Acta NaturaeActa Naturae2075-8251Acta Naturae Ltd1053510.32607/20758251-2014-6-3-52-65Research ArticleStructural Features of the Interaction between Human 8-Oxoguanine DNA Glycosylase hOGG1 and DNAKovalV. V.fedorova@niboch.nsc.ruKnorreD. G.fedorova@niboch.nsc.ruFedorovaO. S.fedorova@niboch.nsc.ruInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesNovosibirsk State University1509201463526517012020Copyright © 2014, Koval V.V., Knorre D.G., Fedorova O.S.2014<p>The purpose of the present review is to summarize the data related with the structural features of interaction between the human repair enzyme 8-oxoguanine DNA glycosylase (hOGG1) and DNA. The review covers the questions concerning the role of individual amino acids of hOGG1 in the specific recognition of the oxidized DNA bases, formation of the enzyme-substrate complex, and excision of the lesion bases from DNA. Attention is also focused upon conformational changes in the enzyme active site and disruption of enzyme activity as a result of amino acid mutations. The mechanism of damaged bases release from DNA induced by hOGG1 is discussed in the context of structural dynamics.</p>protein-nucleic acid recognitionhuman 8-oxoguanine DNA glycosylaserepair enzymesloss-offunction mutantsstructural analysis of hOGG1белково-нуклеиновое узнавание8-оксогуанин-ДНК-гликозилаза человекаферменты
репарациифункциональные мутантыструктурный анализ hOGG1[[1] Wallace S.S. // Free Radic. Biol. Med. 2002, V.33, №1, P.1-14][[2] Marnett L.J. // Carcinogenesis. 2000, V.21, №3, P.361-370][[3] Dizdaroglu M., Jaruga P., Birincioglu M., Rodriguez H. // Free Radic. Biol. Med. 2002, V.32, №11, P.1102-1115][[4] Boiteux S., Guillet M. // DNA Repair (Amst.). 2004, V.3, №1, P.1-12][[5] Cooke M.S., Evans M.D., Dizdaroglu M., Lunec J. // FASEB J. 2003, V.17, №10, P.1195-1214][[6] Evans M.D., Dizdaroglu M., Cooke M.S. // Mutat. Res. 2004, V.567, №1, P.1-61][[7] Xie Y., Yang H., Cunanan C., Okamoto K., Shibata D., Pan J., Barnes D.E., Lindahl T., McIlhatton M., Fishel R., Miller J.H. // Cancer Research 2004, V.64, №9, P.3096-3102][[8] Wan J., Bae M.A., Song B.J. // Exp. Mol. Med. 2004, V.36, №1, P.71-77][[9] Gu Y., Desai T., Gutierrez P.L., Lu A.L. // Med. Sci. Monit. 2001, V.7, №5, P.861-868][[10] Raha S., Robinson B.H. // Trends Biochem. Sci. 2000, V.25, №10, P.502-508][[11] Halliwell B., Gutteridge J.M.C. // Free Radicals in Biology and Medicine. Oxford: Oxford Univ. Press, 2002][[12] Jezek P., Hlavata L. // Int. J. Biochem. Cell. Biol. 2005, V.37, №12, P.2478-2503][[13] Bernards A.S., Miller J.K., Bao K.K., Wong I. // J. Biol. Chem. 2002, V.277, №23, P.20960-20964][[14] Kasai H., Nishimura S. // Nucleic Acids Res. 1984, V.12, №4, P.2137-2145][[15] Shibutani S., Takeshita M., Grollman A.P. // Nature 1991, V.349, №6308, P.431-434][[16] Grollman A.P., Moriya M. // Trends Genet. 1993, V.9, №7, P.246-249][[17] Michaels M.L., Miller J.H. // Journal of Bacteriology 1992, V.174, №20, P.6321-6325][[18] Fowler R.G., White S.J., Koyama C., Moore S.C., Dunn R.L., Schaaper R.M. // DNA Repair (Amst.). 2003, V.2, №2, P.159-173][[19] Sakumi K., Furuichi M., Tsuzuki T., Kakuma T., Kawabata S., Maki H., Sekiguchi M. // J. Biol. Chem. 1993, V.268, №31, P.23524-23530][[20] Slupska M.M., Baikalov C., Luther W.M., Chiang J.-H., Wei Y.