Recombinant Influenza Vaccines

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Abstract


This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines. Such approaches as the delivery of foreign genes by DNA- and viral vector-based vaccines can preserve the native structure of antigens. Adenoviral vectors are a promising gene-delivery platform for a variety of genetic vaccines. Adenoviruses can efficiently penetrate the human organism through mucosal epithelium, thus providing long-term antigen persistence and induction of the innate immune response. This review provides an overview of the practicability of the production of new recombinant influenza cross-protective vaccines on the basis of adenoviral vectors expressing hemagglutinin genes of different influenza strains.


E. S. Sedova

Gamaleya Research Institute of Epidemiology and Microbiology

Author for correspondence.
Email: sedova-es@yandex.ru

Russian Federation

D. N. Shcherbinin

Gamaleya Research Institute of Epidemiology and Microbiology

Email: sedova-es@yandex.ru

Russian Federation

A. I. Migunov

Research Institute of Influenza

Email: sedova-es@yandex.ru

Russian Federation

Yu. A. Smirnov

Gamaleya Research Institute of Epidemiology and Microbiology; Ivanovsky Research Institute of Virology

Email: sedova-es@yandex.ru

Russian Federation

D. Yu. Logunov

Gamaleya Research Institute of Epidemiology and Microbiology

Email: sedova-es@yandex.ru

Russian Federation

M. M. Shmarov

Gamaleya Research Institute of Epidemiology and Microbiology

Email: sedova-es@yandex.ru

Russian Federation

L. M. Tsybalova

Research Institute of Influenza

Email: sedova-es@yandex.ru

Russian Federation

B. S. Naroditskiĭ

Gamaleya Research Institute of Epidemiology and Microbiology

Email: sedova-es@yandex.ru

Russian Federation

O. I. Kiselev

Research Institute of Influenza

Email: sedova-es@yandex.ru

Russian Federation

A. L. Gintsburg

Gamaleya Research Institute of Epidemiology and Microbiology

Email: sedova-es@yandex.ru

Russian Federation

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Copyright (c) 2012 Sedova E.S., Shcherbinin D.N., Migunov A.I., Smirnov I.A., Logunov D.I., Shmarov M.M., Tsybalova L.M., Naroditskiĭ B.S., Kiselev O.I., Gintsburg A.L.

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