Cobra Cytotoxins: Structural Organization and Antibacterial Activity

Cover Page

Abstract


Cardiotoxins (cytotoxins, CT) are β-structured proteins isolated from the venom of cobra. They consist of 59-61 amino acid residues, whose antiparallel chains form three ‘fingers’. In contrast to neurotoxins with an overall similar fold, CTs are amphiphilic. The amphiphilicity is caused by positively charged lysine and arginine residues flanking the tips of the loops that consist primarily of hydrophobic amino acids. A similar distribution of amino acid residues is typical for linear (without disulfide bonds) cationic cytolytic peptides from the venoms of other snakes and insects. Many of them are now considered to be lead compounds in combatting bacterial infections and cancer. In the present review, we summarize the data on the antibacterial activity of CTs and compare it to the activity of linear peptides.


P. V. Dubovskii

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: utkin@mx.ibch.ru

Russian Federation

Y. N. Utkin

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: utkin@mx.ibch.ru

Russian Federation

  1. Kini R.M., Evans H.J. // Int. J. Pept. Prot. Res. 1989, V.34, P.277-286
  2. Landon C., Meudal H., Boulanger N., Bulet P., Vovelle F. // Biopolymers. 2006, V.81, P.92-103
  3. Dubovskii P.V., Volynsky P.E., Polyansky A.A., Chupin V.V., Efremov R.G., Arseniev A.S. // Biochemistry. 2006, V.45, P.10759-10767
  4. Bhattacharjya S., Domadia P.N., Bhunia A., Malladi S., David S.A. // Biochemistry. 2007, V.46, P.5864-5874
  5. Dubovskii P.V., Volynsky P.E., Polyansky A.A., Karpunin D.V., Chupin V.V., Efremov R.G., Arseniev A.S. // Biochemistry. 2008, V.47, P.3525-3533
  6. Abbassi F., Lequin O., Piesse C., Goasdoue N., Foulon T., Nicolas P., Ladram A. // J. Biol. Chem. 2010, V.285, P.16880-16892
  7. Legrand B., Laurencin M., Sarkis J., Duval E., Moret L., Hubert J.F., Cohen M., Vie V., Zatyiny-Gaudin C., Henry J., Baudi-Floc’h M., Bondon A. // Biochim. Biophys. Acta. 2011, V.1808, P.106-116
  8. Wang G., Li X., Wang Z. // Nucleic Acids Res. 2009, V.37, №933, P.937
  9. Bauer F., Schweimer K., Kluver E., Conejo-Garcia J.R., Forssmann W.G., Rosch P., Adermann K., Sticht H. // Protein Sci. 2001, V.10, P.2470-2479
  10. Powers J.P.S., Rozek A., Hancock R.E.W. // Biochim. Biophys. Acta. 2004, V.1698, P.239-250
  11. Sayyed-Ahmad A., Kaznessis Y.N. // PloS One. 2009, V.4, №3, P.e4799
  12. Konshina A.G., Dubovskii P.V., Efremov R.G. // Curr. Protein Pept. Sci. 2012, V.13, P.570-584
  13. Yount N.Y., Kupferwasser D., Spisni A., Dutz S.M., Ramjan Z.H., Sharma S., Waring A.J., Yeaman M.R. // Proc. Natl. Acad. Sci. USA. 2009, V.106, P.14972-14977
  14. Dubovskii P.V., Vassilevski A.A., Samsonova O.V., Egorova N.S., Kozlov S.A., Feofanov A.V., Arseniev A.S., Grishin E.V. // FEBS J. 2011, V.278, P.4382-4393
  15. Mader J.S., Hoskin D.W. // Expert Opin. Investig. Drugs. 2006, V.15, P.933-946
  16. Hoskin D.W., Ramamoorthy A. // Biochim. Biophys. Acta. 2008, V.1778, P.357-375
  17. Schweizer F. // Eur. J. Pharmacol. 2009, V.625, P.190-194
  18. Riedl S., Zweytick D., Lohner K. // Chem. Phys. Lipids. 2011, V.164, P.766-781
  19. Fazio M.A., Jouvensal L., Vovelle F., Bulet P., Miranda M.T., Daffre S., Miranda A. // Biopolymers. 2007, V.88, P.386-400
  20. Haney E.F., Hunter H.N., Matsuzaki K., Vogel H.J. // Biochim. Biophys. Acta. 2009, V.1788, P.1639-1655
  21. Feliu L., Oliveras G., Cirac A.D., Besalu E., Roses C., Colomer R., Bardaji E., Pianas M., Puig T. // Peptides. 2010, V.31, P.2017-2026
  22. Fadnes B., Uhlin-Hansen L., Lindin I., Rekdal O. // BMC Cancer. 2011, V.11, P.116