-F., Miller J.H. // Journal of Bacteriology 1996, V.178, №13, P.3885-3892][[21] Lu R., Nash H.M., Verdine G.L. // Curr. Biol. 1997, V.7, №6, P.397-407][[22] Cappelli E., Hazra T., Hill J.W., Slupphaug G., Bogliolo M., Frosina G. // Carcinogenesis. 2001, V.22, №3, P.387-393][[23] Radicella J.P., Dherin C., Desmaze C., Fox M.S., Boiteux S. // Proc. Natl. Acad. Sci. USA. 1997, V.94, P.8010-8015][[24] Roldan-Arjona T., Wei Y.F., Carter K.C., Klungland A., Anselmino C., Wang R.P., Augustus M., Lindahl T. // Proc. Natl. Acad. Sci. USA. 1997, V.94, P.8016-8020][[25] Aburatani H., Hippo Y., Ishida T., Takashima R., Matsuba C., Kodama T., Takao M., Yasui A., Yamamoto K., Asano M. // Cancer Research 1997, V.57, P.2151-2156][[26] Rosenquist T.A., Zharkov D.O., Grollman A.P. // Proc. Natl. Acad. Sci. USA. 1997, V.94, P.7429-7434][[27] Nishioka K., Ohtsubo T., Oda H., Fujiwara T., Kang D., Sugimachi K., Nakabeppu Y. // Mol. Biol. Cell. 1999, V.10, P.1637-1652][[28] Boiteux S., Radicella J.P. // Arch. Biochem. Biophys. 2000, V.377, P.1-8][[29] Kow Y.W., Wallace S.S. // Biochemistry. 1987, V.26, №25, P.8200-8206][[30] Dodson M.L., Michaels M.L., Lloyd R.S. // J. Biol. Chem. 1994, V.269, №52, P.32709-32712][[31] Labahn J., Schärer O.D., Long A., Ezaz-Nikpay K., Verdine G.L., Ellenberger T.E. // Cell. 1996, V.86, №2, P.321-329][[32] Lee S., Radom C.T., Verdine G.L. // J. Am. Chem. Soc. 2008, V.130, №25, P.7784-7785][[33] Norman D.P.G., Bruner S.D., Verdine G.L. // J. Am. Chem. Soc. 2001, V.123, №2, P.359-360][[34] Fromme J.C., Bruner S.D., Yang W., Karplus M., Verdine G.L. // Nat. Struct. Biol. 2003, V.10, №3, P.204-211][[35] Bjørås M., Seeberg E., Luna L., Pearl L.H., Barrett T.E. // J. Mol. Biol. 2002, V.317, №2, P.171-177][[36] Bruner S.D., Norman D.P.G., Verdine G.L. // Nature 2000, V.403, №6772, P.859-866][[37] Banerjee A., Yang W., Karplus M., Verdine G.L. // Nature 2005, V.434, №7033, P.612-618][[38] Norman D.P.G., Chung S.J., Verdine G.L. // Biochemistry. 2003, V.42, №6, P.1564-1572][[39] Nash H.M., Bruner S.D., Schärer O.D., Kawate T., Addona T., Sponner E., Lane W.S., Verdine G.L. // Curr. Biol. 1996, V.6, №8, P.968-980][[40] Thayer M.M., Ahern H., Xing D., Cunningham R.P., Tainer J.A. // EMBO J. 1995, V.14, №16, P.4108-4120][[41] Guan Y., Manuel R.C., Arvai A.S., Parikh S.S., Mol C.D., Miller J.H., Lloyd S., Tainer J.A. // Nat. Struct. Biol. 1998, V.5, №12, P.1058-1064][[42] Bjørås M., Luna L., Johnsen B., Hoff E., Haug T., Rognes T., Seeberg E. // EMBO J. 1997, V.16, №20, P.6314-6322][[43] // The PyMOL Molecular Graphics System. Version 1.6.0.0 Schrödinger, LLC.][[44] Krokan H.E., Standal R., Slupphaug G. // Biochem. J. 1997, V.325, SPart 1, P.1-16][[45] Kuznetsov N.A., Koval V.V., Zharkov D.O., Nevinsky G.A., Douglas K.T., Fedorova O.S. // Nucleic Acids Res. 2005, V.33, №12, P.3919-3931][[46] Kuznetsov N.A., Koval V.V., Nevinsky G.A., Douglas K.T., Zharkov D.O., Fedorova O.S. // J. Biol. Chem. 2007, V.282, №2, P.1029-1038][[47] Radom C.T., Banerjee A., Verdine G.L. // J. Biol. Chem. 2007, V.282, №12, P.9182-9194][[48] Crenshaw C.M., Nam K., Oo K., Kutchukian P.S., Bowman B.R., Karplus M., Verdine G.L. // J. Biol. Chem. 2012, V.287, №30, P.24916-24928][[49] Bialkowski K., Cysewski P., Olinski R. // Z. Naturforsch. 1996, V.51, №1-2, P.119-122][[50] Lukina M.V., Popov A.V., Koval V.V., Vorobjev Y.N., Fedorova O.S., Zharkov D.O. // J. Biol. Chem. 2013, V.288, №40, P.28936-28947][[51] Every A.E., Russu I.M. // J. Mol. Recognit. 2013, V.26, №4, P.175-180]