Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity

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Abstract


9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC50 = 500 μM) and to have no significant effects on the growth of Mycobacterium tuberculosis.


E. S. Matyugina

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Author for correspondence.
Email: khandazhinskaya@bk.ru

Russian Federation

S. N. Andreevskaya

Central Tuberculosis Research Institute, Russian Academy of Medical Sciences

Email: khandazhinskaya@bk.ru

Russian Federation

T. G. Smirnova

Central Tuberculosis Research Institute, Russian Academy of Medical Sciences

Email: khandazhinskaya@bk.ru

Russian Federation

A. L. Khandazhinskaya

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Email: khandazhinskaya@bk.ru

Russian Federation

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Copyright (c) 2012 Matyugina E.S., Andreevskaya S.N., Smirnova T.G., Khandazhinskaya A.L.

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