  23. Dubovskii P.V., Konshina A.G., Efremov R.G. // Curr. Med. Chem. 2014, V.21, P.270-287
  24. Nguyen L.T., Chau J.K., Perry N.A., de Boer L., Zaat S.A., Vogel H.J. // PloS One. 2010, V.5, P.e12684
  25. Verardi R., Traaseth N.J., Shi L., Porcelli F., Monfregola L., De Luca S., Amodeo P., Veglia G., Scaloni A. // Biochim. Biophys. Acta. 2011, V.1808, P.34-40
  26. Dufton M.J., Hider R.C. // Pharmacol. Ther. 1988, V.36, P.1-40
  27. Kumar T.K., Jayaraman G., Lee C.S., Arunkumar A.I., Sivaraman T., Samuel D., Yu C. // J. Biomol. Struct. Dyn. 1997, V.15, P.431-463
  28. Kini R.M., Doley R. // Toxicon. 2010, V.56, P.855-867
  29. Chien K.Y., Chiang C.M., Hseu Y.C., Vyas A.A., Rule G.S., Wu W. // J. Biol. Chem. 1994, V.269, P.14473-14483
  30. Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Konshina A.G., Utkin Y.N., Efremov R.G., Arseniev A.S. // Biochem. J. 2005, V.387, P.807-815
  31. Dubinnyi M.A., Lesovoy D.M., Dubovskii P.V., Chupin V.V., Arseniev A.S. // Solid State Nucl. Magn. Reson. 2006, V.29, P.305-311
  32. Feofanov A.V., Sharonov G.V., Dubinnyi M.A., Astapova M.V., Kudelina I.A., Dubovskii P.V., Rodionov D.I., Utkin Y.N., Arseniev A.S. // Biochemistry (Mosc.). 2004, V.69, P.1148-1157
  33. Feofanov A.V., Sharonov G.V., Astapova M.V., Rodionov D.I., Utkin Y.N., Arseniev A.S. // Biochem. J. 2005, V.390, P.11-18
  34. Wang C.H., Wu W.G. // FEBS Lett. 2005, V.579, P.3169-3174
  35. Wu M., Ming W., Tang Y., Zhou S., Kong T., Dong W. // Am. J. Chin. Med. 2013, V.41, P.643-663
  36. Wu P.L., Chiu C.R., Huang W.N., Wu W.G. // Biochim. Biophys. Acta. 2012, V.1818, P.1378-1385
  37. Epand R.M., Rotem S., Mor A., Berno B., Epand R.F. // J. Am. Chem. Soc. 2008, V.130, P.14346-14352
  38. Dubovskii P.V., Dementieva D.V., Bocharov E.V., Utkin Y.N., Arseniev A.S. // J. Mol. Biol. 2001, V.305, P.137-149
  39. Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Utkin Y.N., Arseniev A.S. // Eur. J. Biochem. 2003, V.270, P.2038-2046
  40. Tjong S.C., Chen T.S., Huang W.N., Wu W.G. // Biochemistry. 2007, V.46, P.9941-9952
  41. Galat A., Gross G., Drevet P., Sato A., Menez A. // FEBS J. 2008, V.275, P.3207-3225
  42. Chen T.S., Chung F.Y., Tjong S.C., Goh K.S., Huang W.N., Chien K.Y., Wu P.L., Lin H.C., Chen C.J., Wu W.G. // Biochemistry. 2005, V.44, P.7414-7426
  43. Dementieva D.V., Bocharov E.V., Arseniev A.S. // Eur. J. Biochem. 1999, V.263, P.152-162
  44. Dauplais M., Neumann J.M., Pinkasfeld S., Menez A., Roumestand C. // Eur. J. Biochem. 1995, V.230, P.213-220
  45. Vyas A.A., Pan J.J., Patel H.V., Vyas K.A., Chiang C.M., Sheu Y.C., Hwang J.K., Wu W.G. // J. Biol. Chem. 1997, V.272, P.9661-9670
  46. Vyas K.A., Patel H.V., Vyas A.A., Wu W.G. // Biochemistry. 1998, V.37, P.4527-4534
  47. Pal S.K., Gomes A., Dasgupta S.C., Gomes A. // Indian J. Exp. Biol. 2002, V.40, P.1353-1358
  48. de Lima D.C., Abreu A.P., de Freitas C.C., Santos D.O., Borges R.O., Dos Santos T.C., Cabral M.R., Rodrigues C.R., Castro H.C. // Evid. Based Complement. Alternat. Med. 2005, V.2, P.39-47
  49. Koh D.C., Armugam A., Jeyaseelan K. // Cell. Mol. Life Sci. 2006, V.63, P.3030-3041
  50. Samy P.R., Gopalakrishnakone P., Thwin M.M., Chow T.K., Bow H., Yap E.H., Thong T.W. // J. Appl. Microbiol. 2007, V.102, P.650-659
  51. Gomes A., Bhattacharjee P., Mishra R., Biswas A.K., Dasgupta S.C., Giri B. // Indian J. Exp. Biol. 2010, V.48, P.93-103
  52. Kapoor V.K. // Indian J. Exp. Biol. 2010, V.48, P.228-237
  53. King G.F. // Expert Opin. Biol. Ther. 2011, V.11, P.1469-1484
  54. Lazarev V.N., Govorun V.M. // Appl. Biochem. Microbiol. 2010, V.46, P.803-814
