden
Elena.Kashuba@ki.seHolodnuka-KholodnyukI.
Latvia
Elena.Kashuba@ki.seKashubaV. I.
Ukraine
Elena.Kashuba@ki.seKashubaE. V.
Sweden
Elena.Kashuba@ki.seDepartment of Microbiology, Tumor and Cell Biology (MTC), Karolinska InstitutetKavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NASUKirchenstein Institute of Microbiology and Virology, Riga Stradins UniversityInstitute of Molecular Biology and Genetics of NASUKavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NASU1503201351VOL 5, NO1 (2013)ТОМ 5, №1 (2013)858917012020Copyright ©; 2013, Shevchuk Z., Yurchenko M.Y., Darekar S.D., Holodnuka-Kholodnyuk I., Kashuba V.I., Kashuba E.V.Copyright ©; 2013, Shevchuk Z., Yurchenko M.Y., Darekar S.D., Holodnuka-Kholodnyuk I., Kashuba V.I., Kashuba E.V.2013Shevchuk Z., Yurchenko M.Y., Darekar S.D., Holodnuka-Kholodnyuk I., Kashuba V.I., Kashuba E.V.Shevchuk Z., Yurchenko M.Y., Darekar S.D., Holodnuka-Kholodnyuk I., Kashuba V.I., Kashuba E.V.https://creativecommons.org/licenses/by/4.0https://actanaturae.ru/2075-8251/article/view/10607

Human mitochondrial ribosomal protein MRPS18-2 (S18-2) is encoded by a cellular gene that is located on the human chromosome 6p21.3. We discovered that overexpression of the S18-2 protein led to immortalization and de-differentiation of primary rat embryonic fibroblasts. Cells showed anchorage-independent growth pattern. Moreover, pathways characteristic for rapidly proliferating cells were upregulated then. It is possible that the S18-2 overexpression induced disturbance in cell cycle regulation. We found that overexpression of S18-2 protein in human cancer cell lines led to an appearance of multinucleated cells in the selected clones.

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