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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Acta Naturae</journal-id><journal-title-group><journal-title xml:lang="en">Acta Naturae</journal-title><trans-title-group xml:lang="ru"><trans-title>Acta Naturae</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-8251</issn><publisher><publisher-name xml:lang="en">Acta Naturae Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10442</article-id><article-id pub-id-type="doi">10.32607/20758251-2016-8-2-75-78</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Heat Stress-Induced DNA Damage</article-title><trans-title-group xml:lang="ru"><trans-title>Повреждения ДНК при тепловом стрессе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kantidze</surname><given-names>O. L.</given-names></name><name xml:lang="ru"><surname>Кантидзе</surname><given-names>O. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kantidze@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Velichko</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Величко</surname><given-names>A. K.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kantidze@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Luzhin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Лужин</surname><given-names>A. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kantidze@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Razin</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Разин</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sergey.v.razin@usa.net</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Gene Biology, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Институт биологии гена РАН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">Московский государственный университет им. М.В. Ломоносова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2016</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="en">VOL 8, NO2 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 8, №2 (2016)</issue-title><fpage>75</fpage><lpage>78</lpage><history><date date-type="received" iso-8601-date="2020-01-17"><day>17</day><month>01</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Kantidze O.L., Velichko A.K., Luzhin A.V., Razin S.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Кантидзе O.Л., Величко A.K., Лужин A.В., Разин С.В.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Kantidze O.L., Velichko A.K., Luzhin A.V., Razin S.V.</copyright-holder><copyright-holder xml:lang="ru">Кантидзе O.Л., Величко A.K., Лужин A.В., Разин С.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://actanaturae.ru/2075-8251/article/view/10442">https://actanaturae.ru/2075-8251/article/view/10442</self-uri><abstract xml:lang="en"><p>Although the heat-stress response has been extensively studied for decades, very little is known about its effects on nucleic acids and nucleic acid-associated processes. This is due to the fact that the research has focused on the study of heat shock proteins and factors (HSPs and HSFs), their involvement in the regulation of transcription, protein homeostasis, etc. Recently, there has been some progress in the study of heat stress effects on DNA integrity. In this review, we summarize and discuss well-known and potential mechanisms of formation of various heat stress-induced DNA damage.</p></abstract><trans-abstract xml:lang="ru"><p>Хотя механизмы клеточного ответа на тепловой стресс изучаются уже несколько десятилетий, многое остается неясным. Это связано с тем, что основное внимание было сконцентрировано на изучении белков и факторов теплового шока, их участии в регуляции транскрипции, поддержании белкового гомеостаза и т.д. В последнее время достигнут определенный прогресс в исследовании влияния теплового стресса на целостность ДНК. В обзоре охарактеризованы и обсуждены известные и потенциальные механизмы образования различных повреждений ДНК при тепловом стрессе.</p></trans-abstract><kwd-group xml:lang="en"><kwd>heat shock</kwd><kwd>DNA repair</kwd><kwd>DNA damage</kwd><kwd>DNA replication</kwd><kwd>topoisomerase</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ДНК-топоизомеразы</kwd><kwd>повреждение ДНК</kwd><kwd>репарация ДНК</kwd><kwd>репликация ДНК</kwd><kwd>тепловой шок</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This work was supported by the Russian Science Foundation (grant No. 14-24-00022).</funding-statement><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке РНФ (грант № 14-24-00022).</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>[1] Richter K., Haslbeck M., Buchner J. // Molecular Cell 2010, V.40, P.253-266</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>[2] Velichko A.K., Markova E.N., Petrova N.V., Razin S.V., Kantidze O.L. // Cell Mol. 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