  55. Koh C.Y., Kini R.M. // Toxicon. 2012, V.59, №4, P.497-506
  56. Talan D.A., Citron D.M., Overturf G.D., Singer B., Froman P., Goldstein E.J. // J. Infect. Dis. 1991, V.164, P.195-198
  57. Thomas R.G., Pough F.H. // Toxicon. 1979, V.17, P.221-228
  58. Glaser H.S.R. // Copeia. 1948, P.245-247
  59. Stiles B.G., Sexton F.W., Weinstein S.A. // Toxicon. 1991, V.29, P.1129-1141
  60. Okubo B.M., Silva O.N., Migliolo L., Gomes D.G., Porto W.F., Batista C.L., Ramos C.S., Holanda H.H., Dias S.C., Franco O.L., Moreno S.E. // PLoS One. 2012, V.7, P.e33639
  61. Rima M., Accary C., Haddad K., Sadek R., Hraoui-Bloquet S., Desfontis J.C., Fajloun Z. // Infect. Disord. Drug. Targets. 2013, V.13, P.337-343
  62. Stocker J.F., Traynor J.R. // J. Appl. Microbiol. 1986, V.61, P.383-388
  63. Samy P.R., Pachiappan A., Gopalakrishnakone P., Thwin M.M., Hian Y.E., Chow V.T., Bow H., Weng J.T. // BMC Infect. Dis. 2006, V.6, P.100
  64. Lee M.L., Tan I.O., N.H. I.O., Fung S.Y., Sekaran S.D. // Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 2011, V.153, P.237-242
  65. Samy P.R., Gopalakrishnakone P., Ho B., Chow V.T. // Biochimie. 2008, V.90, P.1372-1388
  66. Aloof-Hirsch S., de Vries A., Berger A. // Biochim. Biophys. Acta. 1968, V.154, P.53-60
  67. Mollmann U., Gutsche W., Maltz L., Ovadia M. // Toxicon. 1997, V.35, P.487-487
  68. Raghuraman H., Chattopadhyay A. // Biosci. Rep. 2007, V.27, P.189-223
  69. Kozlov S.A., Vassilevski A.A., Feofanov A.V., Surovoy A.Y., Karpunin D.V., Grishin E.V. // J. Biol. Chem. 2006, V.281, P.20983-20992
  70. Vassilevski A.A., Kozlov S.A., Zhmak M.N., Kudelina I.A., Dubovskii P.V., Shatursky O.Y., Arseniev A.S., Grishin E.V. // Rus. J. Bioorgan. Chem. 2007, V.33, P.376-382
  71. Torres A.M., Wong H.Y., Desai M., Moochhala S., Kuchel P.W., Kini R.M. // J. Biol. Chem. 2003, V.278, P.40097-40104
  72. Nair D.G., Fry B.G., Alewood P., Kumar P.P., Kini R.M. // Biochem. J. 2007, V.402, P.93-104
  73. Wang Y., Hong J., Liu X., Yang H., Liu R., Wu J., Wang A., Lin D., Lai R. // PLoS One. 2008, V.3, P.e3217
  74. Chen L.W., Kao P.H., Fu Y.S., Lin S.R., Chang L.S. // Toxicon. 2011, V.58, №1, P.46-53
  75. Bhunia A., Domadia P.N., Torres J., Hallock K.J., Ramamoorthy A., Bhattacharjya S. // J. Biol. Chem. 2010, V.285, P.3883-3895
  76. Piers K.L., Brown M.H., Hancock R.E. // Antimicrob. Agents Chemother. 1994, V.38, P.2311-2316
  77. Arcidiacono S., Soares J.W., Meehan A.M., Marek P., Kirby R. // J. Pept. Sci. 2009, V.15, P.398-403
  78. Chen L.W., Kao P.H., Fu Y.S., Hu W.P., Chang L.S. // Peptides. 2011, V.32, №8, P.1755-1763
  79. Kao P.H., Lin S.R., Hu W.P., Chang L.S. // Toxicon. 2012, V.60, P.367-377
  80. Marchot P., Bougis P.E., Ceard B., van Rietschoten J., Rochat H. // Biochem. Biophys. Res. Commun. 1988, V.153, P.642-647
  81. Smith C.A., Hinman C.L. // J. Biochem. Mol. Toxicol. 2004, V.18, P.204-220
  82. Smith C.A., Hinman C.L. // Arch. Biochem. Biophys. 2004, V.432, P.88-101
  83. Shenkarev Z.O., Balandin S.V., Trunov K.I., Paramonov A.S., Sukhanov S.V., Barsukov L.I., Arseniev A.S., Ovchinnikova T.V. // Biochemistry. 2011, V.50, P.6255-6265
  84. Kaplan N., Morpurgo N., Linial M. // J. Mol. Biol. 2007, V.369, P.553-566
  85. Dubovskii P.V., Vorontsova O.V., Utkin Y.N., Arseniev A.S., Efremov R.G., Feofanov A.V. // Mendeleev Communications. 2015. in press.

Views

Abstract - 240

PDF (English) - 71

PDF (Russian) - 80

Cited-By


PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2014 Dubovskii P.V., Utkin Y.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies