Mesenchymal Stem Cells in Tissue Growth and Repair

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Abstract


It has been established in the recent several decades that stem cells play a crucial role in tissue renewal and regeneration. Mesenchymal stem cells (MSCs) are part of the most important population of adult stem cells. These cells have hereby been identified for the very first time and subsequently isolated from bone marrow stroma. Bone marrow-derived MSCs have been believed to play the role of a source of cells for the renewal and repair of connective tissues, including bone, cartilage and adipose tissues. Cells similar to bone marrow-derived MSCs have now been identified in all postnatal tissues. Data on the distribution and function of MSCs in vivo collected using novel approaches pertaining to the identification of MSCs in situ, to their isolation from tissues, and finally to the determination of their biological properties have enabled successful revision of the role of MSCs in various organs and tissues. This review summarizes our own, as well as others’, data concerning the role of MSCs in the regulation processes of tissue repair and regeneration. In our opinion, MSCs provide the connection between the blood-vascular, immune, endocrine, and nervous systems and tissue-specific stem cells in the body.

Mesenchymal Stem Cells in Tissue Growth and Repair

N I Kalinina

Lomonosov Moscow State University

Email: n_i_kalinina@mail.ru
Department of Fundamental Medicine

V Yu Sysoeva

Lomonosov Moscow State University

Department of Fundamental Medicine

K A Rubina

Lomonosov Moscow State University

Department of Fundamental Medicine

Ye V Parfenova

Lomonosov Moscow State University

Department of Fundamental Medicine

V A Tkachuk

Lomonosov Moscow State University

Department of Fundamental Medicine

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