The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages

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Abstract

Integrins play a critical role in the regulation of adhesion, migration, proliferation, and differentiation of cells. Because of the variety of the functions they play in the cell, they are necessary for the formation and maintenance of tissue structure integrity. The trove of data accumulated by researchers suggests that integrins participate in the morphogenesis of the epidermis and its appendages. The development of mice with tissue-specific integrin genes knockout and determination of the genetic basis for a number of skin diseases in humans showed the significance of integrins in the biology, physiology, and morphogenesis of the epidermis and hair follicles. This review discusses the data on the role of different classes of integrin receptors in the biology of epidermal cells, as well as the development of the epidermis and hair follicles.

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The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin Appendages

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About the authors

A. L. Rippa

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Author for correspondence.
Email: rippa86@yandex.ru
Russian Federation

E. A. Vorotelyak

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences; M.V. Lomonosov Moscow State University, Biological Department, Division of Cell Biology and Histology

Email: rippa86@yandex.ru
Russian Federation

A. V. Vasiliev

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Email: rippa86@yandex.ru
Russian Federation

V. V. Terskikh

N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences

Email: rippa86@yandex.ru
Russian Federation

References

  1. Hynes R.O. // Cell. 2002, V.110, №6, P.673-687
  2. Barczyk M., Carracedo S., Gullberg D. // Cell Tissue Res. 2010, V.339, №1, P.269-280
  3. Bouvard B., Brakebusch C., Gustafsson E., Aszódi A., Bengtsson T., Berna A., Fässler R. // Circ. Res. 2001, V.89, №3, P.211-223
  4. Bokel C., Brown N.H. // Dev. Cell. 2002, V.3, №3, P.311-321
  5. Stenn K.S., Paus R. // Physiol. Rev. 2001, V.81, №1, P.449-494
  6. Gray J., Dawber R. A. // Pocketbook of hair and scalp disorders: an illustrated guide. // Blackwell Science 1999, P.116
  7. Adams J.C., Watt F.M. // J. Cell Biol. 1991, V.115, №3, P.829-841
  8. Hertle M., Adams J., Watt F.M. // Development. 1991, V.112, №1, P.193-206
  9. Adams J.C., Watt F.M. // Cell. 1990, V.63, №2, P.425-435
  10. Palmer E.L., Ruegg C., Ferrando R., Pytela R., Sheppard D. // J. Cell Biol. 1993, V.123, P.1289-1297
  11. Jensen U.B., Lowell S., Watt F.M. // Development. 1999, V.126, №11, P.2409-2418
  12. Hashmi S., Marinkovich M.P. // Clin. Dermatol. 2011, V.29, №4, P.398-411
  13. Stepp M.A. // Dev. Dyn. 1999, V.214, №3, P.216-228
  14. Watt F.M. // EMBO J. 2002, V.21, №15, P.3919-3926
  15. Carroll J.M., Romero M.R., Watt F.M. // Cell. 1995, V.83, №6, P.957-968
  16. Watt F.M., Kubler M.D., Hotchin N.A., Nicholson L.J., Adams J.C. // J. Cell Sci. 1993, V.106, P.175-182
  17. Zhu A.J., Haase I., Watt F.M. // Proc. Natl. Acad. Sci. USA. 1999, V.96, №12, P.6728-6733
  18. Dowling J., Yu Q.C., Fuchs E. // J. Cell Biol. 1996, V.134, №2, P.559-572
  19. Georges-Labouesse E., Messaddeq N., Yehia G., Cadalbert L., Dierich A., LeMeur M. // Nat. Genet. 1996, V.13, №3, P.370-373
  20. Van der Neut R., Krimpenfort P., Calafat J., Niessen C.M., Sonnenberg A. // Nat. Genet. 1996, V.13, №3, P.366-369
  21. Ashton G.H., Sorelli P., Mellerio J.E., Keane F.M., Eady R.A., McGrath J.A. // Br. J. Dermatol. 2001, V.144, №2, P.408-414
  22. Germain E.C., Santos T.M., Rabinovitz I. // Mol. Biol. Cell. 2009, V.20, №1, P.56-67
  23. Kligys K.R., Wu Y., Hopkinson S.B., Kaur S., Platanias L.S., Jones J.C. // J. Biol. Chem. 2012, V.287, №22, P.17975-17984
  24. Sehgal B.U., DeBiase P.J., Matzno S., Chew T.L., Claiborne J.N., Hopkinson S.B., Russell A., Marinkovich M.P., Jones J.C. // J. Biol. Chem. 2006, V.281, №46, P.35487-35498
  25. Hintermann E., Bilban M., Sharabi A., Quaranta V. // J. Cell Biol. 2001, V.153, №3, P.465-478
  26. Russell A.J., Fincher E.F., Millman L., Smith R., Vela V., Waterman E.A., Dey C.N., Guide S., Weaver V.M., Marinkovich M.P. // J. Cell Sci. 2003, V.116, P.3543-3556
  27. Fassler R., Meyer M. // Genes Dev. 1995, V.9, P.1896-1908
  28. Stephens L.E., Sutherland A.E., Klimanskaya I.V., Andrieux A., Meneses J., Pedersen R.A., Damsky C.H. // Genes Dev. 1995, V.9, P.1883-1895
  29. Fässler R., Pfaff M., Murphy J., Noegel A.A., Johansson S., Timpl R., Albrecht R. // J. Cell Biol. 1995, V.128, №5, P.979-988
  30. Bagutti C., Wobus A.M., Fassler R., Watt F.M. // Developmental Biology 1996, V.179, №1, P.184-196
  31. Marinkovich M.P., Keene D.R., Rimberg C.S., Burgeson R.E. // Dev. Dyn. 1993, V.197, №4, P.255-267
  32. Bagutti C., Hutter C., Chiquet-Ehrismann R., Fässler R., Watt F.M. // Developmental Biology 2001, V.231, №2, P.321-333
  33. Raghavan S., Bauer C., Mundschau G., Li Q., Fuchs E. // J. Cell Biol. 2000, V.150, №5, P.1149-1160
  34. Brakebusch C., Grose R., Quondamatteo F., Ramirez A., Jorcano J.L., Pirro A., Svensson M., Herken R., Sasaki T., Timpl R. // EMBO J. 2000, V.19, №15, P.3990-4003
  35. Levy L., Broad S., Diekmann D., Evans R.D., Watt F.M. // Mol. Biol. Cell. 2000, V.11, №2, P.453-466
  36. // url www.vetmed.vt.edu./education/curriculum/ vm8054/Labs/Lab15/Lab15.htm
  37. Hotchin N.A., Gandarillas A., Watt F.M. // J. Cell Biol. 1995, V.128, №6, P.1209-1219
  38. Grose R., Hutter C., Bloch W., Thorey I., Watt F.M., Fässler R., Brakebusch C., Werner S. // Development. 2002, V.129, №9, P.2303-2315
  39. Lopez-Rovira T., Silva-Vargas V., Watt F.M. // J. Invest. Dermatol. 2005, V.125, №6, P.1215-1227
  40. Conti F.J., Rudling R.J., Robson A., Hodivala-Dilke K.M. // J. Cell Sci. 2003, V.116, P.2737-2747
  41. Kreidberg J.A., Donovan M.J., Goldstein S.L., Rennke H., Shepherd K., Jones R.C., Jaenisch R. // Development. 1996, V.122, №11, P.3537-3547
  42. DiPersio C.M., Hodivala-Dilke K.M., Jaenisch R., Kreidberg J.A., Hynes R.O. // J. Cell Biol. 1997, V.137, №3, P.729-742
  43. DiPersio C.M., van der Neut R., Georges-Labouesse E., Kreidberg J.A., Sonnenberg A., Hynes R.O. // J. Cell Sci. 2000, V.113, P.3051-3062
  44. Panteleyev A.A., Botchkareva N.V., Sundberg J.P., Christiano A.M., Paus R. // Am. J. Pathol. 1999, V.155, №1, P.159-171
  45. Oro A.E., Scott M.P. // Cell. 1998, V.95, №5, P.575-578
  46. Van Genderen C., Okamura R.M., Farinas I., Quo R.G., Parslow T.G., Bruhn L., Grosschedl R. // Genes Dev. 1994, V.8, №22, P.2691-2703
  47. St-Jacques B., Dassule H.R., Karavanova I., Botchkarev V.A., Li J., Danielian P.S., McMahon J.A., Lewis P.M., Paus R., McMahon A.P. // Curr. Biol. 1998, V.8, №19, P.1058-1068
  48. Chiang C., Swan R.Z., Grachtchouk M., Bolinger M., Litingtung Y., Robertson E.K., Cooper M.K., Gaffield W., Westphal H., Beachy P.A. // Developmental Biology 1999, V.205, №1, P.1-10
  49. Shattil S.J., Kim C., Ginsberg M.H. // Nat. Rev. Mol. Cell. Biol. 2010, V.11, №4, P.288-300
  50. Zhang X., Jiang G., Cai Y., Monkley S.J., Critchley D.R., Sheetz M.P. // Nat. Cell. Biol. 2008, V.10, №9, P.1062-1068
  51. Choi C.K., Vicente-Manzanares M., Zareno J., Whitmore L.A., Mogilner A., Horwitz A.R. // Nat. Cell Biol. 2008, V.10, №9, P.1039-1050
  52. Xu W., Baribault H., Adamson E.D. // Development. 1998, V.125, №2, P.327-337
  53. Geiger B., Spatz J.P., Bershadsky A.D. // Nat. Rev. Mol. Cell Biol. 2009, V.10, №1, P.21-33
  54. Geiger B., Yamada K.M. // Cold Spring Harb. Perspect Biol. 2011, V.3, №5, P.a005033
  55. Turner C.E. // Nat. Cell Biol. 2000. V. 2. № 12. P. E231–E236. 2000, V.2, №12, P.E231-E236
  56. Zamir E., Geiger B. // J. Cell Sci. 2001, V.114, P.3577-3579
  57. Frame M.C. // J. Cell Sci. 2004, V.117, P.989-998
  58. Mitra S.K., Hanson D.A., Schlaepfer D.D. // Nat. Rev. Mol. Cell Biol. 2005, V.6, №1, P.56-68
  59. Legate K.R., Montanez E., Kudlacek O., Fassler R. // Nat. Rev. Mol. Cell Biol. 2006, V.7, №1, P.20-31
  60. Huttenlocher A., Horwitz A.R. // Cold Spring Harb. Perspect Biol. 2011, V.3, №9, P.a005074
  61. Ridley A.J. // Bioessays. 1994, V.16, №5, P.321-327
  62. Beckerle M.C., Burridge K., DeMartino G.N., Croall D.E. // Cell. 1987, V.51, P.569-577
  63. Yu D.H., Qu C.K., Henegariu O., Lu X., Feng G.S. // J. Biol. Chem. 1998, V.273, №33, P.21125-21131
  64. Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S. // Nature 1996, V.379, P.91-96
  65. Grashoff C., Thievessen I., Lorenz K., Ussar S., Fässler R. // Curr. Opin. Cell Biol. 2004, V.16, №5, P.565-571
  66. Yamauchi K., Kurosaka A. // Arch. Dermatol. Res. 2010, V.302, №4, P.263-270
  67. Fuchs E., Merrill B.J., Jamora C., DasGupta R. // Dev. Cell. 2001, V.1, №1, P.13-25
  68. Huelsken J., Vogel R., Erdmann B., Cotsarelis G., Birchmeier W. // Cell. 2001, V.105, №4, P.533-545
  69. Zhou P., Byrne C., Jacobs J., Fuchs E. // Genes Dev. 1995, V.9, №6, P.700-713
  70. Logan C.Y., Nusse R. // Annu. Rev. Cell Dev. Biol. 2004, V.20, P.781-810
  71. Delcommenne M., Tan C., Gray V., Rue L., Woodgett J., Dedhar S. // Proc. Natl. Acad. Sci. USA. 1998, V.95, №19, P.11211-11216
  72. Novak A., Hsu S.C., Leung-Hagesteijn C., Radeva G., Papkoff J., Montesano R., Roskelley C., Grosschedl R., Dedhar S. // Proc. Natl. Acad. Sci. USA. 1998, V.95, №8, P.4374-4379
  73. Oloumi A., Syam S., Dedhar S. // Oncogene. 2006, V.25, №59, P.7747-7757
  74. Sakai T., Li S., Dicheva D., Grashoff C., Sakai K., Kostka G., Braun A., Pfeifer A., Yurchenco P.D., Fassler R. // Genes Dev. 2003, V.17, №7, P.926-940
  75. Lynch D.K., Ellis C.A., Edwards P.A., Hiles I.D. // Oncogene. 1999, V.18, №56, P.8024-8032
  76. Zervas C.G., Gregory S.L., Brown N.H. // J. Cell Biol. 2001, V.152, №5, P.1007-1018
  77. Mackinnon A.C., Qadota H., Norman K.R., Moerman D.G., Williams B.D. // Curr. Biol. 2002, V.12, №10, P.787-797
  78. Hill M.M., Feng J., Hemmings B.A. // Curr. Biol. 2002, V.12, №14, P.1251-1255
  79. Grashoff C., Aszodi A., Sakai T., Hunziker E.B., Fässler R. // EMBO Rep. 2003, V.4, №4, P.432-438
  80. Lorenz K., Grashoff C., Torka R., Sakai T., Langbein L., Bloch W., Aumailley M., Fassler R. // J. Cell Biol. 2007, V.177, №3, P.501-513
  81. Qin J., Wu C. // Curr. Opin. Cell Biol. 2012, V.24, №5, P.607-613
  82. Blanpain C., Fuchs E. // Annu. Rev. Cell Dev. Biol. 2006, V.22, P.339-373
  83. Dassule H.R., Lewis P., Bei M., Maas R., McMahon A.P. // Development. 2000, V.127, №22, P.4775-4785
  84. Manohar A., Shome S.G., Lamar J., Stirling L., Iyer V., Pumiglia K., DiPersio C.M. // J. Cell Sci. 2004, V.117, P.4043-4054
  85. Nakrieko K.A., Welch I., Dupuis H., Bryce D., Pajak A., St-Arnaud R., Dedhar S., D´Souza S.J., Dagnino L. // Mol. Biol. Cell. 2008, V.19, №4, P.1462-1473
  86. Choma D.P., Pumiglia K., DiPersio C.M. // J. Cell Sci. 2004, V.117, P.3947-3959
  87. Nakrieko K.A., Rudkouskaya A., Irvine T.S., D'Souza S.J., Dagnino L. // Mol. Biol. Cell. 2011, V.22, №14, P.2532-2540
  88. Judah D., Rudkouskaya A., Wilson R., Carter D.E., Dagnino L. // PLoS One. 2012, V.7, №5, P.e36704
  89. Watt F.M., Driskell R.R. // Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2010, V.365, P.155-163
  90. Hall P.A., Watt F.M. // Development. 1989, V.106, №4, P.619-633
  91. Scadden D.T. // Nature 2006, V.441, P.1075-1079
  92. Spradling A., Drummond-Barbosa D., Kai T. // Nature 2001, V.414, P.98-104
  93. Watt F.M., Hogan B.L. // Science. 2000, V.287, P.1427-1430
  94. Morris R.J., Liu Y., Marles L., Yang Z., Trempus C., Li S., Lin J.S., Sawicki J.A., Cotsarelis G. // Nat. Biotechnol. 2004, V.22, №4, P.411-417
  95. Tumbar T., Guasch G., Greco V., Blanpain C., Lowry W.E., Rendl M., Fuchs E. // Science. 2004, V.303, P.359-363
  96. Ordonez P., Di Girolamo N. // Stem Cells. 2012, V.30, №2, P.100-107
  97. Hayashi R., Yamoto M., Saito T., Oshima T., Okano T., Tano Y., Nishida K. // Biochem. Biophys. Res. Commun. 2008, V.367, №2, P.256-263
  98. Li A., Simmons P.J., Kaur P. // Proc. Natl. Acad. Sci. USA. 1998, V.95, №7, P.3902-3907
  99. Wagers A.J., Weissman I.L. // Stem Cells. 2006, V.24, №4, P.1087-1094
  100. Stingl J., Eirew P., Ricketson I., Shackleton M., Vaillant F., Choi D., Li H.I., Eaves C.J. // Nature 2006, V.439, P.993-997
  101. Shackleton M., Vaillant F., Simpson K.J., Stingl J., Smyth G.K., Asselin-Labat M.L., Wu L., Lindeman G.J., Visvader J.E. // Nature 2006, V.439, P.84-88
  102. Watt F.M., Fujiwara H. // Cold Spring Harb. Perspect Biol. 2011, V.3, №4, P.a005124
  103. Jones P.H., Watt F.M. // Cell. 1993, V.73, №4, P.713-724
  104. Huttenlocher A., Sandborg R.R., Horwitz A.F. // Curr. Opin. Cell Biol. 1995, V.7, №5, P.697-706
  105. Kloepper J.E., Tiede S., Brinckmann J., Reinhardt D.P., Meyer W., Faessler R., Paus R. // Exp. Dermatol. 2008, V.7, №7, P.592-609
  106. Kloepper J.E., Hendrix S., Bodo E., Tiede S., Humpries M.J., Philpott M.P., Fässler R., Paus R. // Exp. Cell Res. 2008, V.314, №3, P.498-508
  107. Sachs N., Secades P., van Hulst L., Kreft M., Song J.Y., Sonnenberg A. // Proc. Natl. Acad. Sci. USA. 2012, V.109, №52, P.21468-21473
  108. Lechler T., Fuchs E. // Nature 2005, V.437, P.275-280
  109. Moro L., Venturino M., Bozzo C., Silengo L., Altruda F., Beguinot L., Tarone G., Defilippi P. // EMBO J. 1998, V.17, №22, P.6622-6632

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