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Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
- Authors: Matyugina E.S.1, Andreevskaya S.N.2, Smirnova T.G.2, Khandazhinskaya A.L.1
- Affiliations:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
- Issue: Vol 4, No 4 (2012)
- Pages: 73-77
- Section: Research Articles
- URL: http://actanaturae.ru/2075-8251/article/view/10619
- DOI: https://doi.org/10.32607/20758251-2012-4-4-73-77
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Abstract
9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC50 = 500 μM) and to have no significant effects on the growth of Mycobacterium tuberculosis.
E. S. Matyugina
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Author for correspondence.
Email: khandazhinskaya@bk.ru
Russian Federation
S. N. Andreevskaya
Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
T. G. Smirnova
Central Tuberculosis Research Institute, Russian Academy of Medical Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
A. L. Khandazhinskaya
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: khandazhinskaya@bk.ru
Russian Federation
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