Email this article Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
- Authors: Matyugina E.S.1, Andreevskaya S.N.2, Smirnova T.G.2, Khandazhinskaya A.L.1
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Affiliations:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
- Issue: Vol 4, No 4 (2012)
- Pages: 73-77
- Section: Research Articles
- URL: https://actanaturae.ru/2075-8251/article/view/10619
- DOI: https://doi.org/10.32607/20758251-2012-4-4-73-77
- ID: 10619
Cite item
Abstract
9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC50 = 500 μM) and to have no significant effects on the growth of Mycobacterium tuberculosis.
About the authors
E. S. Matyugina
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Author for correspondence.
Email: khandazhinskaya@bk.ru
Russian Federation
S. N. Andreevskaya
Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
T. G. Smirnova
Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
A. L. Khandazhinskaya
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
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