Regulation of Immunity via Multipotent Mesenchymal Stromal Cells

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Abstract


Immune cells responsible for inflammation development are involved in tissue damage caused by wounding and various pathologies. Control of immune cell activation could be of significant benefit for regenerative medicine and the treatment of patients with autoimmune and degenerative diseases. It is a proven fact that MCSs (multipotent mesenchymal stromal cells) are capable of suppressing immune responses via the inhibition of dendritic cell maturation and via the restraining of the T, B, and NK cell function in the course of autoimmune diseases and various forms of inflammation. MSCs can be isolated easily from almost every type of tissue or organ and subsequently expanded in vitro. These cells are self-renewable and can be differentiated into various cell types of mesenchymal lineage. The current review contains a collection and critical analysis of data regarding the molecular mechanisms responsible for cross-talk between immune cells and MSCs. Some of these mechanisms can be used for the development of new practical approaches for the treatment of autoimmune diseases.


Yu. P. Rubtsov

Lomonosov Moscow State University

Author for correspondence.
Email: yrubtsov@gmail.com

Russian Federation

Yu. G. Suzdaltseva

Institute of Experimental Cardiology

Email: yrubtsov@gmail.com

Russian Federation

K. V. Goryunov

Lomonosov Moscow State University

Email: yrubtsov@gmail.com

Russian Federation

N. I. Kalinina

Lomonosov Moscow State University

Email: yrubtsov@gmail.com

Russian Federation

V. Yu. Sysoeva

Lomonosov Moscow State University

Email: yrubtsov@gmail.com

Russian Federation

V. A. Tkachuk

Lomonosov Moscow State University

Email: yrubtsov@gmail.com

Russian Federation

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Copyright (c) 2012 Rubtsov Y.P., Suzdaltseva Y.G., Goryunov K.V., Kalinina N.I., Sysoeva V.Y., Tkachuk V.A.

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