Acta NaturaeActa Naturae2075-8251Acta Naturae Ltd1051210.32607/20758251-2015-7-2-115-118Research ArticleRedistribution of Free- and Cell-Surface-Bound DNA in Blood of Benign and Malignant Prostate Tumor PatientsBryzgunovaO. E.s.tamk@niboch.nsc.ruTamkovichS. N.s.tamk@niboch.nsc.ruCherepanovaA. V.s.tamk@niboch.nsc.ruYarmoshchukS. V.s.tamk@niboch.nsc.ruPermyakovaV. I.s.tamk@niboch.nsc.ruAnykeevaO. Yu.s.tamk@niboch.nsc.ruLaktionovP. P.s.tamk@niboch.nsc.ruInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesNovosibirsk State UniversityMeshalkin Novosibirsk State Research Institute of Circulation Pathology150620157211511817012020Copyright © 2015, Bryzgunova O.E., Tamkovich S.N., Cherepanova A.V., Yarmoshchuk S.V., Permyakova V.I., Anykeeva O.Y., Laktionov P.P.2015<p>A direct correlation between the concentration of cell-free and cell-surface-bound circulating DNA (cfDNA and csbDNA, respectively) was demonstrated. Based on an inverse correlation between blood plasma DNase activity and the cfDNA concentration, blood DNases are supposed to regulate the cfDNA concentration. However, no correlation was found between the DNase activity in blood plasma and the csbDNA concentration, indicating that blood DNases are not involved in csbDNA dissociation from the cell surface. The possibility of DNA redistribution between cfDNA and csbDNA indicates that the total pool of circulating DNA (cfDNA +csbDNA) should be used for a correct analysis of marker DNA concentrations and data standardization.</p>plasmacirculating DNADNase activityprostate cancerдезоксирибонуклеазная активностьплазмарак предстательной железыциркулирующие ДНК[[1] Tamkovich S.N., Laktionov P.P., Vlasov V.V. // Mol. Biol. (Mosk.). 2008, V.42, №1, P.12-24][[2] Geary R., Watanabe T., Truong L., Freier S., Lesnik E.A., Sioufi N.B., Sasmor H., Manoharan M., Levin A.A. // Pharm. Exp. Therap. 2001, V.296, №3, P.890-897][[3] Laktionov P.P., Tamkovich. S.N., Rykova E.Y., Bryzgunova O.E., Starikov A.V., Kuznetsova N.P., Vlassov V.V. // Ann. N.Y. Acad. Sci. 2004, V.1022, P.221-227][[4] Skvortsova T.E., Rykova E.Y., Tamkovich S.N., Bryzgunova O.E., Starikov A.V., Kuznetsova N.P., Vlassov V.V., Laktionov P.P. // Br. J. Cancer. 2006, V.94, №10, P.1492-1495][[5] Tamkovich S.N., Litviakov N.V., Bryzgunova O.E., Dobrodeev A.Y., Rykova E.Y., Tuzikov S.A., Zav’ialov A.A., Vlassov V.V., Cherdyntseva N.V., Laktionov P.P. // Ann. N.Y. Acad. Sci. 2008, V.1137, P.214-217][[6] Cherepanova A., Tamkovich S., Pyshnyi D., Kharkova M., Vlassov V., Laktionov P. // J. Immunol. Methods. 2007, V.325, №1-2, P.96-103][[7] Tamkovich S.N., Bryzgunova O.E., Rykova E.I., Kolesnikova E.V., Shelestiuk P.I., Laktionov P.P., Vlasov V.V. // Biomed. Khim. 2005, V.51, №3, P.321-328][[8] Beliaev N.D., Budker V.G., Gorokhova O.E., Sokolov A.V. // Mol. Biol. (Mosk.). 1988, V.22, P.1667-1672][[9] Aggarwal S., Wagner R., McAllister P., Rosenberg B. // Proc. Nat. Acad. Sci. USA. 1975, V.72, №3, P.928-932][[10] Dorsch C. // Thromb. Res. 1981, V.24, №1-2, P.119-129][[11] Morozkin E.S., Sil’nikov V.N., Rykova E.Y., Vlassov V.V., Laktionov P.P. // Bull. Exp. Biol. Med. 2009, V.147, №1, P.63-65][[12] Novitsky V.V., Ryazantseva N.V., Stepovaya Ye.A., Fyodorova T.S., Kravets Y.B., Ivanov V.V., Zhavoronok T.V., Chasovskikh N.Yu., Choudakova O.M., Butusova V.N. // Bull. Sib. Med. 2006, V.2, P.62-69]