Targeted Therapy: A New Approach for the Treatment of Locally Advanced Oropharyngeal Cancer

Cover Page

Abstract


Presented herein is a clinical study comprising 48 patients (42 men and 6 women) of working age (40-70 years), all of whom are suffering from locally advanced oropharyngeal cancer. A modern approach is applied to treat these patients, i.e., neoadjuvant targeted therapy, taking into account the biological profile of the tumor. The use of gefitinib causes an antitumor effect in 90.5% of cases as opposed to 56.5% when no drug is applied.


L. Z. Velsher

Moscow State Medical and Dental University; Cancer Center JSC "RZD"

Email: kosmos-83@list.ru

Russian Federation

A. A. Kosmynin

Moscow State Medical and Dental University

Author for correspondence.
Email: kosmos-83@list.ru

Russian Federation

M. Yu. Byakhov

Moscow State Medical and Dental University; Cancer Center JSC "RZD"

Email: kosmos-83@list.ru

Russian Federation

T. K. Duditskaya

Moscow State Medical and Dental University; Cancer Center JSC "RZD"

Email: kosmos-83@list.ru

Russian Federation

D. N. Reshetov

Moscow State Medical and Dental University; Cancer Center JSC "RZD"

Email: kosmos-83@list.ru

Russian Federation

  1. Stewart B.W., Kleihues P.E. World Cancer Report. Lyon, France: Internat. Agency Res. on Cancer Press, 2003.
  2. Venmorven J.B. // J. Clin. Oncol. 2007. V. 25. № 16. Р 2171-2177.
  3. Chissov V.I., Starinsky V.V., Petrova G.V. Sostoyanie onkologicheskoy pomoschi naseleniyu Rossii v 2007 godu (The state of cancer care of the population of Russia in 2007). M.: FGI “MCRI of P.A.Herzen” Ministry of Health and Social Development of Russia, 2008. P. 16.
  4. Novik A.A., Kamilova T.A., Tsygan V.N. // Issues on Oncology. 2003. № 6. P 695-703.
  5. Platinsky L.V., Bryuzgin V.V., Blumenberg A.G. // Rus. Med. Jour.. 2002. V. 10. № 24. P. 1116-1118.
  6. Podvyaznikov S.O., Byakhov M.Y. // Current oncology. 2002. V. 4. № 3. P 126-130.
  7. Pignon J.P., Bourhis J. // Lancet. 2000. V. 355. P 949-955.
  8. Forastiere A.A. // Semin. Oncol. 1994. V. 21. (Suppl. 8). P. 49-52.
  9. Manzione L., Caponigro F., Massa E. // Proc. Amer. Soc. Clin. Oncol. 1999. V. 18. P. 398a.
  10. Moiseenko V.M. // Practical oncology. 2002. № 4. P. 253-261.
  11. Kopnin B.P // Practical oncology. 2002. № 4. P 229-235.
  12. Paez J.G., Janne P.A., Lee J.C. // Science. 2004. V. 304. P. 1497-1500.
  13. Rivera F., Garcia-Castano A., Vega N. // Expert. Rev. Anticancer Ther. 2009. V. 9. № 10. Р 1421-1428.
  14. Vermorken J.B., Mesia R., Rivera F. // N. Engl. J. Med. 2008. V. 359. № 11. Р 1116-1127.
  15. Grandis J.R., Melhem M.F., Gooding W.E. // J. Natl. Cancer Inst. 1998. V. 90. № 11. Р 824-828.
  16. Ono M., Kowano M. // Clin. Cancer Res. 2006. V. 12. P 7242-7251.
  17. Vernham G.A., Crowther J.A. // Clin. Otolaryngol. Allied Sci. 1994. V. 19. P. 120-124.
  18. Lynch T.J., Bell D.W., Sordella R. // N. Engl. J. Med. 2004. V. 350. P 2129-2139.
  19. Inoue A., Kobayashi K., Naemondo M. // Eur. J. Cancer 45 (Suppl. 1), 2009. (Abstract 9LBA).
  20. Lee J.S., Park K., Kim S.-W. // J. Trobac. Oncol. 4 (Suppl. 1). 2009. (Abstract PRS.4).
  21. Pao W., Miller V., Zakowski M. // Proc. Natl. Acad. Sci. USA. 2004. V. 101. P. 13306-13311.
  22. Mitsudomi T., Morita S., Yatabe Y. // Lancet Oncol. 2010. V. 11. № 2. Р 121-128.
  23. Albanell J., Rojo F., Averbuch S. // J. Clin. Oncol. 2002. V. 20. P 110-124.
  24. Korman D.B. Osnovy protivoopukholevoy khimioterapii (Basics of cancer chemotherapy). M.: Prakticheskaya meditsina, 2006. P. 282-283.
  25. Cohen J.// Br. J. Cancer. 2007. V. 96. № 3. P 408-416.

Views

Abstract - 212

PDF (English) - 125

PDF (Russian) - 86

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2012 Velsher L.Z., Kosmynin A.A., Byakhov M.Y., Duditskaya T.K., Reshetov D.